Background: Adjuvant acupuncture for the symptomatic treatment of migraine reduces the frequency of headaches and may be at least similarly effective to treatment with prophylactic drugs. Methods: This article describes an open-label randomized controlled clinical trial with two groups: the intervention group (n=42) and the waiting-list control group (n=44). This study occurred at the Czech-Chinese Center for Traditional Chinese Medicine at the University Hospital Hradec Kralove between October 2015 and April 2017. Results: After 12 weeks of acupuncture, the number of migraine days was reduced by 5.5 and 2.0 days in the acupuncture and the waiting-list control groups, respectively, with a statistically significant inter-group difference of 2.0 migraine days (95% CI: -4 to -1). A significantly greater reduction in the number of migraine days per 4 weeks was reached at the end of the 6-month follow-up period in the acupuncture vs. control groups (Δ -4.0; 95% CI: -6 to -2). A statistically significant difference was observed in the number of responders to treatment (response defined as at least a 50% reduction in average monthly migraine day frequency) in the acupuncture vs waiting-list control groups (50% vs 27%; p<0.05) at the end of the intervention. A significantly greater percentage of responders to treatment was noted in the intervention vs control groups at the 6-month follow-up (81% vs 36%; p<0.001). Conclusion: Acupuncture can reduce symptoms and medication use, both short term and long term, as an adjuvant treatment in migraine prophylaxis in Czech patients.
- Publikační typ
- časopisecké články MeSH
The aim of this study was to explore the changes in the adipokines leptin and adiponectin in obese patients with type 1 diabetes mellitus (T1DM) who underwent seven days of fasting and 21 days of low-calorie diet (LCD). The plasma leptin and adiponectin concentrations were measured in 14 obese patients with T1DM at baseline, immediately after 7 days of fasting, and after 21 days of LCD. 13 non-obese patients with T1DM were studied only after an overnight fasting. Bioimpedance technique was used for determination of body composition. Obese T1DM patients lost 6.0 kg (6.0; 6.8) (median, 25 %; 75 %) and decreased their fat tissue after fasting and LCD. Plasma leptin in obese T1DM was significantly higher than in non-obese T1DM patients: 9.10 (5.06; 25.89) vs. 1.71 (1.12; 7.08) microg . l(-1) and transiently decreased immediately after fasting: 3.45 microg . l(-1) (1.47; 7.00), (P<0.05). Adiponectin/leptin ratio in obese T1DM was significantly lower than in non-obese T1DM patients: 0.67 (0.57; 1.49) vs. 3.50 (2.46; 6.30) . 10(3) and transiently increased immediately after fasting: 2.22 (1.26; 3.24) . 10(3), (P<0.05). We conclude that obese patients with T1DM are characterized by hyperleptinemia that is reduced by prolonged fasting, but only slightly affected by low calorie diet.
- MeSH
- adiponektin krev MeSH
- diabetes mellitus 1. typu krev komplikace dietoterapie MeSH
- dospělí MeSH
- glukosa metabolismus MeSH
- glykemický clamp MeSH
- hmotnostní úbytek * MeSH
- kalorická restrikce MeSH
- kyseliny mastné neesterifikované krev MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- obezita krev etiologie MeSH
- omezení příjmu potravy MeSH
- složení těla MeSH
- tuková tkáň patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Prediabetes je důležitá klinická jednotka s definovanou diagnostikou, patogenezí a klinickým obrazem. Prediabetes predikuje rozvoj diabetes mellitus 2. typu, znamená současně výrazné kardiovaskulární riziko a mírně zvyšuje i riziko onkologického onemocnění. Prediabetes by měl být proto léčen, základem je úprava režimu spojená s edukací a vhodná je medikace metforminem.
Prediabetes is important clinical unit with defined diagnostics, pathogenesis and clinical picture. Prediabetes predicts onset of type 2 diabetes mellitus and it also means a significant increase in overall cardiovascular risk as well as a moderate increase in oncologic disease risk. Prediabetes thus warrants treatment; the therapy consists primarily of regime changes along with patient education, and the addition of pharmacotherapy using metformin is suitable.
- MeSH
- cvičení MeSH
- diabetes mellitus 2. typu prevence a kontrola MeSH
- dietoterapie metody MeSH
- glukózový toleranční test MeSH
- krevní glukóza analýza MeSH
- lidé MeSH
- metformin * aplikace a dávkování terapeutické užití MeSH
- prediabetes * diagnóza farmakoterapie terapie MeSH
- zdravé chování MeSH
- Check Tag
- lidé MeSH
