PURPOSE: The objective of our study was to identify changes in the coagulation and serum concentration of soluble P-selectin (sP-sel) after i.v. bolus of 0.75 mg/kg enoxaparin in a group of 33 patients during PCI. METHODS AND RESULTS: As compared to baseline, i.v. enoxaparin increased anti -Xa activity and FIIa inhibition together with APTT and thrombin time tests within 20 min, that persisted for 60 min. At 6 h, the results of all tests had returned to baseline. In contrast, the level of prothrombin fragments (F1 + 2) decreased persistingly for a period of 6 h (baseline 1.19 ± 0.42 nmol/l, after 20 min 1.03 ± 0.46 nmol/l, after 60 min 1.06 ± 0.43 nmol/l, after 6 h 0.95 ± 0.40 nmol/l, p < 0.001 vs. baseline for all values). In addition, i.v. enoxaparin decreased serum sP-sel level (baseline 111.80 ± 37.05 ng/ml, after 20 min 87.80 ± 33.17 ng/ml, after 60 min 86.45 ± 29.15 ng/ml, after 6 h 92.24 ± 31.34 ng/ml, p < 0.001 vs. baseline value for all). sP-sel level mildly correlated with both F Xa inhibition (r = -0.275, p < 0.05) and F1 + 2 level (r = 0.274, p < 0.05). CONCLUSION: Intravenous enoxaparin induced target F Xa inhibition (>0.6 IU/ml) for 60 min in 82% of study patients. During the 6 h of monitoring, a decrease of thrombin generation (F1 + 2) and sP-selectin levels were observed.
- MeSH
- antikoagulancia farmakologie MeSH
- balónková koronární angioplastika metody MeSH
- časové faktory MeSH
- enoxaparin farmakologie MeSH
- faktor Xa MeSH
- inhibitory faktoru Xa MeSH
- injekce intravenózní MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen terapie MeSH
- P-selektin účinky léků metabolismus MeSH
- parciální tromboplastinový čas MeSH
- protrombin antagonisté a inhibitory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- thrombin účinky léků metabolismus MeSH
- trombinový čas MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- dospělí MeSH
- hospitalizace MeSH
- kardiochirurgické výkony metody MeSH
- koronární angiografie MeSH
- koronární restenóza prevence a kontrola MeSH
- lidé MeSH
- mortalita MeSH
- náklady na zdravotní péči MeSH
- stenty MeSH
- systémy cílené aplikace léků MeSH
- výsledek terapie MeSH
- znovupřijetí pacienta MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- MeSH
- elektrokardiografie využití MeSH
- infarkt myokardu diagnóza MeSH
- lidé MeSH
- retrospektivní studie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kongresy MeSH
- MeSH
- arterioskleróza farmakoterapie ultrasonografie MeSH
- statiny aplikace a dávkování farmakologie MeSH
- výsledek terapie MeSH
- Publikační typ
- kongresy MeSH
Objective: We were interested in the prevalence of smoking amongst teen-age students, its possible causes, and their understanding of its associated health risks. Methods: We constructed a questionnaire that was responded to by a total of 419 students from 5 high schools in Prague, Czech Republic. Students were classified as non-smokers, mild (1-10 cigarettes daily), moderate (11-20 cigarettes daily), and severe smokers (>20 cigarettes daily). The survey also contained questions about passive smoking, motivation for smoking, the understanding of its associated health risks, alcohol consumption, and drugs. Results: We found that amongst 16-20 years old high school students there are 37.5% smokers (38.0% men, and 37.0% women). The majority are mild smokers (82.3%), 15.8% moderate smokers and 1.9% heavy smokers. 29.0% of non-smokers reported passive smoking; i.e. that 65.7% of students are exposed to harmful effect of tobacco smoke. The average onset of smoking is at 14 years of age. The youngest smoker started smoking at the age of 5 years. Parents of 52.0% of students smoke (69.4% of smokers and 41.6% of non-smokers). Most of students know about the risk of lung cancer and cardiovascular diseases (86-99%). Conclusions: The prevalence of active and passive smoking among high school students is high. Parents smoking is significantly more frequent in teen-age smokers than in non-smokers. We consider the „teen-age“ population together with their parents to be the key target for a successful antismoking campaign.
- MeSH
- dospělí MeSH
- kouření MeSH
- lidé MeSH
- odvykání kouření MeSH
- programy národního zdraví MeSH
- průzkumy a dotazníky MeSH
- studenti MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
