PURPOSE: The aim of the study was to determine the accuracy of [(18)F]fluorodeoxyglucose (FDG) PET/CT in the search for the primary and the presence of a malignancy. The prognostic value of FDG-PET/CT information was tested. METHODS: A total of 190 patients were retrospectively analysed: 82 with histologically proven metastases (HPM) and 108 with clinical suspicion of the presence of a malignancy (CSM). The sensitivity and specificity were determined. Overall survival was calculated to evaluate the prognostic value of the FDG-PET/CT findings. RESULTS: In the search for the primary, the sensitivity and specificity were 62.0% and 81.9%, respectively. In the search for the presence of a malignancy, the sensitivity and specificity were 93.6% and 85.7%, respectively. Between the HPM and CSM groups, no significant difference in sensitivity and specificity was found either in the search for the primary or in the search for the presence of a malignancy. No significant difference in the sensitivity and specificity was found between 78 patients who were investigated by contrast-enhanced FDG-PET/CT and the remaining patients. A significantly shorter overall survival was found among patients with positive FDG-PET/CT findings compared with patients with negative findings (p = 0.00001); no significant difference in survival was found between the HPM and the CSM group (p = 0.770). CONCLUSION: FDG-PET/CT imaging is very helpful in the search for the presence of a malignancy in patients with carcinoma of unknown primary syndrome. FDG-PET/CT is less accurate in identifying exactly the site of a primary. Discovery of a hypermetabolic lesion was associated with the worst survival rate.
- MeSH
- Adult MeSH
- Fluorodeoxyglucose F18 diagnostic use MeSH
- Risk Assessment methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasms, Unknown Primary mortality MeSH
- Positron-Emission Tomography statistics & numerical data MeSH
- Prevalence MeSH
- Prognosis MeSH
- Radiopharmaceuticals diagnostic use MeSH
- Reproducibility of Results MeSH
- Risk Factors MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Subtraction Technique MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Geographicals
- Czech Republic MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
111 l. : il., tab., grafy ; 32 cm
Předmětem projektu je definování úlohy pozitronové emisní tomografie (PET) s pomocí fluorodeoxyglukózy (18FDG) při diferenciální diagnostice rekurence či perzistence mozkového nádoru od nekrózy nebo fibrózy indukované terapií. Smyslem projektu je upřesnit terapeutický postup u pacientů s reziduální mozkovou lézí po terapii. Projekt má charakter prospektivní slepé studie plánované na 3 roky. Předpokládá se Pet vyšetření cca 130 pacientů v průběhu léčby.; The subject of thr project is the definition of the role of positron emission tomography (PET) with the aid of fluorodeoxyglucose (18FDG) for differential diagnosis of recurrent or persistent brain tumor opposed to therapy induced necrosis or fibrosis. The aim of the project resides in more precise therapeutic procedure in patients with residual cerebral lesion after a therapy. The project has the character of a prospective blind study envisaged for three years.Repeated PET examinations of about hundredpatients prior to the treatment and after the same and the comparison of findings including quantification.
- MeSH
- Diagnosis, Differential MeSH
- Brain Neoplasms MeSH
- Necrosis MeSH
- Recurrence MeSH
- Tomography, Emission-Computed MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- radiologie, nukleární medicína a zobrazovací metody
- neurologie
- NML Publication type
- závěrečné zprávy o řešení grantu IGA MZ ČR
