- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Klíčová slova
- virtual microscopy,
- MeSH
- histologie * výchova MeSH
- lidé MeSH
- počítačem řízená výuka MeSH
- tréninková simulace * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- hodnotící studie MeSH
- práce podpořená grantem MeSH
We introduced a new method of teaching practical histology using virtual slides (VS) at the Department of Histology and Embryology in Olomouc. In the database of e-practical sessions there are sets of virtual slides for each topic taught, and several supporting documents available to students that help them to orient easily in the subject of the practical session. We have also introduced practical examination of histology slides with electronic tests on personal computers (PC). We have prepared our own specific set of evaluation questions and allowed students to evaluate this new method of practical sessions. The results of these anonymous questionnaires are of a great importance to our teaching staff, as they represent an important feedback for further improvement of teaching practical histology. Comparing student´s responses in three subsequent academic years, we have found no changes in their highly positive evaluation of the use of PC for observation of virtual slides. Increase in positive responses were observed in answers to questions concerning the use of supporting documents attached to the database of virtual slides (from 50% to 68%) and active preparation of students prior to practical sessions (from 3% to 15%). Students also admitted that they increasingly benefited from the in-course electronic testing (from 86% to 93%) that motivated students to more systematic studies during two semesters of the histology course. They unequivocally preferred electronic forms of examinations over oral ones. On the other hand, students agreed that they were not able to express their theoretical knowledge properly in oral discussions or exams.
- Klíčová slova
- PC testing,
- MeSH
- histologie výchova MeSH
- lidé MeSH
- počítačem řízená výuka * klasifikace metody MeSH
- průzkumy a dotazníky MeSH
- studenti lékařství MeSH
- studium lékařství metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- MeSH
- histologie výchova MeSH
- počítačem řízená výuka metody trendy MeSH
- počítačové metodologie MeSH
- programovaná výuka jako téma * MeSH
- studium lékařství metody MeSH
- výuka - hodnocení * metody statistika a číselné údaje MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- audiovizuální pomůcky * využití MeSH
- histologie * výchova MeSH
- mikroskopie MeSH
- počítačem řízená výuka metody trendy MeSH
- počítačové metodologie MeSH
- programovaná výuka jako téma * MeSH
- studium lékařství metody MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
One of the most important features of embryonic cells is their resistence to xenobiotics, which provides a natural protection for embryos against these potentially harmful molecules. In this way, embryo cells resemble cancer cells and thus understanding the basis of this phenomenon may contribute to overcoming the multi-drug-resistance (MDR) of some tumours. Peroxisome proliferator-activated receptors (PPARs) are steroid nuclear receptors that regulate diverse biological processes such as lipid and carbohydrate metabolism, development, differentiation, apoptosis, neoplastic transformation, inflammation and regeneration of tissues. Recently it has been found that they may also regulate the expression of some MDR proteins. In this article we summarise the main known relationships between some MDR pumps and three isoforms of PPAR receptors (PPAR-alpha, PPAR-beta/delta, PPAR-gamma). We hypothesize that regulation of MDR proteins by PPAR ligands in embryos could lead to the improvement of cancer treatment.
- MeSH
- embryo savčí metabolismus MeSH
- embryonální vývoj fyziologie MeSH
- lidé MeSH
- mnohočetná léková rezistence MeSH
- P-glykoproteiny metabolismus MeSH
- receptory aktivované proliferátory peroxizomů fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
