- MeSH
- fyziologická adaptace MeSH
- lidé MeSH
- novorozenec * fyziologie MeSH
- poporodní období MeSH
- Check Tag
- lidé MeSH
- novorozenec * fyziologie MeSH
- Publikační typ
- přehledy MeSH
Gastropathy is one of the most common diseases of the human gastrointestinal tract. Apart from its consequences in the stomach, it is also manifested in other parts of the digestive tract, particularly in the duodenum. The aim of this pilot study was to verify on animal model the empirically observed alleviation of gastropathy symptoms in patients who underwent a drinking treatment of Vincentka natural mineral water during their spa treatment. Sixteen male Wistar rats were included in the study. The animals were randomly divided into two groups: experimental group (E; n=8) and control group (C; n=8). The experimental protocol consisted of three phases: (1) handling phase (7 days); (2) mineral water (E)/tap water (C) administration (7 days); (3) acute gastritis induction (1 day). Twenty-four hours after the induction of acute gastritis, the animals were sacrificed. The collected tissues (stomach and duodenum) and blood were examined by standard histological microscopy, and by immunohistochemical and biochemical methods. Histopathological analysis revealed significantly reduced damage to the gastric mucosa in the experimental group. Significantly different values of blood plasma antioxidant capacity, oxidative stress parameters and blood plasma biochemical parameters were also found. Based on these results, we conclude that the mineral water Vincentka has a positive impact on development and symptoms of acute gastric ulcers.
Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized - however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
- MeSH
- analýza pulzové vlny * MeSH
- arteriae carotides MeSH
- arteriální tlak MeSH
- hormonální antikoncepce * škodlivé účinky MeSH
- krevní tlak fyziologie MeSH
- lidé MeSH
- mladiství MeSH
- pilotní projekty MeSH
- tuhost cévní stěny * fyziologie MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- Publikační typ
- časopisecké články MeSH
Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68+/-10 years, BP 158/90+/-19/9 mm Hg) and healthy controls (5 m/6 f, age 23+/-2 years, BP 117/76+/-9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.
- MeSH
- analýza pulzové vlny metody MeSH
- diabetes mellitus 2. typu metabolismus patologie MeSH
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- nemoci cév diagnóza metabolismus patologie MeSH
- postura těla fyziologie MeSH
- rychlost toku krve fyziologie MeSH
- senioři MeSH
- srdeční frekvence fyziologie MeSH
- studie případů a kontrol MeSH
- tuhost cévní stěny MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Nutritional status, its assessment and its influence on numerous diseases is currently still being discussed. The aim of this study was to determine the current state of nutrition by various research methods in school children. Also, to verify the accuracy of body mass index (BMI) determination in school environment and to compare the nutritional status in two different types of school. We used a quantitative questionnaire method in 64 children from schools in the South Moravian Region. We have verified the weight and height measurement in the same group by sophisticated instruments. We have determined the basic parameters of the cardiovascular system (non-invasive continuously blood pressure recording; mutual spectral analysis for estimation of baroreflex sensitivity; applanation tonometry and cardiac polygraphy for arterial stiffness evaluation). The indicative questionnaire method encountered a problem with the weight of almost 40 % of the population approached - both obesity (14.3 %) and malnutrition (25.2 %). Cardiovascular parameters were in physiological range for the given age categories. We found increased values in BMI, % of body fat and heart rate in children from countryside type of school, respectively. We concluded that obesity/malnutrition are both common phenomena in the children population in the Czech Republic.
- MeSH
- cévní index srdce-kotník MeSH
- krevní tlak * MeSH
- lidé MeSH
- městské obyvatelstvo statistika a číselné údaje MeSH
- mladiství MeSH
- nutriční stav * MeSH
- obezita epidemiologie patofyziologie MeSH
- pilotní projekty MeSH
- podvýživa epidemiologie patofyziologie MeSH
- tuhost cévní stěny * MeSH
- venkovské obyvatelstvo statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- akutní nemoc MeSH
- antiarytmika terapeutické užití MeSH
- bradykardie farmakoterapie terapie MeSH
- infarkt myokardu farmakoterapie terapie MeSH
- kardiostimulace umělá metody MeSH
- katetrizace metody MeSH
- lidé MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- srdeční arytmie * farmakoterapie terapie MeSH
- tachykardie farmakoterapie terapie MeSH
- těhotné ženy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- akutní nemoc MeSH
- antiarytmika terapeutické užití MeSH
- bradykardie farmakoterapie terapie MeSH
- infarkt myokardu farmakoterapie terapie MeSH
- kardiostimulace umělá metody MeSH
- katetrizace metody MeSH
- lidé MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- srdeční arytmie * farmakoterapie terapie MeSH
- tachykardie farmakoterapie terapie MeSH
- těhotné ženy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Anthracyclines represent one of the important classes of anti-cancer drugs; however, their major disadvantage is their profound cardiovascular toxicity. This study aimed to evaluate influence of anthracyclines on cardiovascular stiffness parameters estimated from pulse wave (PW). PW was measured in 59 cancer survivors treated with anthracyclines in childhood and in 248 healthy age-matched controls. Both patients and controls were divided into three age groups (13 - 15, 16 - 18 and 19 - 24 years). Central PW augmentation index (C-AI75) and augmentation pressure (C-AP75), both normalized to heart rate 75 bpm, were calculated as parameters of arterial wall stiffness. Central Buckberg sub-endocardial viability ratio (SEVR) was calculated as a parameter of diastolic function. Patients and controls were compared in each age group. C-AI75 and C-AP75 were significantly increased in patients in age groups 16 - 18 and 19 - 24 years. SEVR was decreased in patients in the oldest age group. Our results suggest that although toxic influence of anthracyclines to arterial wall and heart are developing during childhood and puberty, they can be detected rather in the adulthood. These changes are yet subclinical; however, their presence indicates potentially increased cardiovascular risk in childhood cancer survivors treated with anthracyclines during childhood.
- MeSH
- analýza pulzové vlny metody MeSH
- antibiotika antitumorózní škodlivé účinky MeSH
- antracykliny škodlivé účinky MeSH
- krevní tlak účinky léků fyziologie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nemoci cév chemicky indukované diagnóza patofyziologie MeSH
- přežívající onkologičtí pacienti * MeSH
- srdeční frekvence účinky léků fyziologie MeSH
- tuhost cévní stěny fyziologie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
