BACKGROUND: Monitoring effectiveness of pertussis vaccines is necessary to adapt vaccination strategies. PERTINENT, Pertussis in Infants European Network, is an active sentinel surveillance system implemented in 35 hospitals across six EU/EEA countries. We aim to measure pertussis vaccines effectiveness (VE) by dose against hospitalisation in infants aged <1 year. METHODS: From December 2015 to December 2019, participating hospitals recruited all infants with pertussis-like symptoms. Cases were vaccine-eligible infants testing positive for Bordetella pertussis by PCR or culture; controls were those testing negative to all Bordetella spp. For each vaccine dose, we defined an infant as vaccinated if she/he received the corresponding dose >14 days before symptoms. Unvaccinated were those who did not receive any dose. We calculated (one-stage model) pooled VE as 100*(1-odds ratio of vaccination) adjusted for country, onset date (in 3-month categories) and age-group (when sample allowed it). RESULTS: Of 1,393 infants eligible for vaccination, we included 259 cases and 746 controls. Median age was 16 weeks for cases and 19 weeks for controls (p < 0.001). Median birth weight and gestational age were 3,235 g and week 39 for cases, 3,113 g and week 39 for controls. Among cases, 119 (46 %) were vaccinated: 74 with one dose, 37 two doses, 8 three doses. Among controls, 469 (63 %) were vaccinated: 233 with one dose, 206 two doses, 30 three doses. Adjusted VE after at least one dose was 59 % (95 %CI: 36-73). Adjusted VE was 48 % (95 %CI: 5-71) for dose one (416 eligible infants) and 76 % (95 %CI: 43-90) for dose two (258 eligible infants). Only 42 infants were eligible for the third dose. CONCLUSIONS: Our results suggest moderate one-dose and two-dose VE in infants. Larger sample size would allow more precise estimates for dose one, two and three.
V roce 2022 bylo v České republice v rámci surveillance hlášeno celkem pět případů onemocnění difterií. Difterie (neboli záškrt) nebyla v České republice hlášena od roku 1995. Článek je stručným souhrnem stávajícísituace v ČR a v zemích EU/EHP.
In 2022 as a result ofsurveillance, a total of five cases of diphtheria were reported in the Czech Republic. Diphtheria had not been reported in the Czech Republic since 1995. This article is a brief summary of the current situation in the Czech Republic and EU/EEA countries.
- MeSH
- Corynebacterium patogenita MeSH
- difterie * diagnóza epidemiologie přenos prevence a kontrola MeSH
- epidemiologické monitorování MeSH
- hlášení nemocí MeSH
- lidé MeSH
- morbidita MeSH
- mortalita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
V roce 2022 bylo v České republice v rámci surveillance dávivého kašle hlášeno celkem 96 případů onemocnění pertusí, nemocnost činila 0,9/100000 obyvatel, a celkem 87 případů onemocnění parapertusí, nemocnost 0,8/100000 obyvatel. Lze konstatovat, že epidemiologická situace této nemoci v roce 2022 byla klidná.
In 2022, a total of 96 cases of pertussis were reported in the Czech Republic under whooping cough surveillance, with an incidence of 0.9/100 000 population, and a total of 87 cases of parapertussis, with an incidence of 0.8/100 000 population. It can be concluded that the epidemiological situation of this disease in 2022 was calm.
- MeSH
- hlášení nemocí statistika a číselné údaje MeSH
- lidé MeSH
- pertuse * diagnóza epidemiologie prevence a kontrola MeSH
- pertusová vakcína MeSH
- surveillance populace MeSH
- věkové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- tabulky MeSH
- Geografické názvy
- Česká republika MeSH
