BACKGROUND: Adipose lesions of nerve primarily include intra- and extraneural lipomas and lipomatosis of nerve (LN). This paper will summarize the advances that have been made in the past decade, particularly related to LN and nerve territory overgrowth that have improved our understanding of the natural history, genetic background, diagnosis, imaging features, and clinical management. METHODS AND MATERIALS: Articles about adipose lesions of nerve were reviewed from 2011, when the last comprehensive review on this topic was published. Papers reporting advances on natural history, genetic background, diagnosis, imaging features, and clinical management were screened using PubMed and Google Scholar databases and then analyzed. Case reports and small case series were included only if they reported model examples of discussed pathologies, as these types of articles were summarized in recent systematic reviews on intraneural lipomas and LN. All eligible papers were assessed by the authors, who are subject matter experts. RESULTS: The first screen revealed 404 articles. After careful evaluation, a total of 53 articles were analyzed which includes advances in diagnosis (especially imaging), classification of the lesions, the role of somatic mutations in PIK3CA in LN, and treatment approaches for all adipose lesions of the peripheral nerve. CONCLUSION: Many advances have been made in the understanding of adipose lesions of nerve in the past decade. These pathologic entities are more readily recognized as a spectrum of lesions that share common phenotypic features.
- MeSH
- fosfatidylinositol-3-kinasy třídy I MeSH
- hamartom patologie MeSH
- lidé MeSH
- lipom patologie MeSH
- lipomatóza genetika patologie MeSH
- nádory periferního nervového systému patologie MeSH
- nemoci periferního nervového systému genetika patologie MeSH
- tuková tkáň patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
INTRODUCTION: Neuroblastoma ranks third among pediatric malignancies. CASE REPORT: The case of a 3-year-old child is presented, who suddenly had frequent, unproductive, emetic cough; fever; and weight loss. Lung X-ray showed an opacity situated in the posterior superior mediastinum. Thoracic ultrasound revealed a slightly inhomogeneous, hypoechoic mass located in the posterior superior mediastinum. Computed tomography evidenced a tumor mass with homogeneous appearance in the costo-vertebral groove. Histological examination confirmed the diagnosis of ganglioneuroblastoma. CONCLUSION: Although history and clinical examination provided few elements, diagnosis was made based on imaging and histopathological examination.
- MeSH
- ganglioneuroblastom diagnóza patologie chirurgie MeSH
- lidé MeSH
- nádory periferního nervového systému diagnóza patologie chirurgie MeSH
- předškolní dítě MeSH
- sympatická ganglia patologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- hýždě inervace MeSH
- ischialgie diagnóza MeSH
- lidé MeSH
- nádory periferního nervového systému diagnóza patologie MeSH
- nemoci sedacího nervu diagnóza patologie MeSH
- nervus ischiadicus patologie MeSH
- neurilemom diagnóza patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Tumors of the hand comprise a vast array of lesions involving skin, soft tissue and bone. The majority of tumors in the hand are benign. Malignant tumors, although rare, do occur and frequently have unique characteristics in this specific anatomic location. Careful staging, histological diagnosis and treatment are essential to optimize clinical outcome. However, straightforward most of the time, hand tumor management does have pitfalls; caution is advised, as a missed or delayed diagnosis or an improperly executed biopsy may have devastating consequences. This article reviews the clinical spectrum of the most common benign and malignant bone and soft tissue tumors of the hand and discusses the clinicopathological findings, imaging features and current concepts in treatment for these tumors.
- MeSH
- cystická ganglia terapie MeSH
- fibrom chirurgie MeSH
- lidé MeSH
- lipom chirurgie MeSH
- nádory kostí patologie terapie MeSH
- nádory kůže patologie terapie MeSH
- nádory měkkých tkání patologie terapie MeSH
- nádory periferního nervového systému patologie terapie MeSH
- obrovskobuněčný nádor šlachové pochvy chirurgie MeSH
- ruka * MeSH
- sarkom patologie terapie MeSH
- staging nádorů MeSH
- vaskulární nádory diagnostické zobrazování patologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- lidé MeSH
- nádory kůže patologie MeSH
- nádory periferního nervového systému patologie MeSH
- plexus brachialis patologie MeSH
- senioři nad 80 let MeSH
- spinocelulární karcinom patologie sekundární MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
BACKGROUND: Fibrolipomatous hamartoma of the nerve is a rare benign infiltrating condition of peripheral nerves with prominent cutaneous findings that has not being well described in the dermatologic and dermatopathologic literature. OBJECTIVE: We sought to evaluate the clinical and histopathological features of this rare condition. METHODS: We reviewed the clinicopathologic features of 13 cases to delineate their clinical presentation and histopathologic spectrum. RESULTS: All patients presented with unilateral lesions on the thenar areas, fingers, or both. In 7 cases the lesions presented congenitally and in 6 cases the lesions presented sporadically. Histologically, we found 2 patterns that have only been rarely mentioned before including cases with intraneural perineurioma-like features and cases with marked nerve hyperplasia. LIMITATIONS: Only 13 cases were included in our study. CONCLUSIONS: This condition is an uncommon entity. The diagnosis of this disorder can be highly suspected on its macroscopic features. Predilection of the median nerve and the frequent association with macrodactyly are characteristic clinical findings.
- MeSH
- dítě MeSH
- dospělí MeSH
- hamartom komplikace diagnóza patologie MeSH
- hodnocení rizik MeSH
- imunohistochemie MeSH
- jehlová biopsie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipom komplikace diagnóza patologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory periferního nervového systému komplikace diagnóza patologie MeSH
- prognóza MeSH
- prsty ruky abnormality patologie MeSH
- vrozené deformity končetin etiologie patologie MeSH
- vzácné nemoci MeSH
- vzorkové studie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- dospělí MeSH
- hematom MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody využití MeSH
- meningitida MeSH
- nádory periferního nervového systému diagnóza genetika chirurgie klasifikace patologie terapie MeSH
- neurilemom diagnóza genetika chirurgie klasifikace patologie terapie MeSH
- neurofibromatóza 2 patofyziologie MeSH
- paréza MeSH
- pooperační komplikace MeSH
- prognóza MeSH
- radiochirurgie metody přístrojové vybavení MeSH
- vestibulární schwannom klasifikace MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
A 16-year-old boy presented with an intraneural perineurioma arising from a small nerve in the buccal mucosa. Histologically, the tumour comprised a tortuous proliferation of spindle cells arranged like an onion bulb. To our knowledge this is the third example of an intraneural perineurioma that did not present in a major nerve.
- MeSH
- lidé MeSH
- nádory periferního nervového systému diagnóza chirurgie patologie MeSH
- neurilemom diagnóza chirurgie terapie MeSH
- neurofibrom komplikace MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Outline: The paper presents the results of 33 microsurgical removal of 33 tumours of brachial plexus and of peripheral nerves in extremities performed on 31 patients during the period of 11 years, from 1990 to 2001. Patient group and methods: The patient group included 26 patients treated for removal of 28 tumours of peripheral nerves in extremities and 5 patients treated for removal of 5 tumours of brachial plexus. Three of these brachial plexus tumours showed intraspinal spread. 32 tumours of neural sheath included 20 schwannomas and 12 neurofibromas. 6 of these 12 neurofibromas were observed in 4 patients suffering from Reklinghausen disease (VRD). One patient had a tumour of non-neural elements – lipoma. We did not encounter any malign tumours of neural sheaths or other neural sheath-derived tumours (benign or metastatic malign ones) that would compress or invade the nerves or plexus. The results were evaluated according to Donner classification of motor and sensory functions. Results: Motor functions improved or remained unchanged in 18 (90%) patients with schwannoma. 5 patients (83.3%) with pain in the distribution of the affected nerve reported complete or partial improvement of the symptoms. Regarding neurofibroma patients, 3 exhibited either an improvement or unchanged motor functions, and all of them reported partial or complete retreat of pain symptoms. 4 patients with VRD were subjected to the removal of 6 tumours of peripheral nerves in extremities; all of them exhibited improved or stabilised motor functions and partial or complete retreat of pain symptoms. The outcome of treatments was generally better in smaller tumours of neural sheaths with more distal localisation.
