- MeSH
- dítě MeSH
- energetický metabolismus fyziologie genetika imunologie MeSH
- energetický příjem fyziologie genetika imunologie MeSH
- fyziologie výživy dětí fyziologie genetika MeSH
- fyziologie výživy kojenců fyziologie genetika MeSH
- genomový imprinting * fyziologie genetika imunologie MeSH
- homeostáza * fyziologie genetika imunologie MeSH
- kojenec MeSH
- lidé MeSH
- mateřské mléko metabolismus MeSH
- mikrobiota fyziologie genetika imunologie MeSH
- mladiství MeSH
- nadváha dietoterapie prevence a kontrola MeSH
- obezita dětí a dospívajících * diagnóza dietoterapie epidemiologie MeSH
- předškolní dítě MeSH
- primární prevence metody trendy výchova MeSH
- statistika jako téma MeSH
- vývoj plodu fyziologie genetika imunologie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: Omentin is an adipokine expressed predominantly in visceral adipose tissue, with adipose tissue stromal cells being the main source. Very little is known about the relationship between the genetic variability of the omentin gene and pathophysiology of obesity, although omentin is believed to play an important role in visceral obesity development. The aim of the study was to investigate two common polymorphisms in the omentin gene (rs2274908 and rs2274907) and dietary composition and anthropometric parameters of obesity in the Central European population. MATERIAL AND METHODS: A total of 495 subjects were included into the study, they were further dividend into the non-obese, obese, and morbidly obese cohorts. Dietary habits were established using the 7-day food records and selected anthropometric parameters were measured. RESULTS: There were significant differences in genotype distributions of rs2274907 between the obese and morbidly obese cohorts (P = 0.01). In the multivariate modelling, the rs2274907 polymorphism expressed independent prediction role for the daily energy intake, independently on the age and gender (P = 0.03); the TT genotype associated with the lowest (7877 ± 2780 J/day) and the AA genotype with the highest (8764 ± 2467 J/day) average energy intake. The rs2274907 also significantly associated with the daily consumption of fat and proteins. CONCLUSION: This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.
- MeSH
- cytokiny krev genetika MeSH
- dieta MeSH
- dietní proteiny aplikace a dávkování MeSH
- dietní tuky aplikace a dávkování MeSH
- dospělí MeSH
- energetický příjem genetika MeSH
- genotyp MeSH
- GPI-vázané proteiny krev genetika MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus * MeSH
- lektiny krev genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- obezita genetika MeSH
- polymorfismus délky restrikčních fragmentů genetika MeSH
- senioři MeSH
- stravovací zvyklosti MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
The FTO gene variants are the most important genetic determinants of body weight and obesity known so far, but the mechanism of their effect remains unclear. We have analyzed FTO rs17817449 variant (G>T in first intron) in 6024 adults aged 45-69 years to assess the potential mediating role of diet and physical activity. Diet was assessed by a 140-item food frequency questionnaire. Physical activity was measured by hours spent during a typical week by sport, walking and other activities outside of work requiring heavy and medium physical activity. Basal metabolic rate was calculated according Schofield formula. The FTO variant was significantly associated with body mass index (means in GG, GT and TT carriers were 28.7, 28.2 and 27.8 kg/m(2), p<0.001) and basal metabolic rate (BMR) (means in GG, GT and TT were 1603, 1588 and 1576 kcal per day, respectively, p<0.008) but it was not associated with physical activity, total energy intake or with energy intakes from fat, carbohydrates, proteins or alcohol. Results were essentially similar in men and women and the adjustment for physical activity or dietary energy intake did not reduce the effect of the FTO polymorphism. Means of BMR per kg of body weight was lowest in GG carriers (20.09, 20.21 for GT and 20.30 for TT, p<0.006) and this effect was more pronounced in females. These results suggest that the effect of the FTO rs17817449 variant on BMI in Caucasian adults is not mediated by energy intake or physical activity, but some effect on BMR per kg of body weight is possible.
- MeSH
- bazální metabolismus genetika MeSH
- běloši genetika MeSH
- cvičení MeSH
- energetický příjem genetika MeSH
- financování organizované MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- proteiny genetika MeSH
- složení těla genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Neuromedin beta (NMB) is a member of the bombesin-like peptide family expressed in brain, gastrointestinal tract, pancreas, adrenals and adipose tissue. The aim of our study was to compare the frequency of P73T polymorphism in overweight and obese patients (37 men: age 50.6+/-11.7 years, BMI 41.1+/-7.8 kg/m(2); 255 women: age 49.0+/-11.9 years, BMI 37.9+/-6.8 kg/m(2)) with that of healthy normal weight subjects (51 men: age 28.2+/-7.1 years, BMI 22.3+/-2.0 kg/m(2); 104 women: age 29.1+/-9.1 years, BMI 21.5+/-1.9 kg/m(2)) and to investigate the polymorphism's influence on anthropometric, nutritional and psychobehavioral parameters in overweight/obese patients both at the baseline examination and at a control visit carried out 2.5 years later, regardless of the patient s compliance with the weight reduction program. No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects. Male T allele non-carriers compared to T allele carriers had higher energy (p=0.009), protein (p=0.018) and fat (p=0.002) intakes and hunger score (p=0.015) at the beginning of treatment. Male T allele non-carriers had a more favorable response to weight management at the follow-up, as they exhibited a significant reduction in waist circumference, energy intake and depression score as well as a significant increase in dietary restraint. No significant differences between carriers and non-carriers were demonstrated in women at the baseline examination. Both female T allele carriers and non-carriers demonstrated similar significant changes in nutritional parameters and in restraint score at the follow-up. Nevertheless, only female non-carriers showed a significant decrease in the hunger score.
- MeSH
- adherence pacienta MeSH
- dospělí MeSH
- energetický příjem genetika MeSH
- genotyp MeSH
- hlad fyziologie MeSH
- hmotnostní úbytek genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- nadváha genetika MeSH
- následné studie MeSH
- neurokinin B analogy a deriváty genetika MeSH
- obezita genetika MeSH
- pilotní projekty MeSH
- polymorfismus genetický * MeSH
- sexuální faktory MeSH
- stravovací zvyklosti fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
