Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 μm, CI 8.90, to 211.4 μm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.

• MeSH
• arteria centralis retinae * diagnostické zobrazování   MeSH
• fluoresceinová angiografie MeSH
• klid na lůžku škodlivé účinky   MeSH
• lidé MeSH
• retinální cévy diagnostické zobrazování   MeSH
• vena centralis retinae * diagnostické zobrazování   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Objective: Conduct and evaluate system-level evidence-based practice intervention for deep vein thrombosis (DVT) prevention. Design: One group post-intervention survey evaluation. Setting: A mother-baby unit in a tertiary hospital. Interventions/me­asurement: Educating nurses, implementing an evidence-based deep vein thrombosis (DVT) prevention guideline in the mother-baby unit, and recommending policy changes. Outcomes were measured using Omaha System Knowledge, Behavior, and Status scales (1 = lowest – 5 = highest) for nurse DVT knowledge and practice behavior, and implementation of policy recommendations. Results: Twenty nurses (80%) completed the evaluation survey. The nurses reported that their knowledge increased significantly (3.70 vs. 4.40; p < 0.001). Behavior was variable in DVT guideline adherence. After training, most nurses (65%) usually or always assessed women for DVT risk, and some (35%) usually or always applied compression boots for DVT. The majority of nurses (70%) reported that women refused compression boots. Nurses who did not usually or always assess patients were statistically less likely to apply boots (p = 0.022). The nurses who reported discomfort with the procedure (30%) were statistically less likely to apply stockings (p = 0.028). Policy implementation to support evidence-based DVT prevention increased significantly (p = 0.008). Conclusion: Comprehensive evidence-based interventions resulted in practice and system change to prevent DVT. Nurses‘ knowledge about DVT prevention increased and some nurses consistently assessed for DVT and applied compression boots. The facility supported the implementation of the guideline and implemented unit/facility policy changes.

• MeSH
• klid na lůžku * ošetřování   škodlivé účinky   MeSH
• komplikace těhotenství MeSH
• lidé MeSH
• ošetřovatelství založené na důkazech MeSH
• role ošetřovatelky MeSH
• těhotenství MeSH
• zdravotní výchova metody   MeSH
• žilní trombóza prevence a kontrola   MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Spojené státy americké MeSH

• MeSH
• časové faktory MeSH
• dospělí MeSH
• klid na lůžku škodlivé účinky   MeSH
• kosmický let MeSH
• kosti a kostní tkáň fyziologie   metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• pohlavní steroidní hormony analýza   krev   metabolismus   moč   MeSH
• stav beztíže MeSH
• testosteron analýza   krev   metabolismus   moč   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• souhrny MeSH

• MeSH
• klid na lůžku ošetřování   škodlivé účinky   MeSH
• lidé MeSH
• omezení pohyblivosti MeSH
• ošetřovatelská péče MeSH
• pacienti hospitalizovaní MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• senioři MeSH

• MeSH
• imobilizace MeSH
• klid na lůžku škodlivé účinky   MeSH
• senioři MeSH
• syndrom prevence a kontrola   MeSH
• Check Tag
• senioři MeSH

• MeSH
• fyziologie krevního oběhu a dýchání MeSH
• klid na lůžku škodlivé účinky   MeSH
• kosti a kostní tkáň fyziologie   MeSH
• metabolismus MeSH
• svaly fyziologie   MeSH
• zdraví MeSH
• Publikační typ
• kongresy MeSH
• sborníky MeSH

• Konspekt
• Fyziologie člověka a srovnávací fyziologie
• NLK Obory
• fyziologie

• MeSH
• klid na lůžku škodlivé účinky   MeSH

• MeSH
• chybná zdravotní péče MeSH
• klid na lůžku škodlivé účinky   MeSH
• mladiství MeSH
• poranění páteře terapie   MeSH
• sporty MeSH
• Check Tag
• mladiství MeSH
• Publikační typ
• kazuistiky MeSH