"NR8538" Dotaz Zobrazit nápovědu
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
Přeruš. str. : il., tab. ; 30 cm
Modern treatment of fractures of long bones with devastation soft tissues consists in covering the defect with a muscular or musculocutaneous flap on a determined vascular bundle after the fixation of the bone fragment. Recently it has been found out that an exact surgical treatment in combination with tissue transfer may be used also for the treatment of subsequently developed infectious complication in the region fracture covered with low-quality scarred tissue. In the recent years the Departments ofprincipal investigators have treated annually about 10 patients with a subsequent infectious complication after the devastating injury of soft tissues associated with the fracture of the tibia. The planned research should evaluate whether the method usedmay be considered sophisticated enough to be proposed as the method of choice in late infectious complications arising from tibial fractures associated with devastating injury of soft tissues.
Moderní léčbou zlomenin dlouhých kostí s devastací měkkých tkání je krytí defektu po stabilizaci zlomeniny. Lze využít muskulární nebo muskulokutánní lalok transpozicí laloku na definované cévní stopce. V poslední době se ukazuje, že exaktní chirurgickousanací skeletu ve spojení s tkáňovým přenosem lze léčit i následně vzniklé infekční komplikace v terénu hojící se či zhojené zlomeniny kryté neplnohodnotnou jizevnatou tkání. V posledních letech bylo v součinnosti pracovišť navrhovatelů grantu ošetřenokolem 10 pacientů ročně s následnou infekční komplikací po předchozím devastujícím poranění měkkých tkání spojených se zlomeninou bérce. Plánovaná studie by umožnila vyhodnotit zda použitou techniku lze považovat za natolik sofistikovanou, aby byla navržena jako metoda volby u pozdních infekčních komplikací po zlomeninách bérce s předchozí devastací měkkých tkání.
- MeSH
- bérec chirurgie MeSH
- chirurgické laloky MeSH
- fraktury kostí terapie MeSH
- infekce chirurgické rány MeSH
- management nemoci MeSH
- mikrochirurgie metody MeSH
- pooperační komplikace MeSH
- rány a poranění chirurgie komplikace MeSH
- Konspekt
- Ortopedie. Chirurgie. Oftalmologie
- NLK Obory
- traumatologie
- ortopedie
- infekční lékařství
- NLK Publikační typ
- závěrečné zprávy o řešení grantu IGA MZ ČR
- MeSH
- anastomóza chirurgická metody MeSH
- angiografie metody MeSH
- arteriae tibiales abnormality radiografie ultrasonografie MeSH
- chirurgické laloky krevní zásobení využití MeSH
- dolní končetina krevní zásobení zranění MeSH
- financování organizované MeSH
- fraktury kostí komplikace MeSH
- hojení fraktur MeSH
- lidé středního věku MeSH
- lidé MeSH
- osteomyelitida diagnóza etiologie chirurgie MeSH
- píštěle etiologie chirurgie mikrobiologie MeSH
- počítačová rentgenová tomografie využití MeSH
- výkony cévní chirurgie metody MeSH
- zákroky plastické chirurgie metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
The goal of this work is to compare therapeutic results of two groups of patients with an infected fracture or chronic osteomyelitis of the lower leg and ankle joint treated by the method of radical debridement followed by free flap transfer or muscle transposition. PatientS: In the period between 1 January 2002 and 30 September 2007 the authors used this method in the treatment of 52 patients (10 females and 42 males) with the average age of 44 years (ages ranged from 10 to 67). The observed group of patients was divided into retrospective and prospective subgroups. METHODS: The difference between the retrospective and prospective parts of the study was how radical the debridement and necrectomy of the soft tissues was. A comparison of therapeutic results in both subgroups was made by evaluation of the amounts of postoperative complications, number of follow-up surgeries and the actual weight-bearing ability of the treated extremity. RESULTS: The difference in the number of postsurgical complications (7 versus 2) was not significant (p=0.123), and neither was the difference in the number of follow-up surgeries (20 versus 17, p=0.706). The difference in the number of patients with fully weightbearing extremities (21 versus 22) was also not significant (p=0.670). CONCLUSION: The authors feel that analysis of complications showed somewhat better results in the prospective part of the study, despite the lack of statistical proof. Therefore the authors regard the method of extensive debridement with the following coverage of the soft tissue defect by muscle flap as suitable for the treatment of infected fractures in the area of the lower leg and ankle joint and the treatment of osteomyelitis of the tibia.
- MeSH
- chirurgické laloky MeSH
- chronická nemoc MeSH
- debridement MeSH
- dítě MeSH
- dospělí MeSH
- financování organizované MeSH
- fraktury tibie chirurgie komplikace MeSH
- hlezenní kloub MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- osteomyelitida chirurgie MeSH
- prospektivní studie MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- antibakteriální látky terapeutické užití MeSH
- chirurgické laloky využití MeSH
- debridement metody využití MeSH
- financování organizované MeSH
- lidé MeSH
- ortopedické výkony metody ošetřování využití MeSH
- osteomyelitida farmakoterapie terapie MeSH
- plastická chirurgie metody využití MeSH
- tibie chirurgie metabolismus účinky záření MeSH
- Check Tag
- lidé MeSH
CÍL: Autoři hodnotí výsledky mezioborové léčby 16 pacientů s posttraumatickou osteomyelitidou tibie. METODA: Pacienti byli léčeni metodou rozsáhlého debridement skeletu i měkkých tkání a následného krytí defektu svalovým lalokem. VÝSLEDKY A ZÁVĚR: Sanace infektu i plná nosnost končetiny při průměrném sledování 48 měsíců opravňuje autory považovat tento postup za metodu vhodnou při léčení chronické osteomyelitidy tibie.
AIM: The autors evaluate the results of interdisciplinary treatment of 16 patients with posttraumatic tibial osteomyelitis. METHOD: Patients were treated with the extensive debridement of bone and soft tissue and subsequent muscle flap covering of the defect. RESULTS AND CONCLUSION: The cure of infection and full limb weight-bearing with the average follow-up of 48 months support this technique for treatment of chronic tibial ostemyelitis.
- MeSH
- chirurgické laloky využití MeSH
- debridement využití MeSH
- lidé MeSH
- ortopedické výkony metody MeSH
- osteomyelitida etiologie mikrobiologie terapie MeSH
- tibie chirurgie zranění MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
Long-term or recurrent osteomyelitis results in the deterioration of soft tissue quality at the site of an infectious process. An insufficient perfusion of the scar tissue contributes to difficult treatment of osteomyelitis. A local transpositional or free muscle flap used to replace the vulnerable scar tissue will enhance perfusion of the affected bone and will help to control osteomyelitis. The authors present the case of a patient who had been treated by bone transport for a 14-cm-long segmental defect of the tibia after post-traumatic osteomyelitis. Recurrent osteomyelitis was found nine years after the primary surgery. The whole tibial cavity was opened leaving a 12-mm-wide trepanation opening, and debridement of all necrotic and inflammatory tissue including dystrophic skin was performed. The Orr technique was used for further treatment. There was no relapse and granulation tissue samples repeatedly gave negative culture results. Therefore, at the second stage, the soft tissue defect was covered with a free latissimus dorsi muscle flap. Anastomoses to the recipient vessels were technically difficult to carry out in the tissue greatly affected by previous chronic inflammation. Ten days after the surgery the patient was allowed to stand and walk, full weight-bearing was allowed at 2 months post-operatively when the flap was completely integrated. At 6-year follow-up the extremity was fully weight-bearing, with no recurrence of infection, and the patient was satisfied with the outcome. The authors regard this interdisciplinary management (extensive bone and soft tissue debridement, free muscle flap transfer) as a method indicated for the treatment of recurrent tibial osteomyelitis.
- MeSH
- chirurgické laloky MeSH
- debridement MeSH
- dospělí MeSH
- financování organizované MeSH
- fraktury tibie komplikace MeSH
- Ilizarovova technika MeSH
- lidé MeSH
- ortopedické výkony MeSH
- osteomyelitida etiologie chirurgie MeSH
- recidiva MeSH
- tibie chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Postupná partikularizace medicíny, které jsme byli svědky ve druhé polovině 20. století, vedla k detailnějšímu rozvoji jednotlivých podoborů. Spojení terapeutických možností vzniklých enormním rozvojem těchto podoborů přineslo novou dimenzi při léčení dříve nezvládnutelných stavů. Spolupráce plastického chirurga a traumatologa je nejtěsnější při péči o pacienty se závažnými končetinovými traumaty. Jedná se zejména o amputace končetin bez devastace skeletu a měkkých tkání, u kterých je možné se pokusit o replantaci a rozsáhlá poranění měkkých tkání a skeletu vyžadujících po ošetření skeletu náhradu chybějícího měkkotkáňového krytu. Novým aspektem této spolupráce je společná péče o infikované zlomeniny a osteomyelitidy dlouhých kostí, u kterých po provedení primárního a rozsáhlého debridement skeletu a měkkých tkání následuje krytí defektu muskulárním nebo muskulokutánním lalokem umožňující novou perfuzi a zvládnutí infektu.
Gradual particularization of medicine, as witnessed during the second half of the 20th century, resulted in a detailed development of individual subspecializations. Association of therapeutic options resulting from enormous development of these subspecialization brought a new dimension to the treatment of formerly unmanageable conditions. The closest cooperation between a plastic surgeon and a traumatologist is required in the management of patients with serious extremitiy injuries. The conditions include, in particular, amputations of extremities without skeletal and soft tissue devastation, where replantation may be considered, and extensive soft tissue and skeletal injuries, requiring replacement of the missing soft tissue cover following the treatment of the skeletal parts. A new aspect of the cooperation includes common care for infected long bone fractures and osteomyelitides, where primary and extensive skeletal and soft tissue debridement is followed by covering the defect with a muscular or a musculocutaneous flap, facilitating reperfusion and infection management.
PURPOSE OF THE STUDY The aim of the study was to evaluate the results of treatment in patients with infected fractures or chronic osteomyelitis in the tibial and ankle regions by radical debridement of skeletal and soft tissues and coverage of the defect, using free flap transfer or muscle flap transposition. MATERIAL Between January 1, 2002 and December 31, 2004, 26 patients were treated by this method; 13 had infected tibial or ankle fractures and 13 showed osteomyelitis of the tibia. All patients, in the case of failure, would have been indicated for below-knee amputation. The group comprised six women and 20 men at an average age of 46 years (range, 10 to 67 years). METHODS In this retrospective study, the following data were recorded: type of injury (multiple trauma, combined trauma, single trauma), fracture type according to the AO classification, grade of injury in open fractures by the Gustillo and Anderson classification, number of previous operations in patients with infected fractures, microbiological findings in all patients before defect coverage with a flap, interval between the injury and flap coverage, number of post-operative complications, number of subsequent operations, period of relief for the treated limb, actual weight-bearing of the limb, patient's satisfaction with the therapy. RESULTS Since one patient died of heart attack during follow-up, 25 patients (5 women and 20 men) were included in the final evaluation. The average follow-up was 27 months (range, 15 to 49 months). The healing of infection and union of bone were recorded in 21 patients (84 %). Healing with pseudoarthrosis development occurred in three patients (12 %). One patient (4 %) had to undergo leg amputation due to persistent secretion. The duration of treatment before coverage of the defect was on average 10 weeks (range, 4 weeks to 6 months) in the patients with infected fractures, and 9 years (range, 2 to 20 years) in the patients with osteomyelitis. Post-operative complications were recorded in seven patients (27 %). Impaired vascularization of the flap in the early post-operative period was found in two patients (8 %). In two patients (8 %) residual infected tissue under the flap resulted in purulent secretion. In three patients (12 %), at the time of evaluation, the lower extremity could not bear weight due to non-union of fractured bone. DISCUSSION The use of free or transposition muscle is regarded as the optimal method for the treatment of extensive defects of soft tissues in limb traumatology The advantages include: good quality coverage of the defect; ability of vascularized flap tissue to transport antibiotic to the defect area; long-term improved perfusion in the fracture region is important for fracture healing. CONCLUSIONS The treatment of infected tibial and malleolar fractures by debridement and subsequent coverage of soft tissue defects, using muscle flap transfer, permits elimination of infection in most of the patients, but often requires subsequent surgery in order to provide biological stimulation for healing of defective fractures. Treatment of osteomyelitis of the tibia by this method is demanding, but has a good prospect of healing in a period shorter than is necessary for treatment without muscle flap transfer.
- MeSH
- bérec chirurgie MeSH
- chirurgické laloky trendy využití MeSH
- finanční podpora výzkumu jako téma MeSH
- fraktury kostí chirurgie komplikace MeSH
- infekce měkkých tkání MeSH
- kosterní svaly chirurgie transplantace MeSH
- kotník chirurgie MeSH
- lidé MeSH
- osteomyelitida chirurgie komplikace terapie MeSH
- Check Tag
- lidé MeSH