Cílem článku je představit základní design používaných léčivých přípravků s řízeným uvolňováním léčiva pro terapii nespecifických střevních zánětlivých onemocnění a objasnit jejich chování v gastrointestinálním traktu z pohledu farmaceutické technologie. Konkrétně se zaměřuje na přípravky s obsahem 5-aminosalicylové kyseliny (Asacol®, Pentasa®, Salofalk®,) a budesonidu (Budenofalk®, Cortiment®, Entocort®). Součástí příspěvku jsou také základní doporučení a praktické informace, která lze využít v klinické praxi.
The aim of this article is to introduce the basic design of used medicinal products with controlled drug release for the treatment of inflammatory bowel diseases and to clarify their behaviour in gastrointestinal tract from the perspective of pharmaceutical technology. Specifically, it focuses on pharmaceutical drugs containing 5-aminosalicylic acid (Asacol®, Pentasa®, Salofalk®) and budesonide (Budenofalk®, Cortiment®, Entocort®). As a part of this paper, basic recommendations and practical information that can be used in clinical practice are also given.
- Keywords
- pH-depen-dentní polymery,
- MeSH
- Tablets, Enteric-Coated MeSH
- Inflammatory Bowel Diseases * drug therapy MeSH
- Drug Implants MeSH
- Delayed-Action Preparations * pharmacology therapeutic use MeSH
- Humans MeSH
- Capsules MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Prezentujeme kazuistiku 39letého muže s morbus Crohn, který po šesti letech léčby budeso-nidem (topický glukokortikoid Entocort) byl pro relabující zažívací obtíže převeden na léčbuazathioprinem (Imuran). Následně se manifestoval dosud latentní primární hypokorticismus(morbus Addisoni). Vzhledem k již známé primární hypotyreóze v terénu autoimunitní ty-reoiditis byl tedy překlasifikován na autoimunitní polyglandulární syndrom 2.
We present a case report of a 39-year-old patient with Crohn disease who was treated withbudesonide (topic glucocorticoid Entocort) for six years. Due to recurrent gastrointestinalproblems the treatment was switched to azathioprin (Imuran). Subsequently, the patientdeveloped so far latent primary hypocorticism (Addison disease). Considering that thepatient has already been diagnosed with primary hypothyroidism caused by the autoim-mune thyroiditis his diagnosis was re-classified to the autoimmune polyglandular syn-drome 2.
- MeSH
- Addison Disease diagnosis MeSH
- Polyendocrinopathies, Autoimmune * diagnosis MeSH
- Azathioprine MeSH
- Budesonide administration & dosage MeSH
- Crohn Disease drug therapy MeSH
- Adult MeSH
- Hydrocortisone blood MeSH
- Hypokalemia diagnosis etiology MeSH
- Hypothyroidism drug therapy MeSH
- Humans MeSH
- Drug Substitution MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- Keywords
- ASACOL, ENTIZOL, SALAZOPYRIN, OLSATAZIN, CYPRIDOL, RECTODELT, SALOFALK, ENTOCORT,
- MeSH
- Anti-Bacterial Agents administration & dosage therapeutic use MeSH
- Crohn Disease diagnosis etiology drug therapy MeSH
- Drug Therapy methods MeSH
- Adrenal Cortex Hormones administration & dosage therapeutic use MeSH
- Inflammatory Bowel Diseases diagnosis etiology MeSH
- Aminosalicylic Acids administration & dosage therapeutic use MeSH
- Humans MeSH
- Colitis, Ulcerative diagnosis etiology drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- Keywords
- ASACOL, SALOFALK, SALOZINAL, PENTASA, ENTOCORT, IMURAN, CONSUPREN S, RENICADE, CELTECH, CIPRINOL,
- MeSH
- Crohn Disease diagnosis etiology therapy MeSH
- Adrenal Cortex Hormones MeSH
- Immunosuppressive Agents administration & dosage therapeutic use MeSH
- Aminosalicylic Acids analogs & derivatives administration & dosage therapeutic use MeSH
- Humans MeSH
- Sulfasalazine administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
- Keywords
- ASACOL, SALOFALK, PENTASA, ENTOCORT, AZAMUN, CONSUPREN, SANDIMMUN, SANDOSTATIN, SOMATULINE,
- MeSH
- Anti-Bacterial Agents administration & dosage therapeutic use MeSH
- Crohn Disease etiology drug therapy MeSH
- Adrenal Cortex Hormones administration & dosage therapeutic use MeSH
- Inflammatory Bowel Diseases diagnosis etiology therapy MeSH
- Humans MeSH
- Mesalamine administration & dosage therapeutic use MeSH
- Proctocolitis etiology drug therapy MeSH
- Check Tag
- Humans MeSH
- Keywords
- ENTOCORT (ASTRA, ŠVÉDSKO),
- MeSH
- Crohn Disease drug therapy MeSH
- Inflammatory Bowel Diseases drug therapy MeSH
- Publication type
- Review MeSH
