Linehan, B*
Dotaz
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- MeSH
- lidé MeSH
- zdravotní politika MeSH
- zdravotní služby pro osoby s postižením * dějiny organizace a řízení zákonodárství a právo MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Irsko MeSH
- MeSH
- dospělí MeSH
- karcinom z renálních buněk genetika chirurgie patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metastázy nádorů MeSH
- míra přežití MeSH
- mladiství MeSH
- nádory ledvin genetika chirurgie patologie MeSH
- nefrektomie metody MeSH
- papilární karcinom genetika chirurgie patologie MeSH
- reoperace MeSH
- staging nádorů MeSH
- von Hippelova-Lindauova nemoc genetika chirurgie patologie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
XXI, 575 s. : il. ; 23 cm
Získání a udržování psychoterapeutických a supervizních kompetencí má pro kognitivně behaviorální terapii zásadní hodnotu. V databázích PUBMED, WEB OF SCIENCE a SCOPUS byly vyhledány články s klíčovými slovy „kognitivně behaviorální terapie“, „kompetence“, „terapeutický vztah“, „intervence“, „technika“, „trénink“, „supervize“, „sebereflexe“, „empiricky podpořeno“, „přenos“, „protipřenos“, „schéma terapie“, „dialekticko-behaviorální terapie“. Vyhledávání bylo prováděno opakováním těchto slov v různých kombinacích bez jazykového a časového omezení. Publikace pak byly probrány a následně byly dohledávány další klíčové citace z jednotlivých referencí. Také jsme použili originální texty Becka, Beckové, Padesky, Linehanové, Leahyho, Younga, Kuykenové a dalších. Literární informace jsme pak porovnávali se svojí psychoterapeutickou a supervizní zkušeností a do textu zahrnuli jen nejdůležitější informace. Jde tedy o přehledovou práci se závěry týkajícími se kompetencí v kognitivně behaviorální terapii.
Attaining and maintaining the psychotherapeutic and supervision competencies is a core value in the field of cognitive behavioral therapy. PUBMED data base was searched for articles using the key words „cognitive behavioral therapy”, „competence“, „therapeutic relations”, „intervention”, „technique”, „training”, „supervision”, „self-reflection“, „empirically supported”, „transference”, „countertransference“, „schema therapy“, „dialectical behavioral therapy“. The search was repeated by changing the key word. No language or time constraints were applied. The lists of references of articles detected by this computer data base search were examined manually to find additional articles. We also used the original texts of Beck, Beck, Padesky, Linehan, Leahy, Young, Kuyken, and others. Basically this is a review with conclusions about competencies in cognitive behavioral therapy. countertransference, schema therapy, dialectical behavioral therapy.
- Klíčová slova
- výcvik, model „krychle“, základní kompetence, specifické kompetence, supervizní kompetence, terapeutický vztah, intervence, sebe-reflexe, empirická podpora, přenos, protipřenos, schéma terapie, dialekticko-behaviorální terapie,
- MeSH
- empatie MeSH
- feedback psychologický MeSH
- kognitivně behaviorální terapie organizace a řízení výchova MeSH
- komunikace MeSH
- lidé MeSH
- odborná způsobilost MeSH
- odborný výcvik metody MeSH
- přenos (psychologie) MeSH
- protipřenos (psychologie) MeSH
- psychoterapie metody výchova MeSH
- vztahy mezi lékařem a pacientem MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- arteria pulmonalis MeSH
- krevní tlak MeSH
- plíce patofyziologie MeSH
- plicní embolie patofyziologie MeSH
- psi MeSH
- serotonin MeSH
- Check Tag
- psi MeSH
The ccA and ccB molecular subtypes of clear cell renal cell carcinoma (ccRCC) have well-characterized prognostic relevance. However, it is not known whether they possess distinct etiologies. We investigated the relationships between these subtypes and RCC risk factors within a case-control study conducted in Eastern Europe. We analyzed risk factor data for ccA (n = 144) and ccB (n = 106) cases and 1476 controls through case-only and case-control comparisons to assess risk factor differences across subtypes using logistic and polytomous regression models. We also performed a meta-analysis summarizing case-only results from our study and three patient cohorts. Patients with ccB tumors had poorer survival than those with ccA tumors and were more likely to be male (case-only odds ratio [OR] 2.68, 95% confidence interval [CI] 1.43-5.03). In case-control analyses, body mass index was significantly associated with ccA tumors (OR 2.45, 95% CI 1.18-5.10 for ≥35 vs <25 kg/m2 ) but not with ccB tumors (1.52, 0.56-4.12), while trichloroethylene was associated with ccB but not ccA (OR 3.09, 95% CI 1.11-8.65 and 1.25, 0.36-4.39 respectively for ≥1.58 ppm-years vs unexposed). A polygenic risk score of genetic variants identified from genome-wide association studies was associated with both ccA and, in particular, ccB (OR 1.82, 1.11-2.99 and 2.87, 95% CI 1.64-5.01 respectively for 90th vs 10th percentile). In a meta-analysis of case-only results including three patient cohorts, we still observed the ccB excess for male sex and the ccA excess for obesity. In conclusion, our findings suggest the existence of etiologic heterogeneity across ccRCC molecular subtypes for several risk factors.
- MeSH
- karcinom z renálních buněk klasifikace etiologie patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metaanalýza jako téma MeSH
- míra přežití MeSH
- nádory ledvin klasifikace etiologie patologie MeSH
- následné studie MeSH
- prognóza MeSH
- rizikové faktory MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
Background: This protocol outlines research to explore family members' and paid staff's perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities and their caregivers. Evidence suggests that people with intellectual and developmental disabilities experience disparities in healthcare access and utilisation. This disparity was evident early in the pandemic when discussions arose regarding the potential exclusion of this population to critical care. Methods: An anonymous online survey will be conducted with caregivers, both family members and paid staff, to explore their perceptions of the impact of COVID-19 in terms of demographics, living arrangements, access to services, social distancing, and carer wellbeing. The survey will be developed by the research team, many of whom are experts in intellectual disability within their own jurisdictions. Using back-translation our team will translate the survey for distribution in 18 countries worldwide for international comparison. The survey team have extensive personal and professional networks and will promote the survey widely on social media with the support of local disability and advocacy agencies. Statistical descriptive and comparative analyses will be conducted. Ethical approval has been obtained for this study from University College Dublin's Human Research Ethics Committee (HS-20-28-Linehan). Dissemination: Study findings will be prepared in a number of formats in order to meet the needs of different audiences. Outputs will include academic papers, lessons learned paper, practice guidelines, reports, infographics and video content. These outputs will be directed to families, frontline and management delivering disability services, national-level policy makers, healthcare quality and delivery authorities, national pandemic organisations and international bodies.
- Publikační typ
- časopisecké články MeSH
Recent years have seen important advances in our understanding of the etiology, biology and genetics of kidney cancer. To summarize important achievements and identify prominent research questions that remain, a workshop was organized by IARC and the US NCI. A series of 'difficult questions' were formulated, which should be given future priority in the areas of population, genomic and clinical research.
- MeSH
- biomedicínský výzkum MeSH
- genomika * MeSH
- lidé MeSH
- nádory ledvin etiologie genetika patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare. Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers' wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff. Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.
- Publikační typ
- časopisecké články MeSH
In the pulmonary circulation, resistive and compliant properties overlap in the same vessels. Resistance varies nonlinearly with pressure and flow; this relationship is driven by the elastic properties of the vessels. Linehan et al. correlated the mean pulmonary arterial pressure and mean flow with resistance using an original equation incorporating the distensibility of the pulmonary arteries. The goal of this study was to validate this equation in an in vivo porcine model. In vivo measurements were acquired in 6 pigs. The distensibility coefficient (DC) was measured by placing piezo-electric crystals around the pulmonary artery (PA). In addition to experiments under pulsatile conditions, a right ventricular (RV) bypass system was used to induce a continuous pulmonary flow state. The Linehan et al. equation was then used to predict the pressure from the flow under continuous flow conditions. The diameter-derived DC was 2.4%/mmHg (+/-0.4%), whereas the surface area-based DC was 4.1 %/mmHg (+/-0.1%). An increase in continuous flow was associated with a constant decrease in resistance, which correlated with the diameter-based DC (r=-0.8407, p=0.044) and the surface area-based DC (r=-0.8986, p=0.028). In contrast to the Linehan et al. equation, our results showed constant or even decreasing pressure as flow increased. Using a model of continuous pulmonary flow induced by an RV assist system, pulmonary pressure could not be predicted based on the flow using the Linehan et al. equation. Measurements of distensibility based on the diameter of the PA were inversely correlated with the resistance.
