Half-inhibition concentrations of new cholinesterase inhibitors
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Butyrylcholinesterase blood metabolism MeSH
- Cholinesterase Inhibitors chemistry pharmacology MeSH
- Carbamates MeSH
- Kinetics MeSH
- Horses MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
- Carbamates MeSH
The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. The determined pI50 values (= negative logarithm of the molar concentration inhibiting the enzyme activity by 50%) of the tested substances were compared with pI50 values of the commercially used drugs for the Alzheimer's disease treatment--rivastigmine and galanthamine.
References provided by Crossref.org
Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors
2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase
Proline-Based Carbamates as Cholinesterase Inhibitors
Novel Cholinesterase Inhibitors Based on O-Aromatic N,N-Disubstituted Carbamates and Thiocarbamates
1,3-substituted imidazolidine-2,4,5-triones: synthesis and inhibition of cholinergic enzymes
