Malleable mitochondrion of Trypanosoma brucei
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
Canadian Institutes of Health Research - Canada
PubMed
25708462
DOI
10.1016/bs.ircmb.2014.11.001
PII: S1937-6448(14)00009-4
Knihovny.cz E-resources
- Keywords
- Kinetoplast, Metabolism, Mitochondrial transport, Mitochondrion, RNA import, T. brucei, Trypanosome, kDNA,
- MeSH
- Biological Transport MeSH
- Humans MeSH
- DNA, Mitochondrial genetics MeSH
- Mitochondrial Dynamics MeSH
- Mitochondrial Proteins metabolism MeSH
- Mitochondria metabolism MeSH
- Trypanosoma brucei brucei genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- DNA, Mitochondrial MeSH
- Mitochondrial Proteins MeSH
The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases. We present a comprehensive survey of its mitochondrial pathways including kinetoplast DNA replication and maintenance, gene expression, protein and metabolite import, major metabolic pathways, Fe-S cluster synthesis, ion homeostasis, organellar dynamics, and other processes. As we describe in this chapter, the single mitochondrion of T. brucei is everything but simple and as such rivals mitochondria of multicellular organisms.
Faculty of Sciences University of South Bohemia České Budějovice Czech Republic
Institute of Parasitology Biology Centre Czech Academy of Sciences Czech Republic
References provided by Crossref.org
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