A right-sided hemothorax is a rare manifestation of an acute type b aortic dissection that has been covered in the available references in only a few cases. this case report covers the case of a 58-year-old man hospitalized for acute pain in the epigastrium with severe hypotension and sopor. An acute type b dissection manifested by an isolated right-sided hemothorax with concurrent oppression of the left atrium of the heart and pulmonary veins by a mediastinal hematoma was diagnosed. cardiovascular syphilis was diagnosed as the probable causal agent of the dissection. the acute situation was resolved by the implantation of a stent graft and evacuation of hematoma from the right-sided thoracotomy.
- MeSH
- akutní bolest břicha etiologie MeSH
- bolesti na hrudi etiologie MeSH
- cévní protézy MeSH
- disekce aorty * chirurgie diagnóza etiologie klasifikace komplikace terapie MeSH
- hematom chirurgie diagnóza MeSH
- hemotorax chirurgie etiologie MeSH
- hypotenze etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- noradrenalin aplikace a dávkování MeSH
- počítačová rentgenová tomografie MeSH
- poruchy vědomí etiologie MeSH
- srdeční síně patologie MeSH
- syfilis kardiovaskulární chirurgie diagnóza komplikace terapie MeSH
- tachykardie etiologie MeSH
- torakotomie MeSH
- venae pulmonales patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- Publikační typ
- abstrakt z konference MeSH
AIMS: Visfatin (NAMPT/PBEF) is a recently identified adipocytokine which harbors strong insulin-mimetic activity and was reported to be associated with obesity. However, nothing is known about whether visfatin is related to specific nutritional behavior which may result in obesity development. This is the first study focusing on genetic variability of the visfatin gene and its association with circulating visfatin, anthropometric parameters and dietary composition. MATERIALS AND METHODS: We analyzed a total of 11 exons and adjacent non-coding regions of the NAMPT gene in 20 extremely obese Czech individuals (mean BMI 52.2±5.0 SD) using direct sequencing and a frequency of rs2302559 was established in the validation cohort of another 605 individuals with completed 7-day food records and complex anthropometric measurements. Serum levels of visfatin, leptin and leptin-receptor were measured in all sequenced individuals and in part of the validation cohort. RESULTS: Three common polymorphisms were identified, two in non-coding regions (rs78411774 A/C, rs71564769 A/C) and one synonymous SNP in exon 7 (rs2302559 A/G). The rs2302559 showed significant correlation with visfatin serum level throughout the entire study cohort (p<0.001); there was a significant tendency toward higher visfatin levels in G allele carriers with GG homozygotes having the highest visfatin serum levels. Furthermore, a negative correlation was observed between visfatin and leptin serum level (p=0.01). No association between investigated SNPs and anthropometric parameters or native dietary composition was observed. CONCLUSION: This is the first study to demonstrate that the rs2302559 polymorphism in the PBEF gene is related to circulating levels of visfatin. As the SNP is synonymous, we hypothesize it might be linked to another SNP in the PBEF gene which controls visfatin serum levels.
- MeSH
- antropometrie MeSH
- běloši genetika MeSH
- cytokiny genetika metabolismus MeSH
- dieta * MeSH
- dietní záznamy MeSH
- hubenost MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus * MeSH
- krevní glukóza metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- nikotinamidfosforibosyltransferasa genetika metabolismus MeSH
- obezita epidemiologie genetika metabolismus MeSH
- sekvenční analýza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- validační studie MeSH
- Geografické názvy
- Česká republika MeSH
Visfatin, a product of PBEF gene, is an adipocytokine that harbours strong insulin-mimetic activity and it has been reported previously to associate with obesity. Recent reports also provide evidence that Visfatin has also important intracellular effects as it is homologous with nicotinamide phosphoribosyltransferase (NAMPT). In this review, we summarize the main documented effects of Visfatin on metabolism in humans, with special emphasis put on the pathways associated with obesity.
- MeSH
- beta-buňky metabolismus MeSH
- cytokiny metabolismus MeSH
- inzulinová rezistence * MeSH
- lidé MeSH
- lipidy krev MeSH
- nikotinamidfosforibosyltransferasa metabolismus farmakologie MeSH
- obezita metabolismus MeSH
- tuková tkáň metabolismus MeSH
- zánět metabolismus MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The authors address the situation in foreign objects in the patient's bodies after a surgery in CZ and worldwide. They provide current data from the literature, such as that for example a surgical drape is left approximately once a year in a medium size hospital and related mortality is 50%. (No such data have been obtained in the Czech Republic). The authors have sent a questionnaire to all healthcare facilities n CZ with response rate of 5 out of 150. This fact makes them believe that the healthcare professionals in surgical fields have not yet understand that sharing a negative experience can motivate other colleagues to prevent similar mistakes.
- MeSH
- chirurgické nástroje škodlivé účinky MeSH
- chirurgie operační škodlivé účinky MeSH
- chrániče úst statistika a číselné údaje škodlivé účinky využití MeSH
- chybná zdravotní péče statistika a číselné údaje škodlivé účinky MeSH
- infekce v ráně etiologie mortalita prevence a kontrola MeSH
- lidé MeSH
- mortalita MeSH
- primární prevence MeSH
- průzkumy a dotazníky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
- Geografické názvy
- Česká republika MeSH
