Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (DM2) are the most common endocrinological diseases worldwide. Relation between these diseases explains several hypotheses. One of them is influence of some adipocytokines. This study evaluated association between three adipocytokines (adiponectin, resistin and visfatin) and thyroid and glycid status in patients with DM2 and AIT compared to the control group (CG). The group consisted of four subgroups: patients with DM2 without thyreopathies, patients with AIT on substitution therapy without diabetes and prediabetes, patients with DM2 and AIT on substitution therapy and healthy subjects as the CG. We investigated parameters of thyroid and glucose metabolism and serum levels of three adipocytokines. The mean level of resistin in the group of patients with diabetes and thyroiditis was significantly higher than in patients with thyroiditis without diabetes and than in the CG. We found a weak negative correlation between visfatin and fasting glucose levels in patients with thyroiditis without diabetes. We detected a weak negative correlation between resistin and glycated haemoglobin and a weak negative correlation between visfatin and thyroid gland volume in patients with diabetes without thyroiditis. In the CG we determined a weak positive correlation between visfatin and free thyroxin. Our results are consistent with several studies, which confirmed association between AIT and adipocytokines.
- MeSH
- adipokiny krev MeSH
- autoimunitní tyreoiditida krev komplikace diagnostické zobrazování MeSH
- cytokiny krev MeSH
- diabetes mellitus 2. typu krev komplikace MeSH
- dospělí MeSH
- glykovaný hemoglobin metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nikotinamidfosforibosyltransferasa krev MeSH
- senioři MeSH
- štítná žláza diagnostické zobrazování MeSH
- studie případů a kontrol MeSH
- ultrasonografie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Trends in dietary nutrition and their personalization are progress in medical science and point out the necessity of adaptation and development of innovations in health system. The main objective of this article is to review the role of dietary fibre as prebiotics in nutrition with different functionality, its influence on modulation of intestinal microbiota, which has an essential role in maintenance of healthy organisms in people of all ages.
BACKGROUND: Obesity and overweight are major contributors to the global burden of chronic diseases and disability in both majority and minority populations. METHODS: Data from the cross-sectional population-based HepaMeta study conducted in Slovakia in 2011 were used. The sample comprised a total of 452 Roma. Measurements of special bioactive mediators were taken in final groups consisting of 63 male Roma respondents (mean age = 32.59; SD = 8.63) and 117 female Roma respondents (mean age = 34.55; SD = 8.35). Respondents were divided into three groups: those with normal weight, those with overweight and obese. Values for anthropometric parameters, lipids parameters, C-reactive protein, TNF-alpha, IL-6, leptin, and adiponectin were determined. RESULTS: 27.6% of examined Roma females and 26.9% of males were overweight. Obesity (BMI > 30.0 kg/m2) appeared in a higher proportion of males (28.8%) compared with female (26.5%). Mean levels of total cholesterol, triacylglycerol and LDL-cholesterol were significantly elevated in the overweight and obese subjects compared to normal-weight Roma respondents. The relation was reversed for HDL-C level, with significantly decreased levels in both male and female obese Roma (p < 0.001). The concentration of adiponectin was significantly lower in obese subjects of both genders versus non-obese (Roma male p < 0.001, Roma female p < 0.05). Plasma levels of leptin, IL-6, hs-CRP as well as TNF-alpha increased in Roma significantly with increasing BMI. CONCLUSION: The study is the first one to provide data about selected biomarkers. Results may be useful in predicting obesity and its related diseases in the Roma population from the eastern part of Slovakia.
- MeSH
- adiponektin krev MeSH
- biologické markery krev MeSH
- C-reaktivní protein MeSH
- dospělí MeSH
- index tělesné hmotnosti MeSH
- interleukin-6 krev MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipidy krev MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nadváha krev etnologie MeSH
- obezita krev etnologie MeSH
- průřezové studie MeSH
- Romové etnologie statistika a číselné údaje MeSH
- rozložení podle pohlaví MeSH
- TNF-alfa krev MeSH
- venkovské obyvatelstvo statistika a číselné údaje MeSH
- zdravotnické přehledy metody statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Slovenská republika MeSH
The aim of our study was to evaluate the effects of the different probiotic strains, Lactobacillus plantarum LS/07 and Lactobacillus plantarum Biocenol LP96, on lipid metabolism and body weight in rats fed a high fat diet. Compared with the high fat diet group, the results showed that Lactobacillus plantarum LS/07 reduced serum cholesterol and LDL cholesterol, but Lactobacillus plantarum Biocenol LP96 decreased triglycerides and VLDL, while there was no change in the serum HDL level and liver lipids. Both probiotic strains lowered total bile acids in serum. Our strains have no significant change in body weight, gain weight, and body fat. These findings indicate that the effect of lactobacilli on lipid metabolism may differ among strains and that the Lactobacillus plantarum LS/07 and Lactobacillus plantarum Biocenol LP96 can be used to improve lipid profile and can contribute to a healthier bowel microbial balance.
- MeSH
- dieta s vysokým obsahem tuků * MeSH
- glukuronidasa metabolismus MeSH
- krysa rodu rattus MeSH
- Lactobacillus plantarum enzymologie metabolismus MeSH
- lipidy krev MeSH
- metabolismus lipidů * MeSH
- probiotika aplikace a dávkování metabolismus MeSH
- tělesná hmotnost MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- ambulantní monitorování metody statistika a číselné údaje využití MeSH
- ateroskleróza diagnóza etiologie prevence a kontrola MeSH
- dítě MeSH
- financování organizované MeSH
- klinické laboratorní techniky metody statistika a číselné údaje využití MeSH
- lidé MeSH
- prevalence MeSH
- rizikové faktory MeSH
- statistika jako téma MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
