Introduction. Vagal nerve stimulation (VNS) is a therapeutical option for the treatment of drug-resistant epileptic patients. The response to VNS varies from patient to patient and is difficult to predict. The proposed study is based on our previous work, identifying relative mean power in pre-implantation EEG as a reliable marker for VNS efficacy prediction in adult patients. Our study has two main tasks. Firstly, to confirm the utility of relative mean power as a feature correlating with VNS efficacy in children. The second is to validate the applicability of our prediction classifier, Pre-X-Stim, in the pediatric population. Material and Methods. We identified a group of children with drug-resistant epilepsy. We included only children in whom EEG contained photic stimulation (Task 1) or was recorded based on the defined acquisition protocol used for development Pre-X-Stim (Task 2). Relative mean powers were calculated. VNS responders and non-responders were compared based on relative mean powers' values. In the next step, we evaluate the utility of our classifier, Pre-X-Stim, in the children population. Results: We identified 57 children treated with VNS - 17 patients were recruited for the Task 1 and 7 patients for the Task 2. When focusing on relative mean powers in EEG spectra, we observed statistically significant differences in theta range. The Pre-X-Stim algorithm was able to predict VNS efficacy correctly in 6 out of 7 patients (the accuracy 83.3%, the sensitivity 75%, the specificity 100%). Conclusions. Based on our results, it seems that children and adults share a similar pattern of EEG relative mean power changes. These changes can be used for pre-implantation prediction of VNS efficacy.

• MeSH
• dítě MeSH
• elektroencefalografie * metody   MeSH
• epilepsie * terapie   patofyziologie   MeSH
• lidé MeSH
• mladiství MeSH
• předškolní dítě MeSH
• refrakterní epilepsie * terapie   patofyziologie   MeSH
• skalp MeSH
• vagová stimulace * metody   MeSH
• výsledek terapie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f1 and f2 > 1 kHz) interfere to create an envelope-modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency: Δf = |f2 - f1|. OBJECTIVE: The goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Δf and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD). METHODS: DBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f1 = 9.00 kHz; f2 = 9.13 kHz, 4 mA peak-peak per pair maximum) of scalp electrodes placed in temporoparietal regions to focus the envelope signal maximum (Δf = 130 Hz) at the motor part of the STN target. RESULTS: The comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients. CONCLUSIONS: TIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

• MeSH
• beta rytmus EEG * fyziologie   MeSH
• hluboká mozková stimulace * metody   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nucleus subthalamicus * patofyziologie   MeSH
• Parkinsonova nemoc * terapie   patofyziologie   MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Navrhovaný projekt se zaměřuje na predikci efektu neurostimulačních metod (vagové stimulace, hluboké mozkové stimulace) u pacientů s epilepsií. V současnosti je známo, že neurostimulační metody vedou k významné redukci záchvatů cca u 50% implantovaných pacientů. Dosud však nejsme schopni pacienty, kteří profitují z implantace neurostimulátoru, identifikovat na základě jejich předimplantačních dat. Našemu kolektivu se podařilo vyvinout statistický model, který predikuje efekt vagové stimulace na základě rutinního EEG, které bylo natočeno před implantací. Tento statistický model predikuje efekt vagové stimulace s vysokou sensitivitou a specificitou. Nynější projekt vychází z tohoto statistického modelu, snahou je vytvořit obdobný model pro děti s implantovaný vagovým stimulátorem a pro pacienty s hlubokou mozkovou stimulací. Současně si rovněž uvědomujeme nutnost otestovat statistický model na externích datech, toto testování vnímáme jako zásadní pro jeho klinické využití. Projekt se zaměřuje na zlepšení péče o pacienty s farmakorezistentní epilepsií.; Proposed project is focused on the prediction of neurostimulation methods (vagal nerve stimulation, deep brain stimulation) efficacy in patients with epilepsy. Neurostimulation leads to significant seizure reduction in approximately 50% of implanted patient. By now, we are not able to identify patients who can benefit from implantation of neurostimulator pre-operatively. We managed to develop a statistic mode, which is able to predict efficacy of vagal nerve stimulation based on routine pre-implantation EEG. This statistic model predict efficacy of vagal nerve stimulation with high sensitivity and specificity. Proposed project is based on this statistic model, we would like to develop similar model for children with implanted vagal nerve stimulator and for patients with deep brain stimulation. At the same time, we realize the necessity to verify our statistic model on independent external data set, which we supposed to be crucial for the clinical application. The project is focused on the improvement of medical care in patients with drug-resistant epilepsy.

• Klíčová slova
• epilepsie, epilepsy, neurostimulace, Neurostimulation, hluboká mozková stimulace, deep brain stimulation, stimulace vagového nervu, predikce efektu, statistický model, vagal nerve stimulation, efficacy prediction, statistic model,

• NLK Publikační typ
• závěrečné zprávy o řešení grantu AZV MZ ČR

Úmrtí císaře Montezumy zřejmě na následky kraniocerebrálního poranění nepochybně předznamenalo konec aztécké říše. Ovšem vlastní pád aztécké říše zásadnějším způsobem ovlivnilo jiné kraniocerebrální poranění a především jeho úspěšná léčba - otevřená, zřejmě kontaminovaná impresivní fraktura kalvy španělského konquistadora Hernanda Cortése, o které překvapivě existují pouze omezené literární prameny. Po úspěšné operační léčbě se Hernando Cortés znovu ujal velení armády, se kterou dobyl aztécké hlavní město, a ukončil tak existenci aztécké říše. Jeho další výboje pak dostaly do španělského područí nejen velkou část Střední Ameriky s jejím bohatstvím, což ovlivnilo španělskou i světovou historii.

The death of Emperor Montezuma, apparently from craniocerebral injury, undoubtedly marked the end of the Aztec Empire. However, another craniocerebral injury affected the Aztec empire's downfall in a more fundamental way, and, above all, its successful treatment - the open, apparently contaminated, impresive calvarial fracture of Spanish conquistador Hernando Cortés, of which, surprisingly, there are only limited literary sources. After successful surgical treatment, Hernando Cortés resumed command of the army with which he captured the Aztec capital, ending the existence of the Aztec Empire. His other conquests then brought not only much of Central America with its riches into Spanish thrall, affecting not only Spanish but also world history.

• Klíčová slova
• Montezuma, hernando Cortés,
• MeSH
• dějiny 16. století MeSH
• kraniocerebrální traumata * chirurgie   dějiny   MeSH
• lidé MeSH
• neurochirurgické výkony dějiny   metody   MeSH
• trepanace dějiny   MeSH
• vpáčené fraktury lebky chirurgie   dějiny   MeSH
• Check Tag
• dějiny 16. století MeSH
• lidé MeSH
• Publikační typ
• historické články MeSH

Beta hypersynchrony was recently introduced into clinical practice in Parkinson's disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication "off" state. Coupling between beta power and HFOs is known to be a correlate of the PD "off" state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.

• Publikační typ
• časopisecké články MeSH

PURPOSE: Despite the best efforts of neurologists, the results of pharmacotherapy in the late stages of Parkinson's disease are often disappointing and accompanied by debilitating side effects. Under these circumstances, deep brain stimulation is a viable treatment option. The aim of the meticulous pre-surgical planning is not only precise electrode implantation, but also the avoidance of intraoperative vascular conflicts potentially causing intracerebral bleeding. MATERIAL AND METHODS: In this report, we present a patient with early-onset Parkinson's disease whose cerebral vascular anatomy precluded standard bilateral subthalamic nucleus electrode implantation. Initially, right subthalamic stimulation alone provided a very mild clinical benefit that was not reflected in the patient's quality of life. In this patient, an unusual configuration of intracerebral electrodes with right subthalamic and left pallidal stimulation electrodes was applied 15 months after the initial subthalamic electrode implantation. RESULTS: The procedure has had a highly beneficial long-term effect without any significant complications. The greatest improvement was noted using the setting 1.8 V, 130 Hz, 90 μs at the right side (STN) and 3.7 V, 130 Hz, 120 μs at the left side (GPi). This allowed the patient to return to his daily life activities. CONCLUSIONS: The reported case provides a new perspective of treatment possibilities in complex functional neurosurgical cases requiring exceptional individualisation of the treatment approach.

• MeSH
• elektrody MeSH
• hluboká mozková stimulace * metody   MeSH
• kvalita života MeSH
• lidé MeSH
• Parkinsonova nemoc * terapie   komplikace   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Deep brain stimulation (DBS) is an established method in the treatment of not only Parkinson's disease motor complications but also dystonia and tremor, and there are data supporting the efficacy of DBS in epilepsy and some psychiatric problems. The alleviation of the neurologic problems may enable females of childbearing age to consider pregnancy because of being able to take care of their child. The aim of the study is to provide a review of the data available on the effect of DBS on the course of pregnancy and delivery in patients suffering from diseases amenable for DBS treatment (Parkinson's disease, dystonia, obsessive compulsive disorder, Tourette's syndrome, epilepsy). Although data available in the literature on pregnancy and childbirth in patients with an implanted active DBS system are limited to small case series and case reports, the number of younger patients implanted with DBS systems will potentially require more attention beyond specialized DBS centers. In emergency deliveries, general obstetricians and neurosurgeons should be provided with a protocol to prevent injuries to the implanted system with potentially devastating consequences for the patient.

• MeSH
• dítě MeSH
• dystonie * terapie   MeSH
• epilepsie * terapie   MeSH
• hluboká mozková stimulace * metody   MeSH
• lidé MeSH
• Parkinsonova nemoc * terapie   MeSH
• těhotenství MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• Publikační typ
• abstrakt z konference MeSH

Introduction: On average, diabetic foot ulcerations heal within 3 to 6 months. By adhering to treatment measures this period can be shortened and re-ulcerations prevented. Aims: To analyze the causes and risk factors of re-ulcerations/recurrences/relapses of diabetic foot ulcers (DFU) on 1 case, to assess the effects of the applied treatment measures, and to suggest more effective methods to maintain motivation to treatment and successful healing of diabetic ulcerations.Methods: A case study of a client diagnosed with DFU who was monitored, treated and educated in a vascular-surgical outpatient ward for 11 years (2010-2021). For data collection we used monitoring, tests and scales, an interview, a medical documentation analysis including laboratory, physical, clinical and anthropometric indicators, and a DFU photo documentation.Result: A long-term DFU treatment (local surgical and wound therapy, pharmacological, short education about regimen measures) caused the client's loss of motivation and non- adherent behavior manifested by his nonadherence to the prescribed regimen measures (diet, relieving the ulcers), worsening of laboratory indicators (HbA1c), physical indicators (hypertension), clinical indicators (nonhealing scum of the wound, re-ulceration, infection), anthropometric indicators (BMI), insufficient treatment efficacy, and worsening of the prognosis of DFU (amputation). The fact that there were no physical inspections during the covid pandemic made this condition even worse.Conclusion: Despite a long DFU treatment the client's DFU did not heal. Such a long- term patient must not only be educated but also led and supported, positively motivated to undergo treatment and to adhere to the regimen measures through life values, individual lifestyle, and open partnership with healthcare professionals.

• MeSH
• adherence pacienta * MeSH
• diabetická noha * terapie   MeSH
• lidé MeSH
• longitudinální studie MeSH
• neúspěšná terapie MeSH
• rizikové faktory MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• kazuistiky MeSH

Introduction: On average, diabetic foot ulcerations heal within 3 to 6 months. By adhering to treatment measures this period can be shortened and re-ulcerations prevented. Aims: To analyze the causes and risk factors of re-ulcerations/recurrences/relapses of diabetic foot ulcers (DFU) on 1 case, to assess the effects of the applied treatment measures, and to suggest more effective methods to maintain motivation to treatment and successful healing of diabetic ulcerations.Methods: A case study of a client diagnosed with DFU who was monitored, treated and educated in a vascular-surgical outpatient ward for 11 years (2010-2021). For data collection we used monitoring, tests and scales, an interview, a medical documentation analysis including laboratory, physical, clinical and anthropometric indicators, and a DFU photo documentation.Result: A long-term DFU treatment (local surgical and wound therapy, pharmacological, short education about regimen measures) caused the client's loss of motivation and non- adherent behavior manifested by his nonadherence to the prescribed regimen measures (diet, relieving the ulcers), worsening of laboratory indicators (HbA1c), physical indicators (hypertension), clinical indicators (nonhealing scum of the wound, re-ulceration, infection), anthropometric indicators (BMI), insufficient treatment efficacy, and worsening of the prognosis of DFU (amputation). The fact that there were no physical inspections during the covid pandemic made this condition even worse.Conclusion: Despite a long DFU treatment the client's DFU did not heal. Such a long- term patient must not only be educated but also led and supported, positively motivated to undergo treatment and to adhere to the regimen measures through life values, individual lifestyle, and open partnership with healthcare professionals.

• MeSH
• adherence pacienta * MeSH
• diabetická noha * MeSH
• longitudinální studie MeSH
• neúspěšná terapie MeSH
• rizikové faktory MeSH
• senioři MeSH
• Check Tag
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• kazuistiky MeSH