The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper summarizes the ERA Registry Annual Report 2022, with a special focus on comparisons by sex. The supplement of this paper contains the complete ERA Registry Annual Report 2022. Data was collected from 53 national and regional KRT registries from 35 countries. Using this data, incidence, and prevalence of KRT, kidney transplantation rates, survival probabilities, and expected remaining lifetimes were calculated. In 2022, 530 million people of the European general population were covered by the ERA Registry. The incidence of KRT was 152 per million population (pmp). In incident patients, 54% were 65 years or older, 64% were male, and the most common primary renal disease (PRD) was diabetes mellitus (22%). At KRT initiation, 83% of patients received haemodialysis, 12% received peritoneal dialysis, and 5% underwent pre-emptive kidney transplantation. On 31 December 2022, the prevalence of KRT was 1074 pmp. In prevalent patients, 48% were 65 years or older, 62% were male, the most common PRD was of miscellaneous origin (18%), 56% of patients received haemodialysis, 5% received peritoneal dialysis, and 39% were living with a functioning graft. In 2022, the kidney transplantation rate was 40 pmp, with most kidneys coming from deceased donors (66%). For patients starting KRT between 2013 to 2017, 5-year survival probability was 52%. Compared with the general population, the expected remaining lifetime was 66% and 68% shorter for males and females, respectively, receiving dialysis, and 46% and 49% shorter for males and females, respectively, living with a functioning graft.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
BACKGROUND: Chronic kidney disease (CKD) has a global prevalence of 9.1-13.4%. Comorbidities are abundant and may cause and affect CKD. Cardiovascular disease strongly correlates with CKD, increasing the burden of both diseases. SUMMARY: As a group of 15 clinical nephrologists primarily practicing in 12 Central/Eastern European countries, as well as Israel and Kazakhstan, herein we review the significant unmet needs for patients with CKD and recommend several key calls-to-action. Early diagnosis and treatment are imperative to ensure optimal outcomes for patients with CKD, with the potential to greatly reduce both morbidity and mortality. Lack of awareness of CKD, substandard indicators of kidney function, suboptimal screening rates, and geographical disparities in reimbursement often hamper access to effective care. KEY MESSAGES: Our key calls-to-action to address these unmet needs, thus improving the standard of care for patients with CKD, are the following: increase disease awareness, such as through education; encourage provision of financial support for patients; develop screening algorithms; revisit primary care physician referral practices; and create epidemiological databases that rectify the paucity of data on early-stage disease. By focusing attention on early detection, diagnosis, and treatment of high-risk and early-stage CKD populations, we aim to reduce the burdens, progression, and mortality of CKD.
- MeSH
- časná diagnóza * MeSH
- chronická renální insuficience * terapie diagnóza MeSH
- lidé MeSH
- nefrologové * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
- východní Evropa MeSH
Metabolický syndróm (MS) je komplex vzájomne súvisiacich rizikových faktorov pre kardiovaskulárne ochorenia a diabetes mellitus 2. typu. Viaceré štúdie potvrdili aj asociáciu medzi MS a chronickou chorobou obličiek (CKD – Chronic Kidney Disease). Základom MS je inzulínová rezistencia a metabolicky indukovaný zápal pri expanzii viscerálneho tukového tkaniva. Ďalšími patogenetickými faktormi pri poškodení obličiek sú nerovnováha v produkcii adipokínov, aktivácia systému renín-angiotenzín-aldosterón a sympatického nervového systému, zvýšená koncentrácia endotelínu 1, dysfunkcia mitochondrií, oxidačný stres a kompresia renálneho parenchýmu v dôsledku nahromadenia perirenálneho tuku. Výsledkom pôsobenia týchto faktorov je hyperfiltrácia v glomeruloch, endotelová dysfunkcia, poškodenie podocytov, expanzia mezangia, glomeruloskleróza, atrofia tubulov a intersticiálna fibróza. Objasnenie mechanizmov, ktorými MS navodzuje poškodenie obličiek, je kľúčom k prevencii vzniku a progresie CKD.
Metabolic syndrome (MS) is a complex of interrelated risk factors for cardiovascular disease and type 2 diabetes mellitus. Several studies have also confirmed the association between MS and chronic kidney disease (CKD). The basis of MS is insulin resistance and metabolically induced inflammation in the expansion of visceral adipose tissue. Other pathogenetic factors in renal damage are imbalance in adipokine production, activation of the renin-angiotensin- aldosterone system and the sympathetic nervous system, increased endothelin 1 concentration, mitochondrial dysfunction, oxidative stress, and compression of the renal parenchyma due to accumulation of perirenal fat. These factors result in glomerular hyperfiltration, endothelial dysfunction, podocyte damage, mesangial expansion, glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Elucidating the mechanisms by which MS induces renal damage is crucial to prevent the onset and progression of CKD.
Diabetes a obezita, ISSN 1335-8383 Ročník 21, Suplement 1, máj 2021
13 stran : tabulky ; 27 cm
- MeSH
- diabetické nefropatie MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- diabetologie
- nefrologie
Forum diabetologicum, ISSN 1805-3807 Ročník 10, supplementum 2, 2021
279 stran : ilustrace ; 27 cm + brožura Inzertná príloha
- MeSH
- diabetes mellitus diagnóza terapie MeSH
- komorbidita MeSH
- komplikace diabetu diagnóza terapie MeSH
- Publikační typ
- sborníky MeSH
- směrnice pro lékařskou praxi MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- diabetologie
Forum diabetologicum, ISSN 1805-3807 Ročník 7, číslo 2, supplementum 1, 2018
153 stran : ilustrace (některé barevné) ; 27 cm
Směrnice určující standardy v léčbě a diagnostice diabetes mellitus, včetně komplikací.
- MeSH
- diabetes mellitus diagnóza terapie MeSH
- komorbidita MeSH
- mezioborová komunikace MeSH
- Publikační typ
- sborníky MeSH
- směrnice pro lékařskou praxi MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- diabetologie
