OBJECTIVES: The aim of our study is to measure very low frequency band (VLF), low frequency band (LF) and high frequency band (HF) components of R-R interval during orthostatic test in patients with panic disorder and a comparison with healthy controls. METHODS: We measured HRV in 31 patients with panic disorder and 20 healthy controls. Diagnosis was done according to the ICD-10 research diagnostic criteria confirmed with MINI (MINI international neuropsychiatric interview). Autonomic nervous system (ANS) has been evaluated during orthostatic change in three positions. Intensity of symptoms was assessed using psychiatric scales. RESULTS: There were highly statistically significant differences between panic patients and control group in all components of power spectral analysis in 2nd and 3rd VLF components and in HF components of 2nd. We have found highly statistically significant negative correlations between level of dissociation measured by DES and some parameters of ANS. We found negative correlations between the age of the patient and activity of ANS, and negative correlations between activity of ANS and duration and onset of disorder and dosage of antidepressants. CONCLUSION: These findings demonstrate a lower parasympathetic activity and higher sympathetic/parasympathetic ratio in panic disorder patients measured during the changes of postural position in comparison with healthy controls. Autonomic dysregulation is associated with panic disorder and has the relation with the level of dissociation, the age of patiens and age of onset of disorder.

• MeSH
• antidepresiva farmakologie   terapeutické užití   MeSH
• autonomní nervový systém patofyziologie   MeSH
• disociační poruchy patofyziologie   MeSH
• dospělí MeSH
• elektrokardiografie účinky léků   psychologie   statistika a číselné údaje   MeSH
• lidé MeSH
• panická porucha farmakoterapie   patofyziologie   MeSH
• postura těla fyziologie   MeSH
• psychiatrické posuzovací škály statistika a číselné údaje   MeSH
• srdeční frekvence účinky léků   fyziologie   MeSH
• studie případů a kontrol MeSH
• věkové faktory MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

PURPOSE OF THE STUDY Repeated measurements of the spine are absolutely necessary in children and adolescents affected by spinal deformities especially during their growing-up periods. To avoid risks of tissue damage from x-ray exposure, several methods for non-invasive measurement of the spinal curvature have been developed. One of them is the DTP-3 position system allowing for a three-dimensional measurement of anatomical landmarks (spinous processes) and the calculation of curvature angles in both the frontal and sagittal planes. We were interested to know whether the DTP-3 was precise enough to determine the true spinal curvature. MATERIAL AND METHODS To determine the precision of the DTP-3 system, we constructed a model of the spine. The model was then repeatedly investigated by both the noninvasive and x-ray methods. The distortion of x-ray images caused by the central projection mechanism was considered and included in the calculation. In addition, a group of patients with scoliosis up to 40° was evaluated by both the DTP-3 system and x-ray (the latter according to Cobb's method). RESULTS Differences in spatial coordinates between DTP-3 and x-ray examinations reached 20.9 mm in the frontal plane and 67.3 mm in the sagittal plane without distortion correction of x-ray images. The differences decreased below 1.5 mm after image distortion correction in each plane. Distortion correction had not the same effect for angle parameters as for coordinates. Differences between the DTP-3 angle parameters and Cobb's x-ray angles were below 4.7°, both without correction and after correction. The difference between DTP-3 angle parameters and Cobb's x-ray angles was -1.8° ? 3.0° (mean ? standard deviation) when measurement was performed on the patients with scoliosis. DISCUSSION The goal of any clinical examination is to obtain data applicable to decision-making analysis. In the case of scoliosis it is necessary to report results in terms of Cobb's angle, which is the problem for all surface-dependent methods, especially in patients with double curves. A solution may be to define the maximal difference between noninvasive and x-ray methods that could be acceptable for good clinical practice. CONCLUSIONS In this study we report good concordance between noninvasive and x-ray examinations of a modeled spinal deformity in terms of both angle and linear measurements. The same results were obtained for angle measurements in a group of patients with scoliosis up to 40°. Based on this study and our previous data we believe that the DTP-3 system can be introduced into clinical practice.

• MeSH
• lidé MeSH
• mladiství MeSH
• modely anatomické MeSH
• páteř patologie   radiografie   MeSH
• počítačové zpracování obrazu MeSH
• skolióza diagnóza   radiografie   MeSH
• software MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• srovnávací studie MeSH
• validační studie MeSH

To decrease the influence of postural sway during spinal measurements, an instrumented fixation posture (called G) was proposed and tested in comparison with the free standing posture (A) using the DTP-3 system in a group of 70 healthy volunteers. The measurement was performed 5 times on each subject and each position was tested by a newly developed device for non-invasive spinal measurements called DTP-3 system. Changes in postural stability of the spinous processes for each subject/the whole group were evaluated by employing standard statistical tools. Posture G, when compared to posture A, reduced postural sway significantly in all spinous processes from C3 to L5 in both the mediolateral and anterioposterior directions. Posture G also significantly reduced postural sway in the vertical direction in 18 out of 22 spinous processes. Importantly, posture G did not significantly influence the spinal curvature.

• Publikační typ
• časopisecké články MeSH

OBJECTIVES: Alarming somatic symptoms and in particular the cardiovascular symptoms, are the characteristic features of panic attacks. Increased cardiac mortality and morbidity have been proposed in these patients. Power spectral analysis of electrocardiogram R-R intervals is known to be a particularly successful tool in the detection of autonomic instabilities in various clinical disorders. Heart rate variability (HRV) has been found to be the outcome of rapidly reacting cardiovascular control systems. The aim of our study is to measure very low frequency band (VLF), low frequency band (LF) and high frequency band (HF) components of R-R interval during orthostatic experiment in patients with panic disorder before and after treatment and compares it with healthy controls. METHODS: We assessed heart rate variability in 19 patients with panic disorder before and after 6-weeks treatment with antidepressants combined with cognitive behavioral therapy (CBT) and in 18 healthy controls. Diagnosis was done according to the ICD-10 research diagnostic criteria confirmed with MINI (MINI international neuropsychiatric interview). Patients were treated with CBT and psychotropics. They were regularly every week assessed using CGI (Clinical Global Impression), BAI (Beck Anxiety Inventory) and BDI (Beck Depression Inventory). Heart rate variability was assessed during 3 positions (1st - 5 min supine; 2nd - 5 min standing; 3rd - 5 min supine) before and after the treatment. Power spectra were computed for very low frequency - VLF (0.0033-0.04 Hz), low-frequency - LF (0.04-0.15 Hz) and high frequency - HF (0.15-0.40 Hz) bands using fast Fourier transformation. RESULTS: Nineteen panic disorder patients resistant to pharmacological treatment entered a 6-week open-label treatment study with combination of SSRI and CBT. The combination of CBT and pharmacotherapy proved to be an effective treatment in these patients. The patients significantly improved during the study period in all rating scales. There were highly statistical significant differences between panic patients and control group in all components of power spectral analysis in 2nd (VLF, LF and H in standing) and in two component of 3rd (LF and HF in supine) positions. There was also a statistically significant difference between these two groups in LF/HF ratio in standing position (2nd). During therapy there was a tendency increasing values in all three positions in components of HRV power spectra, but HF in 1st supine position was the only component where the increase reached the level os statistical significance. CONCLUSIONS: These findings demonstrate a lower autonomic activity in panic disorder patients measured during the changes of postural position in comparison with healthy controls and tendency to increase this autonomic power during the treatment.

• MeSH
• antidepresiva terapeutické užití   MeSH
• autonomní nervový systém účinky léků   patofyziologie   MeSH
• benzodiazepiny terapeutické užití   MeSH
• disociační poruchy komplikace   farmakoterapie   patofyziologie   MeSH
• dospělí MeSH
• elektrokardiografie MeSH
• kognitivně behaviorální terapie MeSH
• kombinovaná terapie MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• panická porucha komplikace   farmakoterapie   patofyziologie   MeSH
• postura těla fyziologie   MeSH
• srdeční frekvence účinky léků   fyziologie   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky kontrolované MeSH
• práce podpořená grantem MeSH

• MeSH
• autonomní nervový systém patofyziologie   MeSH
• bipolární porucha * patofyziologie   MeSH
• klinická studie jako téma MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH

BACKGROUND: Autonomic nervous system (ANS) dysfunction and reduced heart rate variability (HRV) have been reported in a wide variety of psychiatric disorders, but have not been well characterized in bipolar patients in remission. We recorded cardiac activity and assessed HRV in bipolar outpatients in remission. AIMS: Ascertain if ANS decrease with the age of the patient; ascertain relation between activity of ANS and level of dissociation, and other components (age of patients, and age of disorder, dosage of psychotropic medication) METHODS: Autonomic nervous system (ANS) has been evaluated during orthostatic change in three positions (1 - lie down 5 minutes, 2 - stand up 5 minutes, 3 - lie down 5 minutes). The functioning of the ANS has been measured by the diagnostic systems that are using the power spectral analysis which quantifies the heart rate variability (HRV) was assessed using time domain, frequency domain, and nonlinear analyses in 23 bipolar patients in remission. RESULTS: We found highly statistically significant negative correlations between level of dissociation measured by DES (Dissociative Experience Scale) and most of parameters of ANS. We found negative correlations between the age of the patient and activity of ANS, and negative correlations between activity of ANS and duration and onset of disorder. CONCLUSIONS: Autonomic dysregulation is associated with bipolar disorder in remission and has relation to level of dissociation and probably to age of patients and age of onset and duration of disorder.

• MeSH
• afekt účinky léků   MeSH
• antidepresiva terapeutické užití   MeSH
• antipsychotika terapeutické užití   MeSH
• autonomní nervový systém patofyziologie   MeSH
• bipolární porucha diagnóza   farmakoterapie   patofyziologie   MeSH
• dospělí MeSH
• indukce remise MeSH
• lidé středního věku MeSH
• lidé MeSH
• pacienti ambulantní MeSH
• srdeční frekvence MeSH
• věk při počátku nemoci MeSH
• věkové faktory MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• Klíčová slova
• autonomní dysfunkce, riziko náhlé srdeční smrti, elektrická nestabilita srdce, fyzická zátěž, pokles vagové modulace srdeční frekvence, spektrální analýza variability srdeční frekvence, preskripce pohybové aktivity,
• MeSH
• algoritmy MeSH
• autonomní nervový systém MeSH
• dospělí MeSH
• kardiovaskulární nemoci MeSH
• lidé středního věku MeSH
• lidé MeSH
• náhlá srdeční smrt MeSH
• nervus vagus MeSH
• riziko MeSH
• spektrální analýza MeSH
• statistika jako téma MeSH
• tělesná námaha MeSH
• zátěžový test MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

• Klíčová slova
• nordická chůze, energetický výdej, měření axiálních sil v holích,
• MeSH
• chůze (způsob) MeSH
• energetický metabolismus MeSH
• financování organizované MeSH
• lidé MeSH
• nordic walking MeSH
• výzkum MeSH
• Check Tag
• lidé MeSH

Aims: The accuracy of non-radiographic measurement of the spinal shape is infl uenced by postural sway (PS).The aim of this study was to determine whether certain examination postures prevent PS without changing key spinalcharacteristics. Methods: We tested 1) natural standing position (posture A), 2) fi xation postures standing with the support of theupper limbs against a wall (posture B) and 3) standing with the support of the head and chest against a wall (postureC). There were examined 60 subjects; the examination of each posture was repeated fi ve times in each individual byDTP-3 microcomputer position system. The spinal shape changes resulting from tested postures were assessed usingt-test. The role of PS was assessed using standard deviations, and the signifi cance of diff erences between the individualpostures was determined using the F-test. Results: Compared to posture A, the fi xation posture B did not have any signifi cant infl uence on the degree of PS,but it signifi cantly infl uenced the shift of the spine from the ideal vertical and its slope, although this did not result inspine curve deformation. The fi xation posture C signifi cantly reduced the PS compared to posture A; however, therewere signifi cant changes in the spinal shape. This fi xation posture shifted signifi cantly the spine from the ideal verticaland slope characteristics.Conclusion: PS plays a role in the examination of spinal shape. Positions B and C did not meet the required criteria.Therefore, it is necessary to search for another examination position.

• MeSH
• diagnostické techniky a postupy využití   MeSH
• experimenty na lidech MeSH
• financování organizované MeSH
• lidé MeSH
• mikropočítače využití   MeSH
• muskuloskeletální systém - fyziologické jevy MeSH
• postura těla fyziologie   MeSH
• posturální rovnováha MeSH
• statistika jako téma MeSH
• zakřivení páteře diagnóza   etiologie   MeSH
• zobrazování trojrozměrné metody   přístrojové vybavení   využití   MeSH
• Check Tag
• lidé MeSH

• Publikační typ
• abstrakty MeSH