The purpose of this study was to determine the relation between posturally increased intra-abdominal pressure and lower/upper esophageal sphincter pressure changes in patients with gastroesophageal reflux disease. We used high resolution manometry to measure pressure changes in lower and upper esophageal sphincter during bilateral leg rise. We also examined whether the rate of lower and upper esophageal sphincter pressure would increase during leg raise differentially in individuals with versus without normal resting pressure. Fifty eight patients with gastroesophageal reflux disease participated in the study. High resolution manometry was performed in relaxed supine position, then lower and upper esophageal sphincter pressure was measured. Finally, the subjects were instructed to keep their legs lifted while performing 90-degree flexion at the hips and knees and the pressure was measured again. Paired t-test and independent samples t-test were used. There was a significant increase in both lower (P < 0.001) and upper esophageal sphincter pressure (P = 0.034) during leg raise compared to the initial resting position. Individuals with initially higher pressure in lower esophageal sphincter (>10 mmHg) exhibited a greater pressure increase during leg raise than those with initially lower pressure (pressure ≤10 mmHg; P = 0.002). Similarly individuals with higher resting upper esophageal sphincter pressure (>44 mmHg) showed a greater pressure increase during leg raise than those with lower resting pressure (≤44 mmHg; P < 0.001). The results illustrate the influence of postural leg activities on intraesophageal pressure in patients with gastroesophageal reflux disease, indicating by means of high resolution manometry that diaphragmatic postural and sphincter function are likely interrelated in this population.
- MeSH
- bérec fyziologie MeSH
- dolní jícnový svěrač fyziologie MeSH
- dospělí MeSH
- gastroezofageální reflux patofyziologie MeSH
- horní jícnový svěrač fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- manometrie MeSH
- postura těla MeSH
- senioři MeSH
- svalová kontrakce fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- hypochromní anemie diagnóza etiologie MeSH
- ileus etiologie MeSH
- lidé MeSH
- nádory břicha diagnóza chirurgie MeSH
- nádory slinivky břišní diagnóza chirurgie MeSH
- pankreatitida MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- kongresy MeSH
- MeSH
- gastrointestinální krvácení diagnóza etiologie komplikace MeSH
- lidé MeSH
- poranění břicha komplikace MeSH
- střevní lymfangiektázie diagnóza etiologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- kongresy MeSH
