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OBJECTIVE: To evaluate the amount of macronutrients in aggregate of human milk samples after preterm delivery during the first 2 months of lactation. METHODS: Analysis of the donated single milk samples, gained by complete emptying of the whole breast at the same daytime between 24+0 and 35+6 gestational age (GA), was designed as prospective observational cohort trial. Two milk samples were analysed every postnatal week up to the discharge from the hospital, week 9 or loss of lactation. 24-Hour milk collection was not done. Analysis was performed using the MIRIS Human Milk Analyser (MIRIS AB, Uppsala, Sweden). RESULTS: A set of 1917 human milk samples donated by 225 mothers after preterm labour was analysed. Group A (24-30 GA) contains 969 milk samples; group B (31-35 GA) contains 948 milk samples. No difference in milk composition between the groups was identified. Median of true protein content decreased from 1.6 g/dL in group A and 1.5 g/dL in group B in the first week of life, to 1.1 g/dL in both groups at the end of week 3, and then remained stable up to week 9. Content of carbohydrates and fat was stable during the whole observation, with interindividual differences. CONCLUSION: Human milk does not differ as a function of degree of prematurity. Protein content of preterm human milk is low and decreases during the first 3 weeks of lactation. Recommended daily protein intake cannot be achieved with routine fortification in majority of milk samples.

Článek online

Změny obsahu bílkoviny v mateřském mléce po předčasném porodu

Neonatologické listy. 2018 ; 24 (1) : 3-6.

ISSN 1211-1600
Medvik
Zdroj

Článek online

Změny obsahu bílkoviny v mateřském mléce po předčasném porodu
[Protein concentration in human milk after preterm delivery]

Československá pediatrie. 2017 ; 72 (8) : 472-477.

ISSN 0069-2328
Medvik
Zdroj

Cíl studie: Stanovit obsah bílkoviny v mateřském mléce v prvních 2 měsících po předčasném porodu metodou infračervené spektroskopie a porovnat rozdíly vzhledem k míře nedonošenosti. Metodika: Vzorky mateřského mléka byly analyzovány 2x týdně u matek, které porodily mezi 24+0 a 35+6 gestačním týdnem (GT). Sběr a analýza se ukončovala po 9. týdnu po porodu, při nedostatečné laktaci dříve. Analýza vzorku byla provedena metodou infračervené spektroskopie (přístroj MIRIS AB, Uppsala, Švédsko). Výsledky: V souboru 225 matek bylo analyzováno 1917 vzorků mléka. Skupina A (24.–30. GT) obsahovala 969 vzorků, skupina B (31.–35. GT) 948 vzorků. Koncentrace bílkoviny klesla u skupiny A z hodnoty 1,72 (1,0–5,0) g/100 ml (medián, mezikvartilové rozpětí IQR), u skupiny B z hodnoty 1,65 (1,1–3,6) g/100 ml (medián, IQR) na konci 1. týdne po porodu na průměrnou koncentraci 1,1 (0,9–1,2) g/100 ml (medián, IQR) u obou skupin na konci 3. týdne. Dále byla koncentrace bílkoviny u obou skupin stabilní do konce 9. týdne (průměrná hodnota 1,0 g/100 ml). Mezi skupinami A a B nebyl po celou dobu sledování zjištěn signifikantní rozdíl v koncentraci bílkoviny. Závěr: Obsah bílkoviny v mateřském mléce matek, které porodily předčasně, není ovlivněn stupněm nezralosti. Koncentrace bílkoviny klesá v prvních 3 týdnech po porodu. Nízká koncentrace bílkoviny v mateřském mléce i při plné fortifikaci nesplňuje výživové požadavky pro nedonošené novorozence s velmi nízkou porodní hmotností.

Aim of study: To evaluate the amount of protein in a set of human milk samples using mid-infrared human milk analyser after preterm labour during the first two months of lactation. Methods: Analysis of the donated milk samples between 24+0 and 35+6 gestational age (GA) was designed as prospective observational cohort trial. Two milk samples were analysed up to the discharge from the hospital, week 9 or loss of lactation. Analysis was performed using the MIRIS Human Milk Analyser (MIRIS AB, Uppsala, Sweden). Results: Total of 1917 human milk samples donated by 225 mothers after preterm labour were analysed. Group A (24–30 GA) contained 969 milk samples, the group B (31–35 GA) contained 948 milk samples. Mean true protein content decreased from 1.72 g/dL in group A and 1.65 g/dL in group B at the end of the first week of life to 1.1 g/dL in both groups at the end of the week 3, and remained stable with mean values around 1.0 g/dL up to week 9. Conclusion: There was no difference in the protein content of human milk as a function of term of premature delivery. Moreover the protein content was lower than expected and even decreased during first three weeks of lactation. We did not detect a significant difference in milk protein levels between group A (24–30 GA) and group B (31–35 GA).