A multi-residue UHPLC-MS/MS analytical method, previously developed for monitoring 52 pharmaceuticals in drinking water, was used to analyse these pharmaceuticals in wastewater originating from healthcare facilities in the Czech Republic. Furthermore, the methodology was expanded to include the evaluation of the effectiveness of drug removal in Czech wastewater treatment plants (WWTPs). Of the 18 wastewater samples analysed by the validated UHPLC-MS/MS, each sample contained at least one quantifiable analyte. This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L-1 of iomeprol, 48.8 μg L-1 of iopromide, 29.9 μg L-1 of gabapentin, 42.0 μg L-1 of caffeine and 82.5 μg L-1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed high removal efficiencies exceeding 80%. On the other hand, pharmaceuticals like furosemide, metoprolol, iomeprol, zolpidem and tramadol showed lower removal efficiencies. Four pharmaceuticals exhibited higher concentrations in WWTP effluents than in the influents, resulting in negative removal efficiencies: warfarin at -9.5%, indomethacin at -53%, trimethoprim at -54% and metronidazole at -110%. These comprehensive findings contribute valuable insights to the pharmaceutical landscape of wastewater from healthcare facilities and the varied removal efficiencies of Czech WWTPs, which together with the already published literature, gives a more complete picture of the burden on the aquatic environment.
OBJECTIVES: The objective of this study was to assess the robustness of a novel test bolus (TB)-based computed tomographic angiography (CTA) contrast-enhancement-prediction (CEP) algorithm by retrospectively quantifying the systematic and random errors between the predicted and true enhancements. MATERIALS AND METHODS: All local institutional review boards approved this retrospective study, in which a total of 72 (3 × 24) anonymized cardiac CTA examinations were collected from 3 hospitals. All patients (46 men; median age, 62 years [range, 31-81 years]) underwent a TB scan and a cardiac CTA according to local scan and injection protocols. For each patient, a shorter TB signal and TB signals with lower temporal resolution were derived from the original TB signal. The CEP algorithm predicted the enhancement in the descending aorta (DAo) on the basis of the TB signals in the DAo, the injection protocols and kilovolt settings, as well as population-averaged blood circulation characteristics. The true enhancement was extracted with a region of interest along the DAo centerline. For each patient, the errors in timing and amplitude were calculated; differences between the hospitals were assessed using the 1-way analysis of variance (P < 0.05) and variations between the TB signals were assessed using the within-subject standard deviation. RESULTS: No significant differences were found between the 3 hospitals for any of the TB signals. With errors in the amplitude and timing of 0.3% ± 15.6% and -0.2 ± 2.0 seconds, respectively, no clinically relevant systematic errors existed. Shorter- and coarser-time-sampled TB signals introduced a within-subject standard deviation of 4.0% and 0.5 seconds, respectively. CONCLUSIONS: This TB-based CEP algorithm has no systematic errors in the timing and amplitude of predicted enhancements and is robust against coarser-time-sampled and incomplete TB scans.
- MeSH
- algoritmy * MeSH
- dospělí MeSH
- jopamidol analogy a deriváty diagnostické užití MeSH
- kontrastní látky diagnostické užití MeSH
- koronární angiografie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen radiografie MeSH
- počítačová rentgenová tomografie metody MeSH
- počítačové zpracování obrazu metody MeSH
- prediktivní hodnota testů MeSH
- reprodukovatelnost výsledků MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vylepšení rentgenového snímku metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- MeSH
- amoxicilin MeSH
- antibakteriální látky škodlivé účinky MeSH
- antidepresiva MeSH
- antiflogistika nesteroidní MeSH
- antifungální látky škodlivé účinky MeSH
- antihypertenziva MeSH
- antikoagulancia škodlivé účinky MeSH
- fixní kombinace léků MeSH
- gadolinium MeSH
- imunosupresiva škodlivé účinky MeSH
- inhibitory TNF MeSH
- jopamidol škodlivé účinky MeSH
- klarithromycin MeSH
- kontrastní látky MeSH
- kožní manifestace MeSH
- léčivé přípravky * MeSH
- lidé MeSH
- nežádoucí účinky léčiv MeSH
- příznaky a symptomy MeSH
- statiny škodlivé účinky MeSH
- systémy pro sběr zpráv o nežádoucích účincích léků MeSH
- tumor nekrotizující faktory MeSH
- Check Tag
- lidé MeSH
OBJECTIVE: To compare the incidence of seizures in dogs with intervertebral disk disease after iopamidol or iomeprol myelography, and to assess whether the incidence of seizures differed between the 2 agents when severity of neurological deficits, location of cord compression, duration of anesthesia, site of myelogram, volume of contrast, and concentration of contrast were evaluated. DESIGN: Retrospective study. SETTING: Veterinary teaching hospital. ANIMALS: One hundred and sixty-one client-owned dogs with intervertebral disk disease. INTERVENTIONS: Subarachnoid injection of contrast medium. MEASUREMENTS AND MAIN RESULTS: One hundred and sixty-one dogs with intervertebral disk disease were subjected to myelography using iopamidol (n=74) or iomeprol (n=87). Cranial myelography was performed in 31 dogs, caudal myelography in 125 and both cranial and caudal myelography in 5. Seizures occurred in 23 of 161 (14%) dogs. There was no significant difference overall between iopamidol and iomeprol myelography. However, in dogs with thoracolumbar disk extrusion and paraplegia, seizures occurred more frequently after caudal myelography using iopamidol compared with iomeprol. CONCLUSIONS: Both iomeprol and iopamidol are suitable for myelography in dogs. Iomeprol is recommended for caudal myelography in paraplegic dogs with thoracolumbar disk extrusion due to the higher incidence of seizures in this group when iopamidol was used.
- MeSH
- bederní obratle radiografie MeSH
- jopamidol škodlivé účinky analogy a deriváty MeSH
- kontrastní látky škodlivé účinky MeSH
- krční obratle radiografie MeSH
- multivariační analýza MeSH
- myelografie škodlivé účinky veterinární MeSH
- nemoci psů chemicky indukované epidemiologie MeSH
- paraplegie radiografie MeSH
- psi MeSH
- retrospektivní studie MeSH
- školy veterinární MeSH
- výhřez meziobratlové ploténky radiografie veterinární MeSH
- záchvaty chemicky indukované epidemiologie veterinární MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Pneumatosis cystoides coli (PCC) je vzácné idiopatické onemocnění charakterizované výskytem mnohočetných plynem vyplněných cyst ve střevní stěně v submukóze či subseróze. Postižena může být kterákoliv část tračníku, nejčastěji je postižena jeho levá polovina. Díky spolupráci více pracovišť je prezentován soubor tří pacientů s náhodným záchytem PCC při kolonoskopii, u nichž byla diagnóza následně verifikována pomocí CT virtuální kolonoskopie.
Pneumatosis cystoides coli (PCC) is rare idiopathic disorder characterized by many cysts filled with air located in the colon wall in submucose or subserose layer. Any part of the colon can be affected, but the most affected region is it's left side. Thanks to cooperation among departments we can present three cases with accidental finding PCC during colonoscopy The diagnose was verified by virtual CT colonoscopy.
- MeSH
- butylskopolamin aplikace a dávkování MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- jopamidol analogy a deriváty diagnostické užití MeSH
- kolonografie počítačovou tomografií metody využití MeSH
- kolonoskopie metody trendy využití MeSH
- lidé MeSH
- pneumatosis cystoides intestinalis diagnóza etiologie chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
