- MeSH
- atrazin toxicita MeSH
- imunitní systém účinky léků MeSH
- imunotoxiny MeSH
- myši inbrední A MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
We examined the effect of soluble derivatives of yeast glucan on the humoral immune response of various strains of inbred mice after administration of different doses according to various schedules. Glucan was injected i.v. or s.c. in a single dose or repeatedly. The immune response was examined by determining the titres of serum hemagglutinins against sheep erythrocytes (SRBC-Ab). The immunoadjuvant effect of glucan derivatives depends on the inbred strain used, on the dose of glucan, mode and time of administration with respect to antigen injection. The results have shown that the stimulatory effect of glucan derivatives occurred already after a single injection, the optimum dose being 10-20 mg/kg. Intravenous injection was more efficient than the subcutaneous one. In some cases, a slight increase of the spleen mass was observed.
- MeSH
- adjuvancia imunologická aplikace a dávkování farmakologie MeSH
- druhová specificita MeSH
- glukany aplikace a dávkování imunologie farmakologie MeSH
- hemaglutininy biosyntéza MeSH
- imunologická odpověď na dávku MeSH
- kvasinky chemie imunologie MeSH
- myši inbrední A MeSH
- myši inbrední C57BL MeSH
- myši inbrední CBA MeSH
- myši MeSH
- ovce MeSH
- tvorba protilátek MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
We examined the effects of 5 soluble derivatives of yeast glucan on the formation of exogenous (CFU-S) and endogenous (E-CFU) colony-forming units in the spleens of sublethally irradiated (60Co, 6.5-7.0 Gy) mice of two inbred strains. For the estimation of CFU-S, glucans were administered intravenously either to donors or recipients of spleen cells 24 h prior to irradiation or removal of the spleen. The number of CFU-S was increased when both the donors and recipients were treated with glucan; the highest increase was obtained with glucans S, P and K. All glucan preparations increased significantly also the number of E-CFU even when administered 90 min after irradiation. There exist differences in the response to the stimulatory effect of glucans among individual mouse strains. Thus, for example, the stimulatory effect of glucan KM on the E-CFU number was significantly more pronounced in strain A/Ph than in strain C57Bl/6.
- MeSH
- analýza kolonii tvořících jednotek MeSH
- glukany farmakologie MeSH
- hematopoetické kmenové buňky účinky léků MeSH
- myši inbrední A MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- Saccharomyces cerevisiae * MeSH
- slezina cytologie účinky léků účinky záření MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- autoradiografie metody využití MeSH
- erytrocyty imunologie účinky léků MeSH
- experimenty na zvířatech MeSH
- fluorouracil * aplikace a dávkování diagnostické užití MeSH
- imunizace * metody využití MeSH
- myši inbrední A MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- proliferace buněk * účinky léků MeSH
- slezina cytologie účinky léků MeSH
- statistika jako téma MeSH
- thymidin aplikace a dávkování MeSH
- způsoby aplikace léků MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
