Addis, A*
Dotaz
Zobrazit nápovědu
Background: The incidence of low birth weight is estimated to be 16% worldwide, 19% in developing countries, and 7% in developed countries. Currently, 13% of Ethiopian babies are born with a low weight; different studies have reported that the prevalence of low birth weight accounts for about 8.8% in Addis Ababa and 10.5% in the Tigray region. This study is primarily aimed at assessing the factors associated with the low birth weight of newborns in selected Addis Ababa public hospitals. Methods: Data collection was conducted in Addis Ababa from March 2021 to April 2021. A facility-based cross-sectional study was used among 466 mothers who gave birth in public hospitals during a reference period. Primary data were collected using a structured questionnaire adopted from previous studies. The sample size was calculated by Epi Info calc using an assumption of 95% CI, 80% power, 20.6 percent exposed, 10.4 percent unexposed, and 2.2 Adjusted Odds Ratio (AOR). Univariate, bivariate, and multiple logistic regression analyses were used. Adjusted odds ratios were used to identify the association between the key predictors and the dependent variable (birth weight). Results: Of the total respondents, 12.4% gave birth to infants with a low birth weight. The median age of the participants was 28 yrs (IQR = 7). The results of multivariable logistic regression showed that the key determinants of low birth weight among the study population were: number of ANC (Antenatal Care) visits (AOR = 0.4, 95% CI: 0.17–0.99), presence of Abnormal Uterine Bleeding (AUB) during recent pregnancy (AOR = 10.9, 95% CI: 2.5–15.8), having pre-eclampsia or eclampsia during recent pregnancy (AOR 9.5, 95% CI: 4.8–10.8), Anemia during pregnancy (AOR = 3.3, 95% CI 3.1–3.6), Chewing Kchat (AOR = 7.9, 95% CI: 3.9–16.1), and pre-pregnancy maternal nutritional (AOR = 0.2, 95% CI: 0.1–0.5). Conclusions: Encouraging pregnant mothers to make frequent ANC visits, behavioral change communications that target pregnant women for improving women’s nutritional status, and reducing maternal toxic exposures should be priority areas of interventions to curb the problem.
The gills of 63 specimens of the Atlantic bluefin tuna Thunnus thynnus (Linnaeus) (Osteichthyes: Scombridae) from three localities of the Mediterranean (Sardinian, Tyrrhenian and Levantine Seas) were examined for metazoan parasites. The parasite fauna of T. thynnus from the Sea of Sardinia included 11 species: five didymozoid trematodes, three capsalid and one hexostomid monogeneans, and one caligid and one pseudocycnid copepods. Four didymozoids were found in fish from the Levantine Sea and only one didymozoid was recorded in fish from the Tyrrhenian Sea. Dividing the hosts into four size-groups (small, medium-sized, large and extra large), the pairwise comparison of prevalence and mean abundance of the new and literary data) showed differences according to host size. The differences in the composition of the parasitic faunas and in the prevalence of parasites, observed between the small tunas from the Tyrrhenian Sea and the medium-sized tunas from the Adriatic Sea, Levantine Sea and the North-East (NE) Atlantic Ocean, indicated that these groups form discrete units. The parasite fauna of the large tunas from the Sea of Sardinia is the richest among the bluefin tuna populations of the Mediterranean and the NE Atlantic, due to the presence of species not found elsewhere in bluefin tunas, such as Caligus coryphaenae Steenstrup et Lütken, 1861, Capsala magronum (Ishii, 1936) and C. paucispinosa (Mamaev, 1968). This fact and the prevalence of some parasites of this group (lower than those of medium-sized fish from the NE Atlantic and higher than the small and medium-sized tunas from the Mediterranean) suggest that the large-sized tuna group in the western Mediterranean is formed by Mediterranean resident tunas (poorly infected), and by tunas migrating from the Atlantic Ocean (heavily infected).
- MeSH
- Copepoda klasifikace MeSH
- infekce červy třídy Trematoda epidemiologie parazitologie veterinární MeSH
- parazitární nemoci u zvířat epidemiologie parazitologie MeSH
- Trematoda klasifikace izolace a purifikace MeSH
- tuňák * MeSH
- žábry parazitologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Středozemní moře MeSH
- MeSH
- kostra účinky záření MeSH
- myši MeSH
- plutonium metabolismus MeSH
- radionuklidy metabolismus MeSH
- Check Tag
- myši MeSH
- Publikační typ
- srovnávací studie MeSH
BACKGROUND: Biologics have greatly improved psoriasis management. However, primary and secondary non-response to treatment requires innovative strategies to optimize outcomes. OBJECTIVE: To describe the use of combined treatment of biologics with conventional systemic agents or phototherapy in daily clinical practice. METHODS: We collected data on frequency of use, demographics, treatment characteristics and drug survival of biologics combined with conventional systemic agents or phototherapy in five PSONET registries. RESULTS: Of 9922 biologic treatment cycles, 982 (9.9%) were identified as combination treatment. 72.9% of treatment cycles concerned concomitant use of methotrexate, 25.3% concerned concomitant UVB therapy, acitretin or cyclosporin and 1.8% concerned combined treatment with PUVA, fumaric acids or a second biologic. Substantial variation was detected in type and frequency of combination treatments prescribed across registries. Patients initiated on combined treatment had generally severe disease and were affected with psoriasis for many years. The extent to which patients had been priory treated with biologic monotherapy and the proportion of patients affected with psoriatic arthritis differed between registries. Survival rates for etanercept, adalimumab, infliximab and ustekinumab with methotrexate ranged between 43 and 92%, 28 and 83%, 65 and 87% and 53 and 77%, respectively, across registries after one year with no consistent superior survival for a particular biologic. Longest survival on a biologic combined with methotrexate, acitretin or cyclosporin was 103, 78 and 34 months, respectively. CONCLUSION: Methotrexate was the most commonly used concomitant treatment for patients on a biologic. Wide geographical variations in treatment selection and persistence of combination treatment exist. Data derived from ongoing studies may help to determine whether combined treatment is superior to biologic monotherapy.
- MeSH
- acitretin terapeutické užití MeSH
- adalimumab terapeutické užití MeSH
- biologické přípravky terapeutické užití MeSH
- cyklosporin terapeutické užití MeSH
- dermatologické látky terapeutické užití MeSH
- etanercept terapeutické užití MeSH
- fumaráty terapeutické užití MeSH
- infliximab terapeutické užití MeSH
- Kaplanův-Meierův odhad MeSH
- kombinovaná farmakoterapie MeSH
- kombinovaná terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- methotrexát terapeutické užití MeSH
- psoriáza terapie MeSH
- PUVA terapie * MeSH
- registrace MeSH
- stupeň závažnosti nemoci MeSH
- ustekinumab terapeutické užití MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Itálie MeSH
- Izrael MeSH
- Nizozemsko MeSH
- Rakousko MeSH
11, 628 s. : il.
OBJECTIVES: Autoinflammatory diseases cause systemic inflammation that can result in damage to multiple organs. A validated instrument is essential to quantify damage in individual patients and to compare disease outcomes in clinical studies. Currently, there is no such tool. Our objective was to develop a common autoinflammatory disease damage index (ADDI) for familial Mediterranean fever, cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic fever syndrome and mevalonate kinase deficiency. METHODS: We developed the ADDI by consensus building. The top 40 enrollers of patients in the Eurofever Registry and 9 experts from the Americas participated in multiple rounds of online surveys to select items and definitions. Further, 22 (parents of) patients rated damage items and suggested new items. A consensus meeting was held to refine the items and definitions, which were then formally weighted in a scoring system derived using decision-making software, known as 1000minds. RESULTS: More than 80% of the experts and patients completed the online surveys. The preliminary ADDI contains 18 items, categorised in the following eight organ systems: reproductive, renal/amyloidosis, developmental, serosal, neurological, ears, ocular and musculoskeletal damage. The categories renal/amyloidosis and neurological damage were assigned the highest number of points, serosal damage the lowest number of points. The involvement of (parents of) patients resulted in the inclusion of, for example, chronic musculoskeletal pain. CONCLUSIONS: An instrument to measure damage caused by autoinflammatory diseases is developed based on consensus building. Patients fulfilled a significant role in this process.
- MeSH
- dědičné zánětlivé autoimunitní nemoci komplikace MeSH
- dítě MeSH
- dospělí MeSH
- horečka komplikace MeSH
- konsensus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- přehledová literatura jako téma MeSH
- průzkumy a dotazníky MeSH
- senioři MeSH
- stupeň závažnosti nemoci * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- předškolní dítě MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- konsensus - konference MeSH
