• MeSH
• extrakce zubů MeSH
• implantace zubů klasifikace   metody   MeSH
• stomatochirurgické výkony MeSH
• zubní implantáty jednotlivých zubů MeSH
• zubní implantáty MeSH

• Konspekt
• Stomatologie
• NLK Obory
• zubní lékařství
• NLK Publikační typ
• kolektivní monografie

• Konspekt
• Biochemie. Molekulární biologie. Biofyzika
• NLK Obory
• environmentální vědy
• biochemie

• MeSH
• dospělí MeSH
• infarkt myokardu MeSH
• koronární nemoc MeSH
• lidé MeSH
• multivariační analýza MeSH
• rizikové faktory MeSH
• rodinní lékaři MeSH
• zdraví rodiny MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• srovnávací studie MeSH
• Geografické názvy
• Taiwan MeSH

Arbuscular mycorrhizal fungi (AMF) are ubiquitous mutualists of terrestrial plants and play key roles in regulating various ecosystem processes, but little is known about AMF biogeography at regional scale. This study aims at exploring the key predictors of AMF communities across a 5000-km transect in northern China. We determined the soil AMF species richness and community composition at 47 sites representative of four vegetation types (meadow steppe, typical steppe, desert steppe and desert) and related them to plant community characteristics, abiotic factors and geographic distance. The results showed that soil pH was the strongest predictor of AMF richness and phylogenetic diversity. However, abiotic factors only have a low predictive effect on AMF community composition or phylogenetic patterns. By contrast, we found a significant relationship between community composition of AMF and plants, which was a surprising result given the extent of heterogeneity in the plant community across this transect. Moreover, the geographic distance predominantly explained the AMF phylogenetic structure, implying that history evolutionary may play a role in shaping AMF biogeographic patterns. This study highlighted the different roles of main factors in predicting AMF biogeography, and bridge landscape-scale studies to more recent global-scale efforts.

• MeSH
• fylogeografie * MeSH
• hostitelská specificita MeSH
• koncentrace vodíkových iontů MeSH
• mykorhiza klasifikace   genetika   izolace a purifikace   MeSH
• půda chemie   MeSH
• rostliny mikrobiologie   MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Čína MeSH

Osteoporosis is a bone disease characterized by low bone mineral density (BMD) and impaired bone microarchitecture due to the abnormal activity of osteoclasts. Cathelicidins are antimicrobial peptides present in the lysosomes of macrophages and polymorphonuclear leukocytes. LL-37, a cathelicidin, induces various biological effects, including modulation of the immune system, angiogenesis, wound healing, cancer growth, as well as inflammation, and bone loss. A previous study reported direct involvement of LL-37 suppressing osteoclastogenesis in humans. Here, we examined the role of LL-37 in the treatment of osteoporosis using an ovariectomy (OVX) rat model. Our results showed that LL-37 significantly reduced bone loss and pathological injury in OVX rats with osteoporosis. Furthermore, we found that LL-37 significantly increased the activity of the Wnt/beta-catenin pathway in OVX rats with osteoporosis, including the increased expression of beta-catenin, Osterix (Osx), and Runt-related transcription factor 2 (Runx2), whereas XAV-939, an inhibitor of the Wnt/beta-catenin pathway, significantly blocked the effects of LL-37 on bone loss and abnormal bone metabolism. Altogether, our findings suggested that LL-37 exerted a protective role in regulating bone loss and abnormal bone metabolism in rats with osteoporosis by activating the Wnt/beta-catenin pathway.

• MeSH
• beta-katenin metabolismus   MeSH
• buněčná diferenciace MeSH
• kationické antimikrobiální peptidy * farmakologie   MeSH
• kostní denzita * MeSH
• krysa rodu rattus MeSH
• osteogeneze MeSH
• osteoporóza * farmakoterapie   etiologie   prevence a kontrola   MeSH
• ovarektomie MeSH
• signální dráha Wnt * MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Grey mold, caused by Botrytis cinerea, is a widespread and harmful disease of tomato. Biocontrol agents derived from endophytic bacteria are known to hold great potential for inhibition of phytopathogen. We conducted this study to explore the tomato endophytic strains with inhibition activity against B. cinerea. Endophytic strain Bacillus velezensis FQ-G3 exhibited excellent inhibition activity against B. cinerea. Inhibitory effects against B. cinerea were investigated both in vitro and in vivo. The in vitro assays displayed that FQ-G3 could significantly inhibit mycelia growth with inhibition rate of 85.93%, and delay conidia germination of B. cinerea. Tomato fruit inoculated with B. velezensis FQ-G3 revealed lower grey mold during treatment. The antifungal activity was attributed to activation of defense-related enzymes, as evidenced by the higher levels of peroxidase, polyphenol oxidase, and phenylalanine ammonia lyase in tomatoes after inoculation. In addition, scanning electron microscope was applied to elucidate the interaction between endophytes and pathogen, and bacterial colonization and antibiosis appeared to be the underlying mechanisms that FQ-G3 could suppress growth of B. cinerea. Collectively, our present results suggested that FQ-G3 may potentially be useful as a biocontrol agent in postharvest tomatoes.

• MeSH
• Bacillus * MeSH
• Botrytis * MeSH
• endofyty MeSH
• nemoci rostlin prevence a kontrola   mikrobiologie   MeSH
• Solanum lycopersicum * MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence trends for MPM remain poorly characterized. We use nationwide MPM data for Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) to assess incidence, mortality and survival trends for MPM in these countries. METHODS: We use the NORDCAN database for the analyses: incidence data were available from 1943 in DK, 1953 in FI and NO and 1958 in SE, through 2016. Survival data were available from 1967 through 2016. World standard population was used in age standardization. RESULTS: The lowest incidence that we recorded for MPM was 0.02/100,000 for NO women and 0.05/100,000 for FI men in 1953-57, marking the incidence before the influence of asbestos. The highest rate of 1.9/100,000 was recorded for DK in 1997. Female incidence was much lower than male incidence. In each country, the male incidence trend for MPM culminated, first in SE around 1990. The regional incidence trends matched with earlier asbestos-related industrial activity, shipbuilding in FI and SE, cement manufacturing and shipbuilding in DK and seafaring in NO. Relative 1-year survival increased from about 20 to 50% but 5-year survival remained at or below 10%. CONCLUSION: In the Nordic countries, the male incidence trends for MPM climaxed and started to decrease, indicating that the prevention of exposure was beneficial. Survival in MPM has improved for both sexes but long-term survival remains dismal.

• MeSH
• analýza přežití MeSH
• azbest škodlivé účinky   normy   MeSH
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• dospělí MeSH
• incidence MeSH
• lidé středního věku MeSH
• lidé MeSH
• maligní mezoteliom epidemiologie   etiologie   MeSH
• mladý dospělý MeSH
• mortalita dějiny   trendy   MeSH
• nádory pleury epidemiologie   etiologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sexuální faktory MeSH
• věkové rozložení MeSH
• vystavení vlivu životního prostředí škodlivé účinky   normy   MeSH
• Check Tag
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• historické články MeSH
• Geografické názvy
• Dánsko MeSH
• Finsko MeSH
• Norsko MeSH
• Švédsko MeSH

The large amounts of ammonia emissions generated from industrial production have caused serious environmental pollution problems, such as soil acidification, eutrophication, the formation of fine particles and changes in the global greenhouse balance, and also greatly endanger human health. At present, effectively reducing ammonia emissions or recovering ammonia is still a huge challenge. Ionic liquids (ILs) as a new class of green solvent have been introduced for ammonia absorption with great potential, but a huge number on combination systems of ILs lead to the difficulty of measuring the ammonia solubility in all ILs by experiments (e.g., danger and cost). Hereby, this study proposed a novel approach for estimating the ammonia solubility in different ILs. A predictive model was developed based on the novel Algorithm - extreme learning machine (ELM) and the molecular descriptors of electrostatic potential surface areas (SEP) as input parameters. Besides, 502 data points of ammonia solubility in 17 ILs were gathered with a wide range of pressure and temperature. For the total set, the determination coefficient (R2) and the average absolute relative deviation (AARD) of the developed model were 0.9937 and 2.95%, respectively. The regression plots revealed good consistency between predictive and experimental data points. Results show the good performance and reliability of the developed model, indicating that the proposed approach can be potentially applied for screening reasonable ILs to absorb ammonia from chemical industry processes.

• MeSH
• amoniak MeSH
• iontové kapaliny * MeSH
• lidé MeSH
• reprodukovatelnost výsledků MeSH
• rozpouštědla MeSH
• teplota MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Vine tea, a Chinese herbal medicine, is widely used in traditional Asian medicine to treat common health problems. Dihydromyricetin (DMY) is the main functional flavonoid compound extracted from vine tea. In recent years, preclinical studies have focused on the potential beneficial effects of dihydromyricetin, including glucose metabolism regulation, lipid metabolism regulation, neuroprotection, and anti-tumor effects. In addition, DMY may play a role in cardiovascular disease by resisting oxidative stress and participating in the regulation of inflammation. This review is the first review that summaries the applications of dihydromyricetin in cardiovascular diseases, including atherosclerosis, myocardial infarction, myocardial hypertrophy, and diabetic cardiomyopathy. We also clarified the underlying mechanisms and signaling pathways involved in the above process. The aim of this review is to provide a better understanding and quick overview for future researches of dihydromyricetin in the field of cardiovascular diseases, and more detailed and robust researches are needed for evaluation and reference.

• MeSH
• čaj MeSH
• flavonoly farmakologie   terapeutické užití   MeSH
• kardiovaskulární nemoci * farmakoterapie   MeSH
• lidé MeSH
• oxidační stres MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• Publikační typ
• abstrakt z konference MeSH