Filipovsky, Jan* Dotaz Zobrazit nápovědu
- MeSH
- kardiovaskulární nemoci * MeSH
- vnitřní lékařství MeSH
- Publikační typ
- biografie MeSH
- O autorovi
- Filipovský, Jan, 1958- Autorita
- MeSH
- epidemiologie MeSH
- hypertenze MeSH
- kardiologie MeSH
- mezinárodní spolupráce MeSH
- společnosti lékařské MeSH
- vnitřní lékařství MeSH
- vzdělávání odborné MeSH
- Publikační typ
- biografie MeSH
- O autorovi
- Filipovský, Jan, 1958- Autorita
- O autorovi
- Filipovský, Jan, 1958- Autorita
- MeSH
- dospělí MeSH
- hydrokortison krev MeSH
- hypertenze etiologie patofyziologie MeSH
- inzulin krev MeSH
- krevní glukóza analýza MeSH
- kyseliny mastné neesterifikované krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita komplikace MeSH
- prospektivní studie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
OBJECTIVE: Accumulation of advanced glycation end-products (AGE) has been suggested to be involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, thus preventing them from binding to the cell-surface receptor (RAGE) and protecting against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness. DESIGN AND METHOD: In a cross-sectional design, we analyzed 1077 subjects, aged 25 to 64 years, from the Czech population-based study ("Post-MONICA"). Aortic pulse wave velocity (aPWV) measured by the Sphygmocor device, was used to assess aortic stiffness. sRAGE concentrations were assessed in frozen samples by ELISA methods (R&D Systems). RESULTS: Aortic PWV significantly (p < 0.0001) decreased across the sRAGE quartiles. After adjustment for all potential confounders, non-diabetic subjects in the bottom quartile of sRAGE (< 918 pg/mL) had odds ratio of raised aortic PWV (≥ 9.3 m/sec, top quartile) 1.8 (95% CI: 1.19-2.72, p = 0.006); the association was stronger when only hypertensive non-diabetic individuals were included: their odds ratio was 2.05 (95%CI: 1.26-3.32, p = 0.004). In contrast, using similar regression models, low sRAGE was rejected as an independent predictor of raised aortic aPWV in diabetic or in normotensive subjects. CONCLUSIONS: Low circulating sRAGE was independently associated with increased arterial stiffness in a general population-based sample, but mainly in hypertensive non-diabetic patients. The lack of association in diabetics was probably due to low dispersion of sRAGE values and relatively small number of subjects (9% of the sample).
- Publikační typ
- časopisecké články MeSH
- MeSH
- biomedicínský výzkum MeSH
- dospělí MeSH
- hemodynamika farmakologie MeSH
- interpretace statistických dat MeSH
- krevní tlak farmakologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření krevního tlaku statistika a číselné údaje MeSH
- srdeční frekvence farmakologie MeSH
- stárnutí farmakologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- Publikační typ
- klinické zkoušky MeSH
BACKGROUND: Central systolic blood pressure (cSBP) can be derived by the general transfer function of the radial pressure wave, as used in the SphygmoCor device, or by regression equation from directly measured late systolic shoulder of the radial pressure wave (pSBP2), as used in the Omron HEM-9000AI device. The aim of this study was to compare the SphygmoCor estimates of cSBP with 2 estimates of cSBP provided by the Omron HEM-9000AI (cSBP, pSBP2) in a large cohort of the white population. METHODS: In 391 patients aged 52.3±13.5 years (46% men) from the Czech post-MONICA Study, cSBP was measured using the SphygmoCor and Omron HEM-9000AI devices in random order. RESULTS: Omron cSBP and pSBP2 were perfectly correlated (r = 1.0; P < 0.0001). There was a strong correlation (r = 0.97; P < 0.0001) between Omron and SphygmoCor cSBP estimates, but Omron estimate was 13.1±4.7mm Hg higher than SphygmoCor cSBP. On the other hand, Omron pSBP2 strongly correlated with SphygmoCor cSBP (r = 0.97; P < 0.0001) and was 1.7±4.2mm Hg lower than SphygmoCor cSBP. In multivariable analysis, anthropometric and cardiovascular risk factors explained only 10% of the variance of the cSBP difference between devices while explaining 52% of the systolic blood pressure amplification variance. CONCLUSIONS: Estimation of cSBP based on the late systolic shoulder of the radial wave provides a comparable accuracy with the validated general transfer function. When comparing Omron HEM-9000AI and SphygmoCor estimates of cSBP, Omron pSBP2 should be used. The difference between both devices in cSBP may be explained by differences in calibration.
- MeSH
- arteria brachialis fyziologie MeSH
- dospělí MeSH
- kardiovaskulární nemoci etiologie MeSH
- krevní tlak fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření krevního tlaku přístrojové vybavení MeSH
- rizikové faktory MeSH
- senioři MeSH
- systola MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- břicho anatomie a histologie MeSH
- dospělí MeSH
- index tělesné hmotnosti MeSH
- kardiovaskulární nemoci mortalita MeSH
- krevní tlak MeSH
- lidé středního věku MeSH
- lidé MeSH
- mortalita MeSH
- nádory mortalita MeSH
- prospektivní studie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
