Functionality
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The pervasive use of electronic records in healthcare increases the dependency on technology due to the lack of a physical support for the records. Downtime in the EHR system is unavoidable, due to software, infrastructure, energy failures or even natural disasters, so there is a need to develop a contingency plan ensuring patient care continuity and minimizing risks on health care delivery. To mitigate these risks, an application was developed allowing healthcare delivery providers to retrieve medication prescriptions for inpatient or emergency care patients using the CDA R2 document repository as information source. In this paper we describe the strategy and the implementation results.
Fenomén rozpadu rodiny je v současné době často diskutovaným tématem. Společně se zvyšujícím se počtem rozvodů narůstá i počet neúplných rodin, tj. rodin, kde matka či otec vychovávají sami alespoň jedno dítě. Již samotná definice neúplné rodiny vyznívá negativně, něco jí chybí, není úplná. To ovšem nemusí znamenat, že taková rodina nesplňuje kritéria rodiny funkční. Na rodinu můžeme pohlížet z několika hledisek, hledisko dítěte však zůstává povětšinou stranou. Funkčnost či nefunkčnost každé rodiny vážným způsobem ovlivňuje vývoj a socializaci dítěte. Poslední šetření funkčnosti rodiny proběhlo v 80. letech minulého století prostřednictvím Dotazníku funkčnosti rodin ve vztahu k dítěti prof. MUDr. Jiřího Dunovského, DrSc. Tohoto aktualizovaného dotazníku bylo použito ke zjištění úrovně funkčnosti neúplných – rozvedených rodin. Pro získání potřebných dat byla použita metoda sběru dat – dotazování. Zvolenou technikou byl dotazník. Funkčnost rodiny je posuzována na základě těchto kritérií: složení rodiny, stabilita rodiny, sociálně ekonomická situace, osobnost rodiče, sourozenci a jejich osobnost, stav a vývoj šetřeného dítěte, zájem o dítě a péče o dítě.
The phenomenon of the family break-up is currently a frequently discussed theme. Together with increasing rate of divorces, the number of incomplete families also increases, where either the mother alone or the father alone brings up at least one child. The definition of the incomplete family itself sounds negatively – something is missing, it is not complete. However, this does not mean that this family does not adhere to criteria of the functional family. The family can be considered based on several standpoints, but the standpoint of the child usually steps aside. The functionality or non-functionality of any family seriously affects the child development and socialization. The most recent examination of the family functionality was implemented in the 1980´s with the use of the Questionnaire of the family functionality in a relationship to the child by prof. MUDr. Jiří Dunovský, DrSc. This updated questionnaire was employed to establish the level of the functionality of incomplete – divorced families. The data necessary were acquired by the inquiry data accumulation method. The questionnaire served as the technique chosen. The family functionality is considered based on the following criteria: family structure, family stability, social and economical situation, personality of the parent, brothers and sisters and their personality, condition and development of the child examined, interest in the child and taking care of the child.
- MeSH
- dítě MeSH
- lidé MeSH
- neúplná rodina MeSH
- průzkumy a dotazníky MeSH
- rodina psychologie MeSH
- rodinné vztahy MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
Ciel práce: Náš výskum bol zameraný na sledovanie efektívnosti rehabilitačnej liečby pacientok po abdominálnej a vaginálnej hysterektómii. Vo výskume sme hodnotili príznaky inkontinencie a funkčný stav svalov panvového dna. Súbor: Pozostával zo 66 pacientok, z uvedeného počtu bolo 21 žien po vaginálnej hysterektómii a 45 žien abdominálnej hysterektómii. Typ štúdie: Experimentálna prospektívna štúdia. Použité metódy: EMG – biofeedback na hodnotenie funkčného stavu panvového dna podľa Perfekt schémy. Na kvantifikáciu uniknutého moču sme použili 1-hodinový vložkový test. Rehabilitačné metódy: Aplikovali sme individuálne cvičenie na posilnenie a uvoľnenie svalov panvového dna s využitím biofeedbacku prostredníctvom opakovanej selektívnej, vôľovej kontrakcie a relaxácie svalov panvového dna, ktoré sme realizovali dvakrát denne v dĺžke trvania 15 minút. Skupinové cvičenie na posilnenie a uvoľnenie svalov panvového dna, sme realizovali dvakrát týždenne v dĺžke trvania 30 minút. Výsledky: U pacientok po vaginálnej hysterektómii bol vyšší výskyt inkontinencie ako u pacientok po abdominálnej hysterektómii. U oboch skupín pacientok došlo k štatisticky významnému zvýšeniu sily svalov panvového dna po liečbe. Ani u jednej zo sledovaných skupín nedošlo k významnej relaxácii m. rectus abdominis po liečbe. Pacientky po abdominálnej hysterektómii mali štatisticky významne viac relaxované brušné svaly pred liečbou ako pacientky po vaginálnej hysterektómii. To znamená, že realizovali cvičenie správnym spôsobom s redukciou vnútrobrušného tlaku. Domnievame sa, že tento jav môže súvisieť s väčším percentom výskytu inkontinencie u pacientok po vaginálnej hysterektómii.
Objective: Our research deals with the efficiency of rehabilitation in patients after vaginal and abdominal hysterectomy. The activation of pelvic floor muscles has been evaluated and comparison of individual parameters according has been carried out. Also the occurrence of incontinence has been assessed. Subjects consisted of 66 women, out of which there were 21 women after vaginal hysterectomy and 45 women after abdominal hysterectomy. Type of study: Prospective experimental study. Methods use: EMG – biofeedback has been used for the evaluation of the functionality of pelvic floor according to Perfect Scheme. For the quantification of leaked urine one hour PW test has been used. Rehabilitation methods: We applied the individual exercise on strengthening and relaxation of pelvic floor muscles with the aid of repeated, selective voluntary contractions or relaxation of pelvic floor muscles conducted two times a week, with the duration time of 15 minutes. Group exercise on strengthening and relaxation of pelvic floor muscles conducted two times a week, with the duration time of 30 minutes. Biofeedback (EMG-Module) as a therapeutic method was applied. Results: In patients after vaginal hysterectomy there was a higher occurrence of incontinence than in women after abdominal hysterectomy. In both groups a significant increase in pelvic floor muscle strength has been achieved after the therapy. In both of these groups there was no statistically significant relaxation of m. rectus abdominis after the therapy. The patients after abdominal hysterectomy had more statistically significant relaxed abdomen muscles before treatment than patients after vaginal hysterectomy. It means, that performed exercise in the right manner, with reduction of intra abdominal pressure. We suppose that this phenomenon may be related to the higher percentage of occurrence of incontinence in patients after vaginal hysterectomy.
- MeSH
- biofeedback (psychologie) metody MeSH
- elektromyografie metody MeSH
- hysterektomie vaginální rehabilitace statistika a číselné údaje MeSH
- hysterektomie rehabilitace statistika a číselné údaje MeSH
- lidé MeSH
- pánevní dno fyziologie patofyziologie MeSH
- pooperační komplikace etiologie MeSH
- stresová inkontinence moči prevence a kontrola rehabilitace MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
BACKGROUND/AIM: Multiple myeloma is a highly heterogeneous disease of clonal plasma cells. Histone deacetylase (HDAC) inhibitors are promising anticancer drugs but their precise mechanisms of actions are not well understood. MATERIALS AND METHODS: Cell-cycle regulation and pro-apoptotic effects of two histone deacetylase inhibitors, suberohydroxamic acid (SAHA) and suberoylanilide hydroxamic acid (SBHA), were analyzed in multiple myeloma cell lines RPMI8226 and U266 with differing TP53 status using gene-expression analysis. RESULTS: Enhanced expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21WAF/CIP1) detected in the TP53-deleted U266 cell line after SAHA treatment indicates the P53-independent mode of transcriptional activation of CDKN1A gene. In contrast, CDKN1A gene expression was significantly increased by both SBHA and SAHA treatment of TP53-mutated RPMI8226 cells. CONCLUSION: SAHA appears to be a potentially effective pro-apoptotic and anticancer drug with universal application in the treatment of heterogeneous populations of multiple myeloma cells.
- MeSH
- apoptóza účinky léků MeSH
- inhibitor p21 cyklin-dependentní kinasy antagonisté a inhibitory genetika MeSH
- inhibitory histondeacetylas farmakologie MeSH
- kontrolní body buněčného cyklu účinky léků MeSH
- kyseliny hydroxamové farmakologie MeSH
- lidé MeSH
- mnohočetný myelom farmakoterapie genetika metabolismus patologie MeSH
- nádorové buněčné linie MeSH
- nádorový supresorový protein p53 genetika metabolismus MeSH
- protinádorové látky farmakologie MeSH
- regulace genové exprese u nádorů účinky léků MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
Background: Mucosal mast cells (MC) are key players in IgE-mediated food allergy (FA). The evidence on the interaction between gut microbiota, MC and susceptibility to FA is contradictory. Objective: We tested the hypothesis that commensal bacteria are essential for MC migration to the gut and their maturation impacting the susceptibility to FA. Methods: The development and severity of FA symptoms was studied in sensitized germ-free (GF), conventional (CV), and mice mono-colonized with L. plantarum WCFS1 or co-housed with CV mice. MC were phenotypically and functionally characterized. Results: Systemic sensitization and oral challenge of GF mice with ovalbumin led to increased levels of specific IgE in serum compared to CV mice. Remarkably, despite the high levels of sensitization, GF mice did not develop diarrhea or anaphylactic hypothermia, common symptoms of FA. In the gut, GF mice expressed low levels of the MC tissue-homing markers CXCL1 and CXCL2, and harbored fewer MC which exhibited lower levels of MC protease-1 after challenge. Additionally, MC in GF mice were less mature as confirmed by flow-cytometry and their functionality was impaired as shown by reduced edema formation after injection of degranulation-provoking compound 48/80. Co-housing of GF mice with CV mice fully restored their susceptibility to develop FA. However, this did not occur when mice were mono-colonized with L. plantarum. Conclusion: Our results demonstrate that microbiota-induced maturation and gut-homing of MC is a critical step for the development of symptoms of experimental FA. This new mechanistic insight into microbiota-MC-FA axis can be exploited in the prevention and treatment of FA in humans.
- MeSH
- biologické markery MeSH
- buněčná diferenciace genetika imunologie MeSH
- cytokiny metabolismus MeSH
- degranulace buněk genetika imunologie MeSH
- gnotobiologické modely MeSH
- mastocyty imunologie metabolismus MeSH
- metagenom MeSH
- metagenomika metody MeSH
- mikrobiota * imunologie MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- náchylnost k nemoci MeSH
- potravinová alergie etiologie metabolismus patologie MeSH
- RNA ribozomální 16S MeSH
- střevní mikroflóra MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In Alzheimer's disease (AD), tau pathology manifested by the accumulation of intraneuronal tangles and soluble toxic oligomers emerges as a promising therapeutic target. Multiple anti-tau antibodies inhibiting the formation and propagation of cytotoxic tau or promoting its clearance and degradation have been tested in clinical trials, albeit with the inconclusive outcome. Antibodies against tau protein have been documented both in the brain circulatory system and at the periphery, but their origin and role under normal conditions and in AD remain unclear. While it is tempting to assign them a protective role in regulating tau level and removal of toxic variants, the supportive evidence remains sporadic, requiring systematic analysis and critical evaluation. Herein, we review recent data showing the occurrence of tau-reactive antibodies in the brain and peripheral circulation and discuss their origin and significance in tau clearance. Based on the emerging evidence, we cautiously propose that impairments of tau clearance at the periphery by humoral immunity might aggravate the tau pathology in the central nervous system, with implication for the neurodegenerative process of AD.
- MeSH
- Alzheimerova nemoc etiologie metabolismus patologie terapie MeSH
- autoantigeny imunologie MeSH
- autoprotilátky krev imunologie MeSH
- imunoterapie MeSH
- intravenózní imunoglobuliny terapeutické užití MeSH
- lidé MeSH
- náchylnost k nemoci * MeSH
- proteiny tau imunologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
INTRODUCTION: florio® HAEMO is a hemophilia treatment monitoring application (app) offering activity tracking and wearable device connectivity. Its use might support everyday activities for people with hemophilia. The aim of this study was to evaluate user satisfaction, long-term usage and the impact on data entry when pairing a wearable with a hemophilia monitoring app. METHODS: This is a follow-up of a two-part user survey conducted in Central Europe. People with hemophilia and parents/caregivers of children with hemophilia using florio HAEMO and who completed part one were invited to complete a second online questionnaire at least 4 months later. RESULTS: Fifty participants (83.3%) who completed part one of the survey continued to use the florio HAEMO app and completed part two. Of 14 participants who chose to use the app with a wearable, more than half (57.1%) were aged between 13 and 25 years. Overall, the results demonstrated that florio HAEMO is very easy or rather easy to use, especially for individuals pairing the app with a wearable. Most people using a wearable indicated that florio HAEMO was very or rather important in bringing certainty to daily activities (85.7%). Notably, 14 of 36 (38.9%) non-wearable users indicated that they would prefer to pair the app with a wearable in the future. CONCLUSIONS: Adherence to the florio HAEMO app is maintained over an extended period of use. Pairing the app with a wearable might enable easier access to app features, increase data entry motivation and provide more certainty about daily activities for people with hemophilia.
- MeSH
- adherence pacienta statistika a číselné údaje MeSH
- dítě MeSH
- dospělí MeSH
- hemofilie A * MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mobilní aplikace MeSH
- nositelná elektronika * MeSH
- pacientova volba * MeSH
- průzkumy a dotazníky MeSH
- spokojenost pacientů MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
