High flow oxygen
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Vysoko prietoková nazálna oxygenoterapia (HFNO) je forma respiračnej podpory, ktorá je využívaná na efektívnu liečbu hypoxemickej respiračnej insuficiencie. Princípom liečby je inhalácia vysokých prietokov vzduchu zmiešaného s kyslíkom, ktorý je ohriaty a zvlhčený. V súčasnosti počas pandémie ochorenia covid-19 je pre vysoký záujem o HFNO liečbu akútny nedostatok prístrojov od štandardných dodávateľov. Prezentovaná práca dokumentuje experimentálnu liečbu vytvorenú z dostupných zdrojov a pomocou bežného CPAP prístroja, využiteľnú ako núdzové HFNO.
... Nikolaev (Russia) r: 40 -- A study on supersonic chemical oxygen-iodine laser with a high-performance ... ... Piper (Australia) 47 -- XV International Symposium on Gas Flow and Chemical Lasers & High Power Laser ... ... Golubev (Russia) 92 -- XV International Symposium on Gas Flow and Chemical Lasers & High Power Laser ... ... Schall (Germany) 119 -- Optimization of cross-flow jet-type singlet oxygen generator for ejector-COIL ... ... Druginin (Russia) 157 -- Numerical simulation of supersonic-flow chemical oxygen-iodine laser with high ...
1st ed. 209 s. ; 30 cm
Téma bylo zpracováno formou diplomové práce, která se zabývá podpůrnými respiračními, ventilačními a neinvazivními technikami dechové podpory, které souvisejí s celosvětovou pandemií covidu-19, která v období 2020–2021 ovlivnila život mnoha lidí. Během pandemie se v nemocnicích rozšířila terapie vysokoprůtokovým nosním kyslíkem (HFNC –high-flow nasal cannul; high-flow) jakožto možná alternativa umělé plicní ventilace (UPV) u covid pozitivních pacientů. Práce se zabývá problematikou, zda HFNC může být alternativou UPV u covid pozitivních pacientů v intenzivní péči. Empirická část vyplývá z kvantitativních výzkumů. První výzkum byl zaměřen na sestry a jejich zkušenosti a znalosti s technikou HFNC, jejím principem a fungováním, a to prostřednictvím rozeslaných dotazníků. Druhý výzkum byl zpracován sběrem sekundárních dat za pomoci statistické analýzy. Ve druhém kvantitativním šetření bylo cílem znázornění ventilačních režimů u všech hospitalizovaných pacientů, kteří podstoupili terapii na UPV či HFNC, zjistit, zda je HFNC alternativou UPV u covid pozitivních pacientů a zda nedošlo k jejímu selhání během terapie.
The topic was explored through a master’s thesis that focuses on supportive respiratory, ventilatory, and non-invasive techniques of respiratory assistance related to the global covid-19 pandemic, which affected the lives of many people during the period of 2020–2021. During this pandemic, the use of high-flow nasal oxygen therapy (high-flow) proliferated in hospitals as a potential alternative to invasive mechanical ventilation for covid-positive patients. The thesis addresses the question of whether high-flow can serve as an alternative to invasive mechanical ventilation for covid-positive patients in intensive care. The empirical part is derived from quantitative research. The first study focused on nurses and their experiences and knowledge of the high-flow technique, its principles, and its functioning, through distributed questionnaires. The second study utilized secondary data collection and statistical analysis. In the second quantitative investigation, the goal was to depict ventilation strategies in all hospitalized patients who underwent therapy with either invasive mechanical ventilation or high-flow, to determine whether high-flow can serve as an alternative to invasive mechanical ventilation for covid-positive patients, and whether its failure occurred during the therapy.
OBJECTIVE: To evaluate the efficacy of automatic oxygen control (A-FiO2) in reducing the extremes of oxygen saturations (SpO2<80% and SpO2>98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow. DESIGN: A parallel-arm randomised controlled trial. SETTING: A level-III neonatal intensive care unit. PATIENTS: Preterm infants born <33 (23+0 to 32+6) weeks receiving HFNC as respiratory support. INTERVENTIONS: A-FiO2 versus manual (M-FiO2) oxygen control during the full course of HFNC support. OUTCOMES: The primary outcome of this study is percentage of time spent in extreme oxygen saturations (<80% and >98%) in preterm infants when receiving HFNC as respiratory support. Secondary outcomes were time with SpO2 between 90% and 95% plus time >95% without supplemental oxygen. RESULTS: 60 infants were randomised equally to either A-FiO2 or M-FiO2 arm. Their baseline characteristics were comparable. They spent a median of 5.3 (IQR: 2.0-8.4) and 6.5 (IQR: 2.9-13.7) days in the study, A-FiO2 and M-FiO2, respectively. The percentage of time spent in SpO2<80% (median of 0.4% (0.1%-0.8%) vs 1.6% (0.6%-2.6%), p=0.002) and >98% (median 0.2% (0.1%-0.9%) vs 1.9% (0.7%-4%), p<0.001) were significantly lower in A-FiO2 compared with M-FiO2. The difference in median percentage of time in target range between the two arms was 26% (81% (74%-93%) in A-FiO2 vs 55% (48%-72%) in M-FiO2). CONCLUSION: A-FiO2 was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO2 in preterm infants receiving HFNC. TRIAL REGISTRATION NUMBER: NCT04687618.
Tradičné metódy aplikácie O2 terapie maskou, binazálnou kanylou (kyslíkové okuliare), Venturiho maskou a podobne, vedú vo väčšine prípadov k nedostatočnému zvlhčovaniu dýchacieho plynu. Nedostatočné zvlhčovanie a ohrievanie plynu, ktorý pacient dýcha, vedie k vysušovaniu slizníc, s ďalšími následkami pre pacienta. Použitie systému ventilačnej podpory vysokým prietokom plynov aplikovaným nazálne – high flow nasal ventilation (HFloNV) na aplikáciu oxygenoterapie relatívne nízkymi prietokmi O2 do 15 – 20 l/min je zvyčajne pacientom tolerované s podstatne väčším komfortom. Prinášame pohľad (komparáciu) na tradičnú oxygenoterapiu a vysokoprietokovú nazálnu ventiláciu.
Traditional methods of applying O2 therapy with a mask, binasal cannula (oxygen glasses), Venturi mask and the like, in most cases lead to insufficient humidification of the breathing gas. Insufficient humidification and heating of the gas that the patient breathes leads to drying of the mucous membranes, with further consequences for the patient. The use of a high flow nasal ventilation (HFloNV) system for the application of oxygen therapy with relatively low O2 flows up to 15 - 20 l / min is usually tolerated by patients with significantly greater comfort. We present a view (comparison) of traditional oxygen therapy and high-flow nasal ventilation.
- Klíčová slova
- vysokoprůtoková nazální terapie O2,
- MeSH
- oxygenoterapie ošetřování MeSH
Téma bylo zpracováno formou diplomové práce, která se zabývá podpůrnými respiračními, ventilačními a neinvazivními technikami dechové podpory, které souvisejí s celosvětovou pandemií covidu-19, která v období 2020–2021 ovlivnila život mnoha lidí. Během pandemie se v nemocnicích rozšířila terapie vysokoprůtokovým nosním kyslíkem (HFNC –high-flow nasal cannul; high-flow) jakožto možná alternativa umělé plicní ventilace (UPV) u covid pozitivních pacientů. Práce se zabývá problematikou, zda HFNC může být alternativou UPV u covid pozitivních pacientů v intenzivní péči. Empirická část vyplývá z kvantitativních výzkumů. První výzkum byl zaměřen na sestry a jejich zkušenosti a znalosti s technikou HFNC, jejím principem a fungováním, a to prostřednictvím rozeslaných dotazníků. Druhý výzkum byl zpracován sběrem sekundárních dat za pomoci statistické analýzy. Ve druhém kvantitativním šetření bylo cílem znázornění ventilačních režimů u všech hospitalizovaných pacientů, kteří podstoupili terapii na UPV či HFNC, zjistit, zda je HFNC alternativou UPV u covid pozitivních pacientů a zda nedošlo k jejímu selhání během terapie.
The topic was explored through a master’s thesis that focuses on supportive respiratory, ventilatory, and non-invasive techniques of respiratory assistance related to the global covid-19 pandemic, which affected the lives of many people during the period of 2020–2021. During this pandemic, the use of high-flow nasal oxygen therapy (high-flow) proliferated in hospitals as a potential alternative to invasive mechanical ventilation for covid-positive patients. The thesis addresses the question of whether high-flow can serve as an alternative to invasive mechanical ventilation for covid-positive patients in intensive care. The empirical part is derived from quantitative research. The first study focused on nurses and their experiences and knowledge of the high-flow technique, its principles, and its functioning, through distributed questionnaires. The second study utilized secondary data collection and statistical analysis. In the second quantitative investigation, the goal was to depict ventilation strategies in all hospitalized patients who underwent therapy with either invasive mechanical ventilation or high-flow, to determine whether high-flow can serve as an alternative to invasive mechanical ventilation for covid-positive patients, and whether its failure occurred during the therapy.
OBJECTIVE: The aim of this study was to analyse the long-term radiation effects on human sperm. METHODS: In total, 104 samples of male donors from 2 regions of Ukraine were tested. Group 1 consisted of 32 donors from the Ivano-Frankivsk region, group 2 included 72 volunteers from the Zhytomyr region. The average age of donors in both groups was 35 ± 6 years (range 24-49). To assess the level of apoptosis, membrane mitochondrial potential, concentration of reactive oxygen species, and ploidy of sperm, flow cytometry was performed. RESULTS: The individual equivalent dose of group 1 was < 0.4 mSv and of group 2 ≥ 0.4 mSv. Live spermatozoa with signs of apoptosis were significantly higher (p < 0.05) in group 2 in comparison to group 1 (15.6% and 11.2%, respectively). Spermatozoa without violating integrity were 73.2% in group 1 and approximately 16% higher than the indices of group 2. The percentage of dead necrotic spermatozoa was twice as high in men with a predicted equivalent dose of ≥ 0.4 mSv than in comparison group. A higher percentage of spermatozoa with low mitochondrial membrane potential, di- and tetraploid was found in group 2. CONCLUSIONS: An equivalent individual dose of ≥ 0.4 mSv can cause a decrease in mitochondrial potential, an increase in the production of spermatozoa with pathological ploidy, as well as to provoke increasing apoptosis in cells.
- MeSH
- černobylská havárie * MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- průtoková cytometrie MeSH
- reaktivní formy kyslíku farmakologie MeSH
- sperma MeSH
- spermie patologie účinky záření MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
... Continuous positive airway pressure 34 -- 5.1 Bubble CPAP 34 -- 5.2 Flumidified high flow through nasal ... ... prongs 37 ill -- OXYGEN THERAPY FOR CHILDREN -- 6. ... ... Monitoring the progress of children on oxygen 42 -- 7.1 When to stop oxygen 43 -- 7.2 General care of ... ... Administration of oxygen with oxygen concentrators 53 -- Annex 3. ... ... Administration of oxygen from oxygen cylinders 56 iv ...
vi, 57 stran : ilustrace, tabulky ; 24 cm
- MeSH
- dítě hospitalizované MeSH
- hypoxie prevence a kontrola MeSH
- oxygenoterapie MeSH
- pneumonie komplikace MeSH
- Konspekt
- Pediatrie
- NLK Obory
- pediatrie
- NLK Publikační typ
- publikace WHO
