Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-κB activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-γ-schisandrin, rubrisandrin A, and (-)-gomisin J.
Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46.4%, we found that: (i) Hypericum perforatum (St. John's Wort) is the most studied and supported adaptogen (17/41 [41.46%], three systematic reviews with meta-analysis) followed by Crocus sativus L. or saffron (6/41 [14.63%], three systematic reviews with meta-analysis and two systematic reviews); (ii) it is possible that the significantly better performance of adaptogens over placebo is due to the reduction of allostatic load via the action of secondary metabolites on BDNF regulation; and, (iii) the number of studies reporting physical activity levels is limited or null for those that combine an exercise program with the consumption of adaptogens. Aware of the need for a multidisciplinary approach for depression treatment, this systematic integrative review provides an up-to-date view for supporting the use of St. John's Wort and saffron as non-pharmacological strategies while also help commissioning future research on the efficacy of other adaptogens. It also contributes to the design of future clinical research studies that evaluate the consumption of herbal extracts plus physical exercise, mainly resistance training, as a potentially safe and powerful strategy to treat depression.
... 169 -- Také astromedicína má svoje zákonitosti 179 -- Adaptogeny připomínají zázrak 193 -- Emil Havelka ...
1. elektronické vydání 1 online zdroj (328 stran)
Vstupte do světa astrologie. Seznámíte se s charakteristikou reprezentantů každého z 12 měsíčních znamení i tvorbou rozmanitých druhů horoskopů - jízdního řádu našich životů. Přečtete si také o neduzích a nemocech, které mohou zrozence jednotlivých znamení trápit. Nahlédnete také do seznamky s planetami. Hlavně však poznáte až zázračné léčitelské schopnosti astrologa Emila Václava Havelky zvaného český Nostradamus, muže, jenž léčil politiky, bankéře, doktory, policisty, umělce i běžné klienty. V druhém vydání navíc najdete nové dosud nepublikované fotky.; Setkání s jedním z 10 nejuznávanějších astrologů.Vstupte do světa astrologie. Seznámíte se s charakteristikou reprezentantů každého z 12 měsíčních znamení i tvorbou rozmanitých druhů horoskopů – jízdního řádu našich životů. Přečtete si také o neduzích a nemocech, které mohou zrozence jednotlivých znamení trápit. Nahlédnete také do seznamky s planetami. Hlavně však poznáte až zázračné léčitelské schopnosti astrologa Emila Václava Havelky zvaného český Nostradamus, muže, jenž léčil politiky, bankéře, doktory, policisty, umělce i běžné klienty.
Rhaponticum carthamoides, maral root, is being used, namely in Orient, for centuries. The focus of interest of medicinal chemists has recently been pointed to its chemical components, namely 20-hydroxyecdysone, a herbal drug with very low toxicity. It is registered in the EU to cure, e.g., Duchenne muscular dystrophy. Moreover, being recognised as an adaptogen, it has been in use to cure prediabetes and can be classified as a natural substance, for which intensive research into cancer and leukaemia treatment is running, in some cases together with bufadienolides. Ecdysteroids also have the ability to affect drug resistance in the treatment of tumours. The paper brings the digest of the most interesting information, mainly from the human health research.
Ageing is an enigmatic and progressive biological process which undermines the normal functions of living organisms with time. Ageing has been conspicuously linked to dietary habits, whereby dietary restrictions and antioxidants play a substantial role in slowing the ageing process. Oxygen is an essential molecule that sustains human life on earth and is involved in the synthesis of reactive oxygen species (ROS) that pose certain health complications. The ROS are believed to be a significant factor in the progression of ageing. A robust lifestyle and healthy food, containing dietary antioxidants, are essential for improving the overall livelihood and decelerating the ageing process. Dietary antioxidants such as adaptogens, anthocyanins, vitamins A/D/C/E and isoflavones slow the ageing phenomena by reducing ROS production in the cells, thereby improving the life span of living organisms. This review highlights the manifestations of ageing, theories associated with ageing and the importance of diet management in ageing. It also discusses the available functional foods as well as nutraceuticals with anti-ageing potential.
- MeSH
- Antioxidants administration & dosage MeSH
- Longevity MeSH
- Functional Food MeSH
- Plants, Edible * MeSH
- Humans MeSH
- Oxidative Stress MeSH
- Dietary Supplements * MeSH
- Reactive Oxygen Species analysis MeSH
- Aging physiology MeSH
- Diet, Healthy methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The target diosgenin-betulinic acid conjugates are reported to investigate their ability to enhance and modify the pharmacological effects of their components. The detailed synthetic procedure that includes copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (click reaction), and palladium-catalyzed debenzylation by hydrogenolysis is described together with the results of cytotoxicity screening tests. Palladium-catalyzed debenzylation reaction of benzyl ester intermediates was the key step in this synthetic procedure due to the simultaneous presence of a 1,4-disubstituted 1,2,3-triazole ring in the molecule that was a competing coordination site for the palladium catalyst. High pressure (130 kPa) palladium-catalyzed procedure represented a successful synthetic step yielding the required products. The conjugate 7 showed selective cytotoxicity in human T-lymphoblastic leukemia (CEM) cancer cells (IC50 = 6.5 ± 1.1 µM), in contrast to the conjugate 8 showing no cytotoxicity, and diosgenin (1), an adaptogen, for which a potential to be active on central nervous system was calculated in silico. In addition, 5 showed medium multifarious cytotoxicity in human T-lymphoblastic leukemia (CEM), human cervical cancer (HeLa), and human colon cancer (HCT 116). Betulinic acid (2) and the intermediates 3 and 4 showed no cytotoxicity in the tested cancer cell lines. The experimental data obtained are supplemented by and compared with the in silico calculated physico-chemical and absorption, distribution, metabolism, and excretion (ADME) parameters of these compounds.
- MeSH
- Cycloaddition Reaction MeSH
- Diosgenin chemistry MeSH
- Hydrogenation MeSH
- Catalysis MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Palladium chemistry MeSH
- Pentacyclic Triterpenes chemistry MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Pressure MeSH
- Cell Survival drug effects MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
... Glutathion 137 -- Betaglukany 138 -- Bakteriální lyzáty 138 -- Byliny pro imunitní systém 139 -- Adaptogeny ...
177 stran : ilustrace, tabulky ; 22 cm
Příručka se zabývá imunitním systémem a jak ho posílit zdravým životním stylem. Určeno široké veřejnosti.; Naše zdraví, životní rovnováha a délka života souvisejí s tím, jak funguje náš imunitní systém, naše obranyschopnost. Armáda buněk, která do něj patří, stojí na stráži a stará se o to, aby do našeho těla nevnikly škodlivé mikroorganismy a cizorodé látky. Silný imunitní systém znamená zdraví a vitalitu, protože nás chrání před infekcemi a také před rakovinnými buňkami. V této knize se seznámíte s tím, jak imunitní systém funguje, s faktory, které jej oslabují, a především s možnostmi, jak je aktivně ovlivnit. Dozvíte se, jak životosprávou - kam patří třeba vyvážená strava, protistresové techniky, pohyb nebo kvalita spánku - zdravě posílit obranyschopnost a prodloužit si život. Pomohou vám také doplňky stravy, byliny a jejich směsi, které autor ověřil svojí dlouholetou praxí.
- MeSH
- Immune System MeSH
- Plants, Medicinal MeSH
- Health Promotion MeSH
- Dietary Supplements MeSH
- Risk Factors MeSH
- Healthy Lifestyle MeSH
- Publication type
- Popular Work MeSH
- Handbook MeSH
- Conspectus
- Hygiena. Lidské zdraví
- NML Fields
- alergologie a imunologie
- preventivní medicína
... 106 -- Léčivá síta dřevin 113 -- Zahradní bylinky a užitkové rostliny s léčivými účinky 115 -- Adaptogeny ...
1. elektronické vydání 1 online zdroj (280 stran)
Majitelům zahrad se nabízí mnoho možností, jak k zahradní tvorbě přistupovat, jak se o zahradu starat. Současným trendem je propojit okrasné rostliny s planými, avšak zdraví prospěšnými druhy v jeden harmonický celek. V knize najdete i četné rady na využití zahradních plevelů k léčení těla i duše.
Schisandra čínská (Schisandra chinensis) je po staletí používanou rostlinou tradiční čínské medicíny. Její biologická aktivita a farmakologické využití jsou spojovány s obsahovými látkami typu dibenzocyklooktadienových lignanů a literatura zmiňuje také přítomnost specifických polysacharidů. Lignany schisandry jsou rodově specifické. Jejich aktivita byla zkoumána ve stovkách studií, které potvrdily adaptogenní účinky, stimulační vliv na centrální nervovou soustavu, hepatoprotektivní účinky a také možný protirakovinný potenciál. Předkládaná práce přináší shrnutí obsahových látek schisandry, popis lidového využití extraktů, přehled klinických studií a doplňující informace o in vitro testech vnášejících náhled do mechanismů účinku.
Schisandra (Schisandra chinensis) has been used for centuries as a plant of traditional Chinese medicine. Its biological activity and pharmacological use are associated with dibenzocyclooctadiene lignans, while specific polysaccharides may also be involved. The lignans of schisandra are genus-specific. Their activity has been investigated in hundreds of studies that have confirmed adaptogenic effects, central nervous system stimulation, hepatoprotective effects and potential anticancer potential. This summary review of the literature synthesizes the current state-of-the-art in research on bioactivities of schisandra constituents, description of folk use of extracts, overview of clinical studies and additional information on in vitro tests bringing insight into mechanisms of action.
INTRODUCTION: Alzheimer's disease (AD) is a progressive, neurodegenerative disorder prevalent worldwide among elderly populations. Owing to limited efficacy, side effects, and poor patient compliance for current rationally designed therapies, options are being searched from alternate therapies such as Indian (Ayurvedic), Chinese, or other traditional systems. Areas covered: Following a comprehensive literature search, the authors provide a review encompassing: (1) pathophysiological changes involved in AD, (2) Ayurvedic holistic approach and herbal medicines to manage dementia and AD, and (3) traditional plants and their phytoconstituents effective in AD with description of possible mechanism of action. Expert opinion: Traditional remedies could be adjunct therapeutic options to allay wide-ranging pathological cascades of AD. Ayurveda offers a holistic approach of treatment along with a list of nootropic herbs and formulations that are the rich sources of antioxidants, anti-amyloidogenic, neuroprotective, adaptogenic, anti-inflammatory, and immunomodulatory compounds that are found to modulate neuroendocrine-immune activities, enhance memory, intellect, rejuvenate brain functions, and improve quality of life. A strong knowledge base of traditional systems coupled with contemporary science may provide new functional leads for age-associated neurodegenerative disorders at preventive, promotive, and curative levels, and evolution of new drug therapies and development processes, though further research is needed.
- MeSH
- Medicine, Ayurvedic * MeSH
- Alzheimer Disease drug therapy physiopathology therapy MeSH
- Phytotherapy * MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
