beta-titanium alloy Dotaz Zobrazit nápovědu
Článek se zabývá ortodontickými dráty zhotovenými ze slitin titanu, se zvláštním přihlédnutím k titanové slitině beta III. Je podán popis struktury titanových slitin, jejich mechanické a technologické vlastnosti a postavení beta titanu v sortimentu ortodontických drátů.
The orthodontic wires of beta-titanium alloys are reported, with special reference to beta III titanium alloy. Titanium alloy structure and its mechanical and technological properties are described as well as the position of beta-titanium among the assortment of orthodontic wires.
- MeSH
- ortodontické dráty MeSH
- slitiny chemie terapeutické užití MeSH
- titan terapeutické užití MeSH
- Publikační typ
- přehledy MeSH
AIM: TheAIM of this study was to use the beta-titanium alloy Ti38Nb6Ta for production of a new construction line of implants, perform testing on animals and preclinical tests. MATERIALS AND METHODS: Within this study, a new PV I implant with five construction variants was developed. The implant includes three types of threads - microthreads and flat threads of two types with a different depth. Further, the PV I implant was tested on minipigs. Subsequently, preclinical tests of 150 implants were performed and assessed. The age interval of patients was from 18 to 74 years. RESULTS: Beta titanium alloy exhibited higher strength than titanium alloys. Anti-corrosion resistance was also higher. The implant from beta-alloy was inserted in the tibias of minipigs. Sections showed good osseointegration of the PV I implant. During the preclinical tests, 150 implants were inserted with the success rate of 99.33% after the two year assessment. The assessment also included handicapped patients who are not usually assessed in classical studies. Finally, the implantation protocol and documentation of a new implantation system PV I was designed. At the same time the industrial sample of this implant was formed and accepted. CONCLUSION: A new anti-rotation PV I implant with microthreads and conical anchorage of the abutment into the fixture was formed. The beta-titanium alloy Ti38Nb6Ta used for the implant was biocompatible and had higher mechanical and physical properties than the existing titanium alloys. The PV I implant was recommended for clinical application.
- MeSH
- čelist bezzubá chirurgie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- postižení * MeSH
- protézy - design MeSH
- senioři MeSH
- testování materiálů MeSH
- titan farmakologie MeSH
- zubní implantáty * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
Beta titanium alloys are promising materials for load-bearing orthopaedic implants due to their excellent corrosion resistance and biocompatibility, low elastic modulus and moderate strength. Metastable beta-Ti alloys can be hardened via precipitation of the alpha phase; however, this has an adverse effect on the elastic modulus. Small amounts of Fe (0-2 wt.%) and Si (0-1 wt.%) were added to Ti-35Nb-7Zr-6Ta (TNZT) biocompatible alloy to increase its strength in beta solution treated condition. Fe and Si additions were shown to cause a significant increase in tensile strength and also in the elastic modulus (from 65 GPa to 85 GPa). However, the elastic modulus of TNZT alloy with Fe and Si additions is still much lower than that of widely used Ti-6Al-4V alloy (115 GPa), and thus closer to that of the bone (10-30 GPa). Si decreases the elongation to failure, whereas Fe increases the uniform elongation thanks to increased work hardening. Primary human osteoblasts cultivated for 21 days on TNZT with 0.5Si+2Fe (wt.%) reached a significantly higher cell population density and significantly higher collagen I production than cells cultured on the standard Ti-6Al-4V alloy. In conclusion, the Ti-35Nb-7Zr-6Ta-2Fe-0.5Si alloy proves to be the best combination of elastic modulus, strength and also biological properties, which makes it a viable candidate for use in load-bearing implants.
Low-modulus biomedical beta titanium alloys often suffer from low strength which limits their use as load-bearing orthopaedic implants. In this study, twelve different Ti-Nb-Zr-Ta based alloys alloyed with Fe, Si and O additions were prepared by arc melting and hot forging. The lowest elastic modulus (65GPa) was achieved in the benchmark TNTZ alloy consisting only of pure β phase with low stability due to the 'proximity' to the β to α'' martensitic transformation. Alloying by Fe and O significantly increased elastic modulus, which correlates with the electrons per atom ratio (e/a). Sufficient amount of Fe/O leads to increased yield stress, increased elongation to fracture and also to work hardening during deformation. A 20% increase in strength and a 20% decrease in the elastic modulus when compared to the common Ti-6Al-4V alloy was achieved in TNTZ-Fe-Si-O alloys, which proved to be suitable for biomedical use due to their favorable mechanical properties.
- MeSH
- biokompatibilní materiály analýza MeSH
- křemík MeSH
- kyslík MeSH
- modul pružnosti MeSH
- niob MeSH
- slitiny analýza MeSH
- tantal MeSH
- testování materiálů MeSH
- titan MeSH
- zatížení muskuloskeletálního systému MeSH
- železo MeSH
- zinek MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Nanotubes with diameters ranging from 40 to 60nm were prepared by electrochemical oxidation of the Ti-6Al-4V alloy in electrolyte containing ammonium sulphate and ammonium fluoride. The nanotubes were further modified with calcium and phosphate ions or were heat treated. Polished Ti-6Al-4V alloy served as a reference sample. The spreading of human osteoblast-like cells was similar on all nanotube samples but lower than on polished samples. The number of initially adhered cells was higher on non-modified nanotubes, but the final cell number was the highest on Ca-enriched nanotubes and the lowest on heat-treated nanotubes. However, these differences were relatively small and less pronounced than the differences in the concentration of specific molecular markers of cell adhesion and differentiation, estimated by their intensity of immunofluorescence staining. The concentration of vinculin, i.e. a protein of focal adhesion plaques, was the lowest on nanotubes modified with calcium. Collagen I, an early marker of osteogenic cell differentiation, was also the lowest on samples modified with calcium and was highest on polished samples. Alkaline phosphatase, a middle marker of osteogenic differentiation, was observed in lowest concentration on nanotubes modified with phosphorus and the highest on heat-treated samples. Osteocalcin concentrations, a late marker of osteogenic cell differentiation, were similar on all tested samples, although they tended to be the highest on heat-treated samples. Thus, osteogenic differentiation can be modulated by various additional treatments of nanotube coatings on Ti-6Al-4V implants.
- MeSH
- buněčná adheze účinky léků MeSH
- buněčná diferenciace účinky léků MeSH
- fluorescenční mikroskopie MeSH
- kolagen typu I metabolismus MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- nanotrubičky chemie MeSH
- osteoblasty cytologie metabolismus MeSH
- osteokalcin metabolismus MeSH
- titan chemie farmakologie MeSH
- vápník chemie MeSH
- vinkulin chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Práce se zabývá sledováním biologických vlastností binárních slitin titanu s tantalem v závislosti na poměru hmotnostního podílu tantalu ve slitině. Byly provedeny zkoušky cytokompatibility a genotoxicity. Mezi zkoušky cytokompatibility patřily testy růstu buněk, adherence buněk, dynamický dilatační test, test tolerance v monovrstvě a v suspenzi. Mezi zkoušky genotoxicity patřily test indukce atypických mitóz, test indukce chromozomálních aberací v buněčné linii a v periferních lymfocytech člověka. Na základě hodnocení těchto biologických testů byla stanovena vhodnost užití takových slitin v orální implantologii. Takto vytvořené beta slitiny je možné pro výrobu implantátů doporučit.
The paper deals with investigation of biological properties of binary alloys of titanium with tantalum in relation to the ratio of mass share of tantalum in the alloy. Tests of cytocompatibility and genotoxicity have been made. The tests of cytocompatibility included those of cell growth, cell adherence, dilation test, tolerance test in monolayer, and in suspension. The genotoxicity tests encompassed those of induction of atypical mitoses, induction of chromosomal aberrations in a cell line and in human peripheral lymphocytes. Based of the evaluation of these biological tests the authors determined suitability of using such alloys in oral implantology. Beta alloys formed in this way can be recommended for use in the production of implants.
This comparative study of various surface treatments of commercially available implant materials is intended as guidance for orientation among particular surface treatment methods in term of the cell reaction of normal human osteoblasts and blood coagulation. The influence of physicochemical surface parameters such as roughness, surface free energy and wettability on the response of human osteoblasts in the immediate vicinity of implants and on the blood coagulation was studied. The osteoblast proliferation was monitored and the expression of tissue mediators (TNF-alpha, IL-8, MMP-1, bone alkaline phosphatase, VCAM-1, TGF-beta) was evaluated after the cell cultivation onto a wide range of commercially available materials (titanium and Ti6Al4V alloy with various surface treatments, CrCoMo alloy, zirconium oxide ceramics, polyethylene and carbon/carbon composite). The formation of a blood clot was investigated on the samples immersed in a freshly drawn whole rabbit blood using scanning electron microscope. The surfaces with an increased osteoblast proliferation exhibited particularly higher surface roughness (here R(a) 3.5 microm) followed by a high polar part of the surface free energy whereas the effect of wettability played a minor role. The surface roughness was also the main factor regulating the blood coagulation. The blood clot formation analysis showed a rapid coagulum formation on the rough titanium-based surfaces. The titanium with an etching treatment was considered as the most suitable candidate for healing into the bone tissue due to high osteoblast proliferation, the highest production of osteogenesis markers and low production of inflammatory cytokines and due to the most intensive blood clot formation.
- MeSH
- buněčná diferenciace MeSH
- cévní buněčněadhezivní molekula-1 metabolismus MeSH
- financování organizované MeSH
- interleukin-8 metabolismus MeSH
- kultivované buňky MeSH
- lidé MeSH
- osteoblasty cytologie metabolismus MeSH
- povrchové vlastnosti MeSH
- proliferace buněk MeSH
- protézy a implantáty MeSH
- titan chemie metabolismus MeSH
- TNF-alfa metabolismus MeSH
- transformující růstový faktor beta metabolismus MeSH
- vitalium chemie metabolismus MeSH
- Check Tag
- lidé MeSH
Ti-6Al-4V-based nanotubes were prepared on a Ti-6Al-4V surface by anodic oxidation on 10 V, 20 V, and 30 V samples. The 10 V, 20 V, and 30 V samples and a control smooth Ti-6Al-4V sample were evaluated in terms of their chemical composition, diameter distribution, and cellular response. The surfaces of the 10 V, 20 V, and 30 V samples consisted of nanotubes of a relatively wide range of diameters that increased with the voltage. Saos-2 cells had a similar initial adhesion on all nanotube samples to the control Ti-6Al-4V sample, but it was lower than on glass. On day 3, the highest concentrations of both vinculin and talin measured by enzyme-linked immunosorbent assay and intensity of immunofluorescence staining were on 30 V nanotubes. On the other hand, the highest concentrations of ALP, type I collagen, and osteopontin were found on 10 V and 20 V samples. The final cellular densities on 10 V, 20 V, and 30 V samples were higher than on glass. Therefore, the controlled anodization of Ti-6Al-4V seems to be a useful tool for preparing nanostructured materials with desirable biological properties.
- MeSH
- aktiny metabolismus MeSH
- biologické markery metabolismus MeSH
- buněčná adheze účinky léků MeSH
- buněčná diferenciace účinky léků MeSH
- fluorescenční protilátková technika MeSH
- fotoelektronová spektroskopie MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- nanotrubičky chemie MeSH
- osteoblasty cytologie účinky léků MeSH
- osteogeneze účinky léků MeSH
- povrchové vlastnosti MeSH
- proliferace buněk účinky léků MeSH
- titan farmakologie MeSH
- velikost částic * MeSH
- viabilita buněk účinky léků MeSH
- vinkulin metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Cíl: Cílem této práce bylo změřit statické i dynamické tření mezi různými druhy ortodontických drátů in vitro a porovnat zjištěné výsledky mezi skupinami drátů navzájem. Materiál a metodika: Proměřeno bylo celkem 14 ortodontických drátů (velikosti 0,018x0,025 palců). Měření tření probíhalo na přístroji ZWICK1020 u všech 14 ortodontických drátů s pěti druhy ortodontických zámků (z nerezavějící oceli, ze zlata, z plastu, z monokrystalické a polykrystalické keramiky). Všechna měření byla provedena za standardních podmínek v laboratoři, v suchém prostředí a v angulaci 0°, 5° a 10°. Výsledky; Z výsledků práce vyplývá, že statické i dynamické tření se mezi druhy ortodontických drátů statisticky významné liší, nejvyšších hodnot dosahují ortodontické dráty z betatitanových slitin. Závěr: Biologické faktory v ústech lze jen stěží měnit, ale materiál ortodontických drátů patří mezi mechanické faktory, kterými lze ovlivnit velikost tření mezi ortodontickým zámkem a drátem. Přesto je situace in vitro při zkoumaní tření materiálů ortodontických drátů odlišná od situace in vivo v dutině ústní.
Aim: The aim of the presented work was to measure static as well as dyriamic friction in different types of orthodontic archwires in vitro, and to compare the results between the groups of archwires. Material and method: 14 orthodontic archwires (0.018 x 0.025 inches) were measured. The measurements were done with device ZWICK Z020 for all 14 orthodontic archwires and five types of orthodontic brackets (stainless steel, gold, plastic, monocrystalline and polycrystalline ceramics). All measurements were taken under standard conditions in a lab, in a dry environment, and under the angulation 0°, 5°, and 10°. Results: Between individual types of orthodontic archwires, both static and dynamic friction is significantly different The highest values are reported in orthodontic archwires made of beta-titanium alloys. Conclusion: It is hardly possible to change biological factors in mouth, however, the material of orthodontic arch wires is one of mechanical factors through which we can influence the amount of friction between an orthodontic bracket and an arch wire. Nevertheless, we should bear in mind that in vitro situation is different from in vivo conditions of the mouth cavity.
- MeSH
- lidé MeSH
- ortodontické dráty * MeSH
- testování materiálů * metody MeSH
- tření MeSH
- zubní materiály MeSH
- Check Tag
- lidé MeSH
