Cíl: Tato studie se zabývala rozdíly v expresi miR-499 koronárním bypassu (coronary artery bypass grafting, CABG) bez mimotělního oběhu (off-pump) a hodnotila vztah mezi expresí miR-499 na jedné straně a ejekční frakcí levé komory (%) a koncentrací kyseliny močové (uric acid, UA) na straně druhé. Metody a výsledky: Bylo vybráno 70 pacientů indikovaných k CABG a v různých časových bodech u nich byla měřena ejekční frakce levé komory, odebírány krevní vzorky a měřeny hemodynamické údaje. Po CABG bez mimotělního oběhu byla zjištěna statisticky významná korelace mezi hodnotami cirkulujícího srdečního troponinu I (cTnI), UA a miR-499 (p < 0,001). Pooperační hodnota ejekční frakce byla dále silně ovlivněna předoperační mírou exprese miR-499 ve vztahu ke koncentracím UA (p < 0,005). Závěr: Tlakové přetížení a ischemie vyvíjejí oxidační stres (OS) na kardiovaskulární systém. Zvýšená exprese miR-499 v ischemizovaném myokardu jej chrání před OS; současně byla zjištěna nižší ochrana při nižší expresi miR-499 ve vztahu ke koncentracím UA.

Objective: This study screens the miR-499 differences in off-pump CABG and evaluates the relationship of miR-499 with heart ejection fraction (%) and uric acid (UA) levels. Methods and results: 70 candidates undergoing CABG were selected and left ventricular EF, blood samples and hemodynamic data were taken at different time points. Statistically significant correlation was found between circulating levels of cardiac troponin I (cTnI), UA and miR-499, after off-pump CABG (p < 0.001). Furthermore, post-operative EF was strongly affected by pre-operative miR-499 expression levels vs. UA (p < 0.005). Conclusion: Pressure overload and ischemia result in oxidative stress (OS) on the cardiovascular system. The elevated levels of miR-499 expression in ischemic myocardium protect it from OS, while declining protective effects was observed in decreased levels of miR-499 in UA concentrations.

• Klíčová slova
• miR-499,
• MeSH
• biologické markery * krev   MeSH
• dospělí MeSH
• dysfunkce levé srdeční komory MeSH
• exprese genu MeSH
• ischemická choroba srdeční diagnóza   MeSH
• koronární bypass bez mimotělního oběhu MeSH
• kyselina močová MeSH
• lidé středního věku MeSH
• lidé MeSH
• mikro RNA * fyziologie   sekrece   MeSH
• oxidační stres MeSH
• senioři MeSH
• troponin I krev   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH

Background: Obstructive sleep apnea syndrome (OSAS) is one of the most common sleep-related breathing disorders. The aim of this study was to improve diagnostics in OSAS using blood circulating biomarkers. We consider the potential of cardiac-specific miRNAs in the diagnosis and risk assessment of cardiovascular complications. Materials & methods: Plasmatic levels of miR-1-3p, miR-133a-3p and miR-499a-5p were measured by reverse transcription-PCR and compared with the clinical status of OSAS patients and controls. Results: The level of miR-499 was higher (p = 0.0343) in OSAS patients (mean expression: 0.00561) compared with the controls (mean expression: 0.00003), using the multivariate logistic regression. Conclusion: The role of miR-499 in gene expression regulation during hypoxia and our findings indicate that miR-499 could be a new diagnostic biomarker for OSAS.

• MeSH
• biologické markery krev   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• logistické modely MeSH
• mikro RNA genetika   MeSH
• multivariační analýza MeSH
• obstrukční spánková apnoe krev   diagnóza   genetika   MeSH
• polymerázová řetězová reakce s reverzní transkripcí MeSH
• regulace genové exprese MeSH
• ROC křivka MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Akutní infarkt myokardu je jednou z hlavních příčin morbidity a mortality v rozvojových zemích, jako např. v Indii, a dokonce po celém světě. Jeho etiologie je složitá vzhledem k několika zkreslujícím faktorům v jeho patogenezi. V poslední době se prokázalo, že významnou úlohu v predikci diagnózy a prognózy infarktu myokardu hrají malé molekuly RNA, označované jako mikroRNA (miR), z nichž miR-499 hraje zcela zásadní roli v zotavování kardiomyocytů po poranění. Od té doby několik studií identifikovalo několik typů miR spojených s kardiovaskulárními onemocněními; z nich se miR-499 exprimuje hlavně v myokardu. Hlavním cílem naší studie bylo zkoumat úlohu miR-499 v diagnostice AIM. Do studie bylo zařazeno 60 pacientů s AIM ve věku 30 až 60 let a stejný počet kontrolních osob odpovídajícího věku a pohlaví. Zařazení všech účastníků proběhlo na pracovišti terciární péče (Mahatma Gandhi Medical College and Research Institute). Analýza hodnot miR-499 se prováděla metodou RT-PCR, zatímco lipidový profil a hodnoty CK (NAC), CK-MB a srdečních troponinů (pomocí vysoce senzitivní metody) se stanovovaly metodami schválenými IFCC. Pro srovnání průměrných hodnot případů a kontrol byl použit nepárový Studentův test. Vztah mezi hodnotami miR a klasickými markery se zkoumal pomocí Pearsonova korelačního koeficientu. Senzitivita a specificita miR-499 u AIM se hodnotila pomocí vynesené křivky ROC (Receiver Operating Characteristic). Naše studie prokázala statisticky významně vysoké hodnoty miR-499 u pacientů s AMI ve srovnání se zdravými kontrolními osobami (p = 0,012). Hodnoty miR-499 pozitivně korelovaly s hodnotami hs-cnTnT (r = 0,582; p < 0,01) a CK-MB (r = 0,443; p < 0,01). Plocha pod křivkou ROC pro miR-499 měla hodnotu 0,974 se senzitivitou 93,33 % a specificitou 86,67 %; tedy poměrně vyššími než v případě v současnosti používaných markerů CK-MB (86,67 %, resp. 71,67 %) a hs-cnTnT (90,00 %, resp. 81,56 %). Analýza kombinované senzitivity uvedených biomarkerů prokázala, že jejich senzitivita se zvyšuje, zatímco specificita se snižuje. Z výsledků vyplývá, že miR-499 významně koreluje s ostatními klasickými markery při vyšší senzitivitě a specificitě, a mohl by tedy sloužit jako přesnější marker v časné diagnostice AIM.

Acute myocardial infarction is one of the leading causes of morbidity and mortality in developing countries such as India and even worldwide. Its etiology is complicated because of several confounding factors invol-ved in its pathogenesis. Recently, MicroRNA has been recognized to play an important role in predicting the diagnosis and prognosis of myocardial infarction. MiR-499 plays a pivotal role in the recovery of cardiac cell, following injury. Since several studies have profi led several miRs in cardiovascular diseases and of which miR-499 is mainly expressed in the myocardium. Our study is primarily designed to explore the diagnostic role of miR-499 in AMI. The study included 60 AMI patients aged 30–60 years and an equal number of age and gender matched controls. All cases were taken from Mahatma Gandhi Medical College and Research Institute a tertiary healthcare set up and analyzed for miR-499 by RT-PCR, Lipid Profi le, CK (NAC), CK-MB and high sensitivity cardiac Troponin T were analyzed by IFCC approved methods. Unpaired Student’s test was performed to compare the mean of the cases with the controls. Pearson correlation was used to study the association of miR with conventional markers. Receiver Operating Characteristic curve was plotted to fi nd out the sensitivity and specifi city of miR-499 in AMI. Our study showed signifi cantly high levels of miR-499 in AMI patients in comparison to the healthy controls (p = 0.012). MiR-499 levels positively correlated with hs-cnTnT (r = 0.582, p < 0.01) and CK-MB (r = 0.443, p < 0.01). ROC for miR-499 showed an AUC 0.974 with 93.33% sensitivity and 86.67% specifi city which was comparatively higher than the current markers CK-MB (86.67% and 71.67%) and hs-cTnT (90.00% and 81.56%). When these biomarkers analyzed for combined sensitivity increases but the specifi city decreases. The results showed that miR-499 has a signifi cant correlati-on and also had higher sensitivity and specifi city when compared to other conventional markers and thus it could serve as a better early diagnostic marker of AMI.

Background: The evaluation of the long-term risk of major adverse cardiovascular events and cardiac death in patients after acute myocardial infarction (AMI) is an established clinical process. Laboratory markers may significantly help with the risk stratification of these patients. Our objective was to find the relation of selected microRNAs to the standard markers of AMI and determine if these microRNAs can be used to identify patients at increased risk. Methods: Selected microRNAs (miR-1, miR-133a, and miR-499) were measured in a cohort of 122 patients from the PRAGUE-18 study (ticagrelor vs. prasugrel in AMI treated with primary percutaneous coronary intervention (pPCI)). The cohort was split into two subgroups: 116 patients who did not die (survivors) and 6 patients who died (nonsurvivors) during the 365-day period after AMI. Plasma levels of selected circulating miRNAs were then assessed in combination with high-sensitivity cardiac troponin T (hsTnT) and N-terminal probrain natriuretic peptide (NT-proBNP). Results: miR-1, miR-133a, and miR-499 correlated positively with NT-proBNP and hsTnT 24 hours after admission and negatively with left ventricular ejection fraction (LVEF). Both miR-1 and miR-133a positively correlated with hsTnT at admission. Median relative levels of all selected miRNAs were higher in the subgroup of nonsurvivors (N = 6) in comparison with survivors (N = 116), but the difference did not reach statistical significance. All patients in the nonsurvivor subgroup had miR-499 and NT-proBNP levels above the cut-off values (891.5 ng/L for NT-proBNP and 0.088 for miR-499), whereas in the survivor subgroup, only 28.4% of patients were above the cut-off values (p = 0.001). Conclusions: Statistically significant correlation was found between miR-1, miR-133a, and miR-499 and hsTnT, NT-proBNP, and LVEF. In addition, this analysis suggests that plasma levels of circulating miR-499 could contribute to the identification of patients at increased risk of death during the first year after AMI, especially when combined with NT-proBNP levels.

• MeSH
• biologické markery analýza   MeSH
• dospělí MeSH
• infarkt myokardu farmakoterapie   genetika   mortalita   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mikro RNA genetika   MeSH
• míra přežití MeSH
• následné studie MeSH
• prognóza MeSH
• regulace genové exprese u nádorů * MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze IV MeSH
• multicentrická studie MeSH
• randomizované kontrolované studie MeSH

Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, a class of small noncoding RNAs, contribute to basic mechanisms underlying brain development and plasticity, suggesting their possible involvement in the pathogenesis of several psychiatric disorders, including BD. In the present study, gene-based analyses were performed for all known autosomal microRNAs using the largest genome-wide association data set of BD to date (9747 patients and 14 278 controls). Associated and brain-expressed microRNAs were then investigated in target gene and pathway analyses. Functional analyses of miR-499 and miR-708 were performed in rat hippocampal neurons. Ninety-eight of the six hundred nine investigated microRNAs showed nominally significant P-values, suggesting that BD-associated microRNAs might be enriched within known microRNA loci. After correction for multiple testing, nine microRNAs showed a significant association with BD. The most promising were miR-499, miR-708 and miR-1908. Target gene and pathway analyses revealed 18 significant canonical pathways, including brain development and neuron projection. For miR-499, four Bonferroni-corrected significant target genes were identified, including the genome-wide risk gene for psychiatric disorder CACNB2. First results of functional analyses in rat hippocampal neurons neither revealed nor excluded a major contribution of miR-499 or miR-708 to dendritic spine morphogenesis. The present results suggest that research is warranted to elucidate the precise involvement of microRNAs and their downstream pathways in BD.

• MeSH
• bipolární porucha genetika   MeSH
• celogenomová asociační studie statistika a číselné údaje   MeSH
• genetická predispozice k nemoci genetika   MeSH
• krysa rodu rattus MeSH
• lidé MeSH
• mikro RNA genetika   MeSH
• modely nemocí na zvířatech MeSH
• potkani Sprague-Dawley MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

This study aimed to evaluate the ability of selected microRNAs as biomarkers of atrial fibrillation (AF) in ischemic stroke patients in comparison with other established biochemical biomarkers. A prospective case-control study of consecutive ischemic stroke patients with AF admitted to a comprehensive stroke center was conducted. The control group consisted of patients with ischemic stroke with no AF detected on prolonged (at least 3 weeks) Holter ECG monitoring. As potential biomarkers of AF, we analyzed the plasma levels of microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) and 13 biochemical biomarkers at admission. The predictive accuracy of biomarkers was assessed by calculating the area under the receiver operating characteristic curve. The data of 117 patients were analyzed (61 with AF, 56 with no AF, 46% men, median age 73 years, median National Institutes of Health Stroke Scale 6). Biochemical biomarkers (N-terminal pro-B-type natriuretic peptide [NT-proBNP], high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and total triglycerides) were significantly associated with AF. NT-proBNP had the best diagnostic performance for AF with area under the receiver operating characteristic curve 0.92 (95%, CI 0.86-0.98); a cutoff value of >528 ng/L had a sensitivity of 79% and a specificity of 97%. None of the other biomarkers, including microRNAs, was associated with AF. Conventional biochemical biomarkers (NT-proBNP, high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and triglycerides), but not microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) were significantly associated with AF in our ischemic stroke cohort.

• MeSH
• biologické markery * krev   MeSH
• C-reaktivní protein analýza   MeSH
• fibrilace síní * krev   diagnóza   genetika   MeSH
• ischemická cévní mozková příhoda * krev   diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mikro RNA * krev   MeSH
• natriuretický peptid typu B krev   MeSH
• peptidové fragmenty krev   MeSH
• prospektivní studie MeSH
• ROC křivka MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• studie případů a kontrol MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH

A number of microRNAs are involved in the pathophysiological events associated with heart disease. In this review, we discuss miR-21, miR-1, miR-23a, miR-142-5p, miR-126, miR-29, miR-195, and miR-499 because they are most often mentioned as important specific indicators of myocardial hypertrophy and fibrosis leading to heart failure. The clinical use of microRNAs as biomarkers and for therapeutic interventions in cardiovascular diseases appears highly promising. However, there remain many unresolved details regarding their specific actions in distinct pathological phenomena. The introduction of microRNAs into routine practice, as part of the cardiovascular examination panel, will require additional clinically relevant and reliable data. Thus, there remains a need for additional research in this area, as well as the optimization and standardization of laboratory procedures which could significantly shorten the determination time, and make microRNA analysis simpler and more affordable. In this review, we aim to summarize the current knowledge about selected microRNAs related to heart failure, including their potential use in diagnosis, prognosis, and treatment, and options for their laboratory determination.

• MeSH
• biologické markery MeSH
• fibróza MeSH
• lidé MeSH
• mikro RNA * genetika   MeSH
• prognóza MeSH
• srdeční selhání * diagnóza   genetika   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of microRNA action. To test whether they could be involved in daunorubicin-associated cardiomyopathy (DACM), we determined expression patterns of myomiRs in two distinct models of DACM. We used 10-12 weeks old male Wistar rats. In the sub-acute model, rats were administered with six doses of daunorubicin (DAU-A, 3 mg/kg, i.p., every 48 h). Rats were sacrificed two days after the last dose. In the sub-chronic model, anaesthetized rats were administered a single dose of daunorubicin (15 mg/kg, i.v., DAU-C). Age-matched controls (CON) received vehicle. Rats were sacrificed eight weeks later. Left ventricular (LV) functions (LV pressure, rate of pressure development, +dP/dt and decline, -dP/dt) were measured using left ventricular catheterization. Expressions of myomiRs (miR-208a, miR-499, miR-1 and miR-133a), markers of cardiac failure (atrial and brain natriuretic peptides genes; Nppa and Nppb) and myosin heavy chain genes (Myh6, Myh7, Myh7b) in cardiac tissue were determined by RT-PCR. Protein expression of gp91phox NADPH oxidase subunit was detected by immunoblotting. Both DAU groups exhibited a similar depression of LV function, and LV weight reduction, accompanied by an upregulation of natriuretic peptides, and a decrease of Myh6 to total Myh ratio (-18% in DAU-A and - 25% in DAU-C, as compared to controls; both P < 0.05). DAU-C, but not DAU-A rats had a 35% mortality rate and exhibited a significantly increased gp91phox expression (DAU-C: 197 ± 33 versus CON-C: 100 ± 11; P < 0.05). Interestingly, myomiRs levels were only reduced in DAU-C compared to CON-C (miR-208: -45%, miR-499: -30%, miR-1: -29%, miR- and miR133a: -25%; all P < 0.05) but were unaltered in DAU-A. The lack of myomiRs expression, particularly in sub-chronic model, suggests the loss of control of myomiRs network on late progression of DACM. We suppose that the poor inhibition of mRNA targets might contribute to chronic DACM.

• MeSH
• daunomycin škodlivé účinky   farmakologie   MeSH
• down regulace účinky léků   MeSH
• kardiomyopatie chemicky indukované   metabolismus   patologie   patofyziologie   MeSH
• krysa rodu rattus MeSH
• mikro RNA biosyntéza   MeSH
• modely nemocí na zvířatech MeSH
• potkani Wistar MeSH
• svalové proteiny biosyntéza   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

We sought to analyse plasma levels of peripheral blood microRNAs (miRs) as biomarkers of ST-segment-elevation myocardial infarction (STEMI) due to type-1 myocardial infarction as a model situation of vulnerable plaque (VP) rupture. Samples of 20 patients with STEMI were compared both with a group of patients without angina pectoris in whom coronary angiogram did not reveal coronary atherosclerotic disease (no coronary atherosclerosis-NCA) and a group of patients with stable angina pectoris and at least one significant coronary artery stenosis (stable coronary artery disease-SCAD). This study design allowed us to identify miRs deregulated in the setting of acute coronary artery occlusion due to VP rupture. Based on an initial large scale miR assay screening, we selected a total of 12 miRs (three study miRs and nine controls) that were tested in the study. Two of the study miRs (miR-331 and miR-151-3p) significantly distinguished STEMI patients from the control groups, while ROC analysis confirmed their suitability as biomarkers. Importantly, this was observed in patients presenting early with STEMI, even before the markers of myocardial necrosis (cardiac troponin I, miR-208 and miR-499) were elevated, which suggests that the origin of miR-331 and miR-151-3p might be in the VP. In conclusion, the study provides two novel biomarkers observed in STEMI, which may be associated with plaque rupture.

• MeSH
• akutní koronární syndrom genetika   MeSH
• genetické markery genetika   MeSH
• infarkt myokardu s elevacemi ST úseků genetika   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mikro RNA genetika   MeSH
• nemoci koronárních tepen genetika   MeSH
• senioři MeSH
• studie případů a kontrol MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Příspěvek se zaměřuje na analýzu přítomnosti problémů s přizpůsobením u dospívajících z prostředí ústavní péče a srovnání s populací adolescentů, kteří vyrůstali v rodinném prostředí. Výzkum byl realizován u 499 dospívajících (285 z prostředí ústavní péče a 214 z rodinného prostředí) ve věku 13–21. K zjištění přítomnosti problémů s přizpůsobením byl použit dotazník Youth Self Report. Výsledky ukázaly, že dospívající v ústavní péči dosahují ve všech oblastech vyšších průměrných hodnot, tj. projevují větší problémy s přizpůsobením. Také zastoupení jednotlivých diagnostických kategorií pro jednotlivé typy problémů ukazuje větší zastoupení ne–normálních pásem (hraniční, klinické) u dospívajících v ústavní péči, především v rámci hraničního pásma. Největší rozdíly se projevily v dimenzích Problémy s myšlením a dimenzi Porušování norem. MANOVA analýza následně potvrdila existenci signifikantních rozdílů mezi oběma skupinami dospívajících, většina rozdílů ale měla pouze malou sílu. V míře přítomnosti problémů s přizpůsobením se tak obě skupiny až na výše zmíněné dimenze příliš neliší.

Problem: Residential care environment represents a specific social space that is associated with a number of negative consequences, covering most aspects of children and youth functioning. The paper analyzes of the presence of adjustment problems among adolescents from institutional care environment and compares this results with a population of adolescents who grew up in a family. Methods: The sample consisted of two groups of adolescents. The first group included 285 adolescents currently growing up in an residential care environment, aged 13 to 21 (M = 16.23, SD = 1.643). The second group consisted of 214 adolescents growing up in a family, aged 15 to 20 (M = 17.07, SD = 1.070). We used a questionnaire Youth Self Report. Data were analyzed using descriptive statistics and MANOVA. Results: Results showed that adolescents in residential care exhibit higher average values in all adjustment problems. Also, in the context of diagnostic categories are the residential care adolescents more frequently in non-normal range (borderline and clinical), primarily in the border range. The greatest differences were reflected in the Thought problems and Rule-breaking behavior. MANOVA showed a significant multivariate effect between groups of adolescents, Hotelling's T = .803, F(8, 490) = 49.202, p <.001, d = .445 (large effect). Univariate analysis further showed a significant effect for Withdrawn/depressed (p = .044, d = .089, small effect), Somatic complaints (p = .002, d = .139, medium effect), Social problems (p = 004, d = .127, a small effect), Thought problems (p <.001, d = .633, strong effect), Attention problems (p <.001, d = .320,strong effect), Rule-breaking behavior (p <.001 , d = .383, strong effect), and Aggressive behavior (p = 015, d = .110, small effect). Results for the dimension of Anxious/depressed were not significant (p = .159). Discussion: The results didn’t confirmed the assumption that more than 30% of residential care adolescents have adjustment problems in the clinical range. Overall, the results do not correspond with previous findings, which describes more frequent presence of various adjustment problems. More frequently occur only the thought problems and rule-breaking behavior. Hyperactivity and cognitive problems are indicated as typical for residential care children, with wider causes in the emotional development. Problems with rule-breaking behavior have most likely a complex background. MANOVA analysis confirmed the finding that there is a significant difference between groups, but in most cases only with small effect. The residential care environment in the Czech Republic thus can be evaluated as functional, regarding its purpose and function. Conclusion: The results showed the differences in the presence of adjustment problems in adolescents growing up in the family and in institutional care, but also pointed to the fact that these differences are in most cases only small. The current state of the residential care environment in terms of adjustment problems can be evaluated as quite positive.

• Klíčová slova
• citová vazba,
• MeSH
• dětský domov MeSH
• kognice MeSH
• lidé MeSH
• mladiství v ústavní péči * psychologie   MeSH
• mladiství MeSH
• mladý dospělý MeSH
• muži MeSH
• osobnostní dotazník statistika a číselné údaje   MeSH
• průzkumy a dotazníky MeSH
• psychosociální deprivace MeSH
• sociální přizpůsobení * MeSH
• ženy MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH
• srovnávací studie MeSH