- MeSH
- anamnéza metody MeSH
- diagnostické techniky a postupy MeSH
- diagnostické techniky neurologické využití MeSH
- diagnostické techniky otologické využití MeSH
- diferenciální diagnóza MeSH
- dítě MeSH
- elektronystagmografie MeSH
- Friedreichova ataxie diagnóza patofyziologie MeSH
- labyrintitida diagnóza patofyziologie MeSH
- lidé MeSH
- mezioborová komunikace MeSH
- nádory centrálního nervového systému MeSH
- neurootologie metody MeSH
- pediatrie * metody MeSH
- somatosenzorické poruchy diagnóza etiologie MeSH
- statistika jako téma MeSH
- vertigo * diagnóza etiologie MeSH
- vestibulární nemoci * diagnóza etiologie patofyziologie MeSH
- závrať diagnóza etiologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
The most frequent hereditary hearing loss is caused by mutations in the GJB2 gene coding for the gap junction beta 2 protein Connexin 26 (Cx26). In contrast to many studies performed in patients with bi-allelic mutations, audiometric studies on heterozygotes are sparse and often contradictory. To evaluate hearing function in heterozygous carriers of the GJB2 c.35delG mutation, audiometry over the extended frequency range and the recording of otoacoustic emissions (OAEs), i.e., transient-evoked OAEs (TEOAEs) and distortion product OAEs (DPOAEs), were performed in a group of parents and grandparents of deaf children homozygous for the GJB2 c.35delG mutation. The comparison of audiograms between control and heterozygous subjects was enabled using audiogram normalization for age and sex. Hearing loss, estimated with this procedure, was found to be significantly larger in GJB2 c.35delG heterozygous females in comparison with controls for the frequencies of 8-16 kHz; the deterioration of hearing in heterozygous men in comparison with controls was not statistically significant. A comparison of TEOAE responses and DPOAE levels between GJB2 c.35delG heterozygotes and controls did not reveal any significant differences. The results prove the importance of using audiometry over the extended frequency range and audiogram normalization for age and sex to detect minor hearing impairments, even in a relatively small group of subjects of different ages.
- MeSH
- dospělí MeSH
- genetická predispozice k nemoci genetika MeSH
- genetické markery genetika MeSH
- heterozygot * MeSH
- incidence MeSH
- jednonukleotidový polymorfismus genetika MeSH
- konexiny genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace genetika MeSH
- percepční nedoslýchavost diagnóza epidemiologie patofyziologie MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sluchové testy statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Pediatrie pro praxi Medicína pro praxi Dobrá rada pro pacienta
Vyd. 1. 26 s. : il. ; 21 cm
Informační brožura o kašli, rýmě, zánětech horních cest dýchacích a chřipce.
- MeSH
- chřipka lidská farmakoterapie komplikace prevence a kontrola MeSH
- faryngitida MeSH
- imunita MeSH
- kašel etiologie farmakoterapie klasifikace MeSH
- laryngitida farmakoterapie MeSH
- rýma farmakoterapie klasifikace prevence a kontrola MeSH
- Publikační typ
- populární práce MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- pneumologie a ftizeologie
- otorinolaryngologie
- NLK Publikační typ
- informační publikace
With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range of 125 Hz-12.5 kHz were similar in all age groups, the average hearing threshold at 16 kHz was significantly elevated in the oldest age group. The response values of transiently evoked otoacoustic emissions (TEOAEs) significantly declined with age; the decline was negatively correlated with the hearing loss at 16 kHz. Significantly larger TEOAE responses and average distortion-product otoacoustic emission (DPOAE) values at 6.3 kHz were present in the youngest group in comparison with the other three older groups. Spontaneous otoacoustic emissions (SOAEs) were present in 70.8% of the children (in either one or both ears) with the greatest prevalence in the 11-20-year-old subjects. In the 21-25-year-old group, the hearing loss at 16 kHz was significantly smaller in ears with SOAEs than in ears without SOAEs. The results demonstrate that the increase in the high frequency hearing threshold at 16 kHz, which starts at ages over 20 years, is correlated with a decrease in the TEOAE responses at middle frequencies.
- MeSH
- akustické impedanční testy MeSH
- audiometrie čistými tóny MeSH
- dítě MeSH
- dospělí MeSH
- financování organizované MeSH
- kochlea fyziologie MeSH
- lidé MeSH
- mladiství MeSH
- otoakustické emise spontánní fyziologie MeSH
- otoskopie MeSH
- sluchový práh fyziologie MeSH
- věkové faktory MeSH
- vnímání výšky zvuku fyziologie MeSH
- vysokofrekvenční nedoslýchavost patofyziologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
