• MeSH
• Walking * MeSH
• Adult MeSH
• Cardiovascular Diseases prevention & control   MeSH
• Clinical Laboratory Techniques methods   MeSH
• Quality of Life MeSH
• Humans MeSH
• Nordic Walking MeSH
• Dependent Ambulation MeSH
• Motor Activity * MeSH
• Healthy People Programs MeSH
• Surveys and Questionnaires MeSH
• Rehabilitation methods   MeSH
• Schizophrenia * complications   rehabilitation   MeSH
• Diet, Food, and Nutrition MeSH
• Physical Fitness MeSH
• Exercise Therapy methods   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Case Reports MeSH

Techniques to quantify postural stability usually rely on the evaluation of only two variables, that is, two coordinates of COP. However, by using three variables, that is, three components of acceleration vector, it is possible to describe human movement more precisely. For this purpose, a single three-axis accelerometer was used, making it possible to evaluate 3D movement by use of a novel method, convex polyhedron (CP), together with a traditional method, based on area of the confidence ellipse (ACE). Ten patients (Pts) with cerebellar ataxia and eleven healthy individuals of control group (CG) participated in the study. The results show a significant increase of volume of the CP (CPV) in Pts or CG standing on foam surface with eyes open (EO) and eyes closed (EC) after the EC phase. Significant difference between Pts and CG was found in all cases as well. Correlation coefficient indicates strong correlation between the CPV and ACE in most cases of patient examinations, thus confirming the possibility of quantification of postural instability by the introduced method of CPV.

• MeSH
• Accelerometry methods   MeSH
• Adult MeSH
• Humans MeSH
• Posture physiology   MeSH
• Postural Balance physiology   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• Publication type
• Meeting Abstract MeSH

• Publication type
• Meeting Abstract MeSH

UNLABELLED: Syringomyelia is characterized by cavity formation in the spinal cord, most often at C2-Th9 level. Clinical manifestation reflects extent and localization of the spinal cord injury. CASES: 20-year old woman was admitted for recurrent rest-related presyncopes with sudden manifestation. Paroxysms of sinus bradycardia with SA and AV blocks were repeatedly documented during symptoms. There was normal echocardiographic finding, (para) infectious etiology was not proved. Character of the ECG findings raised suspicion on neurogenic cause. Autonomic nervous system testing demonstrated abnormalities reflecting predominant sympathetic dysfunction. Suspicion on incipient myelopathy was subsequently confirmed by MRI, which discovered syringomyelia at Th5 level as the only pathology. A 52-year old man with hypotrophic quadruparesis resulting from perinatal brain injury was sent for 2-years lasting symptoms (sudden palpitation, sweating, muscle tightness, shaking) with progressive worsening. Symptoms occurred in association with sudden increase of sinus rhythm rate and blood pressure that were provoked by minimal physical activity. Presence of significant autonomic dysregulation with baroreflex hyperreactivity in orthostatic test and symptomatic postural orthostatic tachycardia with verticalization-associated hypertension were proved. MRI revealed syringomyelia at C7 and Th7 level affecting sympathetic centers at these levels. Sympathetic fibers dysfunction at C-Th spinal level may cause significant autonomic dysfunction with arrhythmic manifestation.

• MeSH
• Diagnosis, Differential MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Autonomic Nervous System Diseases diagnosis   etiology   prevention & control   MeSH
• Arrhythmias, Cardiac diagnosis   etiology   prevention & control   MeSH
• Syringomyelia complications   diagnosis   therapy   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Letter MeSH
• Case Reports MeSH

OBJECTIVE: Lumbar facet joints (FJ) is a common source of low back pain and contributes approximmately on one third of chronic low back pain. Medial branch radiofrequency neurotomy is considered as a gold standard in the treatment of facet joint pain. Corticosteroid injections have also presented effect in FJ pain. As an interventional procedures, they carry not-negligible risk of possible complications including infection, damage to nerve root or medial branch structures. Shockwave therapy (SWT) is a non-invasive method for treatment of various musculoskeletal disorders. Its effect is based on transduction of mechanical energy, transferred to cascade of various biochemical processes in target tissue. Its efficacy was proved in the treatment of different painful conditions. The efficacy of SWT was not yet studied in FJ pain. Aim of our work was to compare the efficacy of SWT against interventional treatment procedures - radiofrequency neurotomy and corticosteroid FJ injections. METHODS: A retrospective study was done on 62 selected patients with unilateral chronic lumbar facet pain. There were 32 women and 30 men, divided into SWT group, corticosteroid injections group radiofrequency group. Nociceptive and neuropathic pain intensity and severity of pain were measured. RESULTS: Shockwave therapy had shown better longterm results compared to FJ injections group and little inferior efficacy compared to RMBN. We did not observe any adverse effects and complications in SWT group. Moreover, in SWT and RMBN groups, significant longterm improvement in daily activities limitation, was observed. CONCLUSIONS: SWT appears to be a safe and perspective option in the treatment of FJ pain with negligible side effects.

• MeSH
• Arthralgia * drug therapy   surgery   ultrasonography   MeSH
• Lumbar Vertebrae drug effects   innervation   ultrasonography   MeSH
• Mechanotransduction, Cellular physiology   MeSH
• Denervation methods   MeSH
• Adrenal Cortex Hormones therapeutic use   MeSH
• Combined Modality Therapy MeSH
• Humans MeSH
• Low Back Pain * drug therapy   surgery   ultrasonography   MeSH
• Zygapophyseal Joint drug effects   innervation   ultrastructure   MeSH
• Pilot Projects MeSH
• High-Energy Shock Waves therapeutic use   MeSH
• Retrospective Studies MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

• MeSH
• Autonomic Nervous System physiopathology   MeSH
• Models, Biological * MeSH
• Early Diagnosis MeSH
• Cardiovascular Diseases * diagnosis   MeSH
• Humans MeSH
• Models, Cardiovascular MeSH
• Nonlinear Dynamics * MeSH
• Heart Rate physiology   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

Úvod: Práce pojednává o využití rekurentní analýzy variability srdeční frekvence (RQA) v časné diagnostice diabetické autonomní neuropatie. Kardiovaskulární forma diabetické neuropatie je nejzávažnější autonomní komplikací diabetu typu 1 i 2 s vysokou morbiditou a mortalitou. V diagnostice diabetické autonomní neuropatie se uplatňují funkční testy vyšetřující dynamiku kardiovaskulárního systému při vertikalizaci a během dechových testů. Záznam RR intervalů je analyzován v časové a frekvenční doméně (spektrální analýza), stále častěji se však užívají metody nelineární analýzy schopné lépe popsat systém nadřazené kontroly srdečního rytmu. Mezi metody nelineární analýzy řadíme i RQA. Metodika: Použili jsme RQA při ortostatickém testu (leh-stoj) u skupiny 20 kompenzovaných diabetiků 2. typu ve věku 50–62 let bez příznaků autonomní neuropatie. Hodnoceny byly čtyři proměnné RQA – determinizmus, laminarita, Lmax a trapping time. Výsledky byly srovnány s věkově odpovídající skupinou 20 zdravých kontrol. Výsledky: Byly prokázány signifikantní rozdíly proměnných determinizmus (p < 0,0001), laminarita (p < 0,0002), nejdelší diagonální čáry Lmax (p = 0,026) a průměrné délky vertikálních čar trapping time (p = 0,0214) mezi skupinami. Následně byly srovnány vybrané proměnné rekurentní, časové a spektrální analýzy v obou fázích ortostatické zkoušky. Závěr: Při porovnání proměnných rekurentní analýzy u diabetiků a kontrol byly zjištěny signifikantní rozdíly mezi oběma skupinami, svědčící pro vyšší rekurenci RR intervalů a simplifikaci záznamu variability srdeční frekvence u diabetiků. Při vzájemném porovnání statistické hladiny významnosti vybraných proměnných analýzy bylo zjištěno, že RQA disponuje velmi vysokou senzitivitou. RQA by proto mohla být přínosným doplňkem k rutinně užívaným metodám analýzy RR intervalů při funkčním vyšetření autonomního nervového systému.

Introduction: Detection of autonomic dysfunction in subclinical stages of diabetic cardiovascular autonomic neuropathy is highly important and helps in therapeutic management. Evaluation of cardiovascular function is usually based on heart rate variability (HRV) linear data analysis in time and frequency domains. However, autonomic control of heart rate is complex and could be described by non-linear analysis. In our study, non-linear recurrence quantification analysis (RQA) was used. Methods: We analyzed RQA during orthostatic test in 20 patients with type 2 diabetes (mean age 54 years). Results were compared to sex and age-matched group of 20 healthy controls (mean age 53 years). Cross-comparison between RQA, time- and frequency-domains analysis during the supine rest phase of orthostatic test was also performed. Results: There was significant increase in percentage of recurrences in diabetic patients compared to controls in the following variables: determinism (p <0.0001), laminarity (p <0.0002), length of the longest diagonal line Lmax (p = 0.026) and mean length of vertical lines trapping time (p = 0.0214) in both phases of the orthostatic test. We found significant increase in determinism, laminarity and trapping time in the supine rest phase. However, the Lmax parameter remained insignificant compared to the control group and results were similar to previous studies. Conclusion: Reduction of complexity in cardiovascular regulation was found in diabetic patients compared to age-matched controls. In comparison to standard methods, RQA appears to be more sensitive in diagnostics of subclinical cardiovascular autonomic neuropathy. RQA may be useful as an additional approach to time and frequency domain analysis of HRV. Key words: diabetic autonomic neuropathy – cardiac autonomic neuropathy – diabetes mellitus – heart rate variability – spectral analysis – recurrence analysis

• Keywords
• diabetická autonomní neuropatie, variabilita srdeční frekvence, kardiální autonomní neuropatie,
• MeSH
• Early Diagnosis MeSH
• Diabetes Mellitus, Type 2 complications   MeSH
• Diabetes Mellitus MeSH
• Diabetic Neuropathies * diagnosis   epidemiology   complications   MeSH
• Diagnosis, Computer-Assisted MeSH
• Electrocardiography statistics & numerical data   MeSH
• Data Interpretation, Statistical MeSH
• Cardiovascular Diseases diagnosis   epidemiology   complications   MeSH
• Middle Aged MeSH
• Humans MeSH
• Models, Cardiovascular * MeSH
• Nonlinear Dynamics MeSH
• Periodicity MeSH
• Pilot Projects MeSH
• Posture MeSH
• Reproducibility of Results MeSH
• Sensitivity and Specificity MeSH
• Spectrum Analysis statistics & numerical data   MeSH
• Heart Rate * physiology   MeSH
• Statistics as Topic MeSH
• Case-Control Studies MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Evaluation Study MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Biophysics MeSH

• Conspectus
• Biochemie. Molekulární biologie. Biofyzika
• Učební osnovy. Vyučovací předměty. Učebnice
• NML Fields
• fyzika, biofyzika
• NML Publication type
• učebnice vysokých škol
• praktická cvičení

Chronická bolest bederní páteře (CBBP) sužuje v civilizovaných zemích až 10 % populace. Etiologie CBBP je komplexní, zahrnuje strukturální změny skeletu páteře, meziobratlové ploténky a okolních měkkých tkání, významné jsou též vlivy psychosociální. Z hlediska je CBBP bolestí smíšenou s uplatněním nociceptivních i neuropatických vlivů. Neuropatická komponenta postihuje až třetinu pacientů s CBBP, může se projevovat charakteristickou iradiací do končetiny (radikulární neuropatická CBBP) či neuropatickými projevy v bederní oblasti (lokální neuropatická bolest). Práce pojednává o anatomických a patofyziologických souvislostech relevantních pro rozvoj neuropatické bolesti u CBBP a možnostech její diagnostiky a terapie.

Chronic low back pain (CBBP) is a common symptom affecting around 10 % of adult population in Western societies. Neuropathic component is common, affecting around 1/3 of CBBP patients. It consists of local neuropathic pain within the degenerated intervertebral disc and surrounding soft tissues as well as radicular pain which is caused by local nerve root compression, swelling or inflamation. Clinical manifestation of neuropathic low back pain depends on affected nerve structures. Compression of nerve root or ventral rami of spinal nerve usually causes sciatica. Symptoms of local neuropathic pain vary from latent trigger points or segmental tenderness (myofascial pain syndrome) to abnormal skin sensations within the low back area. Presence of neuropathic pain has important impact upon analgetic treatment, first line non-steroid antiflogistics (NSA) are effective in nociceptive pain only and does not have significant effect on neuropathic component. Adjunct of tricyclic antidepressants, 3rd generation anticonvulsants such as pregabaline or gabapentine or local anesthetic/steroid blocks can be beneficial in patients who do not respond to NSA in monotherapy. Non-pharmacotherapeutical procedures – manipulation techniques, back school, physical therapy, accupuncture or psychotherapy are no less effective therapeutic approaches, that can be used for complex treatment of chronic low back pain.

• Keywords
• degenerativní onemocnění páteře, neuropatická bolest,
• MeSH
• Pain physiopathology   MeSH
• Chronic Disease MeSH
• Diagnosis, Differential MeSH
• Drug Therapy methods   trends   MeSH
• Financing, Organized MeSH
• Humans MeSH
• Low Back Pain etiology   physiopathology   therapy   MeSH
• Pain Measurement MeSH
• Intervertebral Disc physiopathology   MeSH
• Spinal Diseases diagnosis   etiology   therapy   MeSH
• Neural Pathways physiopathology   pathology   MeSH
• Neuralgia drug therapy   complications   therapy   MeSH
• Neuronal Plasticity MeSH
• Neurotransmitter Agents therapeutic use   MeSH
• Nociceptors physiology   MeSH
• Signs and Symptoms MeSH
• Exercise Therapy MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH