První vydání 143 stran : ilustrace (převážně barevné), portréty ; 22 cm
Příručka, která se zaměřuje na léčbu nemocí a bolesti kloubů pomocí tradičních aplských metod. Autor popisuje své zkušenosti. Určeno odborné i široké veřejnosti.
- MeSH
- artralgie MeSH
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- dějiny lékařství MeSH
- management bolesti MeSH
- muskuloskeletální manipulace MeSH
- nemoci kloubů * MeSH
- tradiční lékařství MeSH
- Check Tag
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- Publikační typ
- osobní vyprávění MeSH
- populární práce MeSH
- příručky MeSH
- Geografické názvy
- alpské země MeSH
- Konspekt
- Fyzioterapie. Psychoterapie. Alternativní lékařství
- Biografie
- NLK Obory
- ortopedie
- alternativní lékařství
- O autorovi
- Karsch, Klaus, 1946- Autorita
BACKGROUND: The presence of ACPA significantly increases the risk of developing RA. Dysregulation of lymphocyte subpopulations was previously described in RA. Our objective was to propose the predictive model for progression to clinical arthritis based on peripheral lymphocyte subsets and ACPA in individuals who are at risk of RA. METHODS: Our study included 207 at-risk individuals defined by the presence of arthralgias and either additional ACPA positivity or meeting the EULAR definition for clinically suspect arthralgia. For the construction of predictive models, 153 individuals with symptom duration ≥12 months who have not yet progressed to arthritis were included. The lymphocyte subsets were evaluated using flow cytometry and anti-CCP using ELISA. RESULTS: Out of all individuals with arthralgia, 41 progressed to arthritis. A logistic regression model with baseline peripheral blood lymphocyte subpopulations and ACPA as predictors was constructed. The resulting predictive model showed that high anti-CCP IgG, higher percentage of CD4+ T cells, and lower percentage of T and NK cells increased the probability of arthritis development. Moreover, the proposed classification decision tree showed that individuals having both high anti-CCP IgG and low NK cells have the highest risk of developing arthritis. CONCLUSIONS: We propose a predictive model based on baseline levels of lymphocyte subpopulations and ACPA to identify individuals with arthralgia with the highest risk of progression to clinical arthritis. The final model includes T cells and NK cells, which are involved in the pathogenesis of RA. This preliminary model requires further validation in larger at-risk cohorts.
- MeSH
- artralgie * imunologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- podskupiny lymfocytů * imunologie MeSH
- prediktivní hodnota testů MeSH
- progrese nemoci * MeSH
- protilátky proti citrulinovaným peptidům * krev imunologie MeSH
- revmatoidní artritida * imunologie krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
2., přepracované a doplněné vydání (1. v Grada Publishing, a.s.) x, 389 stran : ilustrace ; 26 cm
Publikace se zaměřuje na diferenciální diagnostiku kloubních bolestí. Určeno odborné veřejnosti.
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- ortopedie
- NLK Publikační typ
- kolektivní monografie
Intraoseální ganglion je relativně zřídkavou příčinou chronické bolesti zápěstí. Nejčastěji ganglia nacházíme v os lunatum a os scaphoideum. V mnoha případech je jejich součástí i extraoseální složka, přičemž obě části mohou být zdrojem klinických potíží. V naší kazuistice prezentujeme pacientku s atypickou chronickou bolestí volární části zápěstí, u které byl diagnostikován intraoseální ganglion os scaphoideum s volární extraoseální složkou jakožto hlavním zdrojem potíží. U pacientky byly odstraněny obě složky ganglia a defekt v os scaphoideum byl vyplněn spongioplastikou, což vedlo k vymizení klinických obtíží a eliminaci rizika fraktury os scaphoideum. V práci je popisována a diskutována diagnostická a terapeutická rozvaha u pacientů s nálezem intraoseálních a extraoseálních ganglií zápěstí v návaznosti na relevantní literaturu.
Intraosseous ganglion is a relatively rare cause of chronic wrist pain. The ganglion is most commonly found in the os lunatum and os scaphoideum and in many cases includes an extraosseous component, both of which can be a source of clinical difficulty. In our case report, we present a patient with atypical chronic volar wrist pain who was diagnosed to have an intraosseous ganglion of the os scaphoideum with a volar extraosseous component as the main source of her problems. The patient had both components of the ganglion removed and the defect in the os scaphoideum was filled with an autogenous cancellous bone graft resulting in resolution of the clinical complaints and elimination of the risk of os scaphoideum fracture. The diagnostic and therapeutic considerations in patients found to have an intraosseous ganglion of the wrist with an extraosseous component are described and discussed in relation to the relevant literature.
- MeSH
- artralgie diagnóza terapie MeSH
- člunkovitá kost * chirurgie patologie MeSH
- cystická ganglia * chirurgie diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- zápěstní kloub chirurgie diagnostické zobrazování patofyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Najčastejším symptomatickým prejavom syndrómu iliotibiálneho traktu (ITBS – iliotibial band syndrome) je bolesť bočnej časti kolena, ktorá je spojená s opakovanými pohybovými aktivitami. Pacienti bolesť často udávajú ako bodavú v oblasti okolo laterálneho femorálneho epikondylu, ktorá môže vyžarovať dole iliotibiálnym smerom do holennej kosti. V proximálnej časti stehna dostáva iliotibiálny trakt (ITB) fasciálne časti z hlbokej fascie stehna, m. gluteus maximus a m. tensor fasciae latae. ITBS sa vo väčšine prípadov úspešne lieči neoperačným manažmentom, hoci niekedy je potrebný chirurgický zákrok. Etiológia ITBS je predmetom kontroverzných diskusií. Pre ITBS bolo navrhnutých niekoľko etiológií, vrátane trenia ITB o laterálny femorálny epikondyl, kompresie tukového tkaniva a spojivového tkaniva a chronický zápal burzy ITB. ITBS je diagnóza založená na klinickom prejave. Dôležitým nálezom pri klinickom vyšetrení je lokálna citlivosť laterálnej časti kolena pod epikondylom a nad kĺbovou líniou. Rehabilitácia u pacientov so ITBS predstavuje dôležitú časť komplexnej liečby, ktorá zohráva kľúčovú úlohu pri liečbe ITBS.
Summary: The most common symptomatic manifestation of iliotibial band syndrome (ITBS) includes pain in the lateral part of the knee, which is associated with repetitive movement activities. Patients often describe pain in the area around the lateral femoral epicondyle, which can radiate down the iliotibial direction into the tibia. In the proximal part of the thigh, the iliotibial tract (ITB) receives fascial parts from the deep fascia of the thigh, gluteus maximus, and tensor fasciae latae. ITBS is often successfully treated with non-operative management, although surgery is sometimes required. The etiology of ITBS has been the subject of controversial discussions. Various etiologies have been proposed for ITBS, including friction of the ITB against the lateral femoral epicondyle, compression of the adipose tissue and the connective tissue, and chronic inflammation of the ITB bursa. ITBS is a diagnosis based on clinical presentation. Local tenderness of the lateral part of the knee below the epicondyle and above the joint line is an important finding during physical examination. Rehabilitation in patients with ITBS is an important part of comprehensive treatment that plays a key role in the therapy of ITBS.
BACKGROUND: Individuals with anti-citrullinated protein antibodies (ACPAs) and subclinical inflammatory changes in joints are at high risk of developing rheumatoid arthritis. Treatment strategies to intercept this pre-stage clinical disease remain to be developed. We aimed to assess whether 6-month treatment with abatacept improves inflammation in preclinical rheumatoid arthritis. METHODS: The abatacept reversing subclinical inflammation as measured by MRI in ACPA positive arthralgia (ARIAA) study is a randomised, international, multicentre, double-blind, placebo-controlled trial done in 14 hospitals and community centres across Europe (11 in Germany, two in Spain, and one in the Czech Republic). Adults (aged ≥18 years) with ACPA positivity, joint pain (but no swelling), and signs of osteitis, synovitis, or tenosynovitis in hand MRI were randomly assigned (1:1) to weekly subcutaneous abatacept 125 mg or placebo for 6 months followed by a double-blind, drug-free, observation phase for 12 months. The primary outcome was the proportion of participants with any reduction in inflammatory MRI lesions at 6 months. The primary efficacy analysis was done in the modified intention-to-treat population, which included participants who were randomly assigned and received study medication. Safety analyses were conducted in participants who received the study medication and had at least one post-baseline observation. The study was registered with the EUDRA-CT (2014-000555-93). FINDINGS: Between Nov 6, 2014, and June 15, 2021, 139 participants were screened. Of 100 participants, 50 were randomly assigned to abatacept 125 mg and 50 to placebo. Two participants (one from each group) were excluded due to administration failure or refusing treatment; thus, 98 were included in the modified intention-to-treat population. 70 (71%) of 98 participants were female and 28 (29%) of 98 were male. At 6 months, 28 (57%) of 49 participants in the abatacept group and 15 (31%) of 49 participants in the placebo group showed improvement in MRI subclinical inflammation (absolute difference 26·5%, 95% CI 5·9-45·6; p=0·014). Four (8%) of 49 participants in the abatacept group and 17 (35%) of 49 participants in the placebo group developed rheumatoid arthritis (hazard ratio [HR] 0·14 [0·04-0·47]; p=0·0016). Improvement of MRI inflammation (25 [51%] of 49 participants in the abatacept group, 12 [24%] of 49 in the placebo group; p=0·012) and progression to rheumatoid arthritis (17 [35%] of 49, 28 [57%] of 49; HR 0·14 [0·04-0·47]; p=0·018) remained significantly different between the two groups after 18 months, 12 months after the end of the intervention. There were 12 serious adverse events in 11 participants (four [8%] of 48 in the abatacept group and 7 [14%] of 49 in the placebo group). No deaths occurred during the study. INTERPRETATION: 6-month treatment with abatacept decreases MRI inflammation, clinical symptoms, and risk of rheumatoid arthritis development in participants at high risk. The effects of the intervention persist through a 1-year drug-free observation phase. FUNDING: Innovative Medicine Initiative.
- MeSH
- abatacept škodlivé účinky MeSH
- antirevmatika * škodlivé účinky MeSH
- artralgie chemicky indukované MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- revmatoidní artritida * diagnostické zobrazování farmakoterapie MeSH
- výsledek terapie MeSH
- zánět farmakoterapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- randomizované kontrolované studie MeSH
53 stran : ilustrace ; 20 cm
Příručka se zaměřuje na rehabilitační cvičení k terapii bolestí zad, páteře a kloubů. Určeno široké veřejnosti.
Přehledná část článku je věnována diferenciální diagnostice artralgií a artritid s důrazem na infekční etiologii. Jsou shrnuty základní přístupy k diagnostice artritid u dětských revmatických onemocnění v ambulanci dětské revmatologie a také možnosti, jak k tomuto postupu mohou přispět praktičtí lékaři pro děti a dorost (PLDD). Přinášíme kazuistiky dětských pacientů s artritidou provázející revmatická onemocnění. Artritida může být prvním projevem juvenilní idiopatické artritidy (JIA), systémového lupus erythematodes (SLE), IgA vaskulitidy a mnoha dalších revmatických nemocí, nebo se vyvine v jejich průběhu. Časná diagnóza je klíčem k úspěšné léčbě.
An article is focused on differential diagnosis of arthralgias and arthritides with stress on infectious etiology. We review basic attitudes in diagnostics of pediatric rheumatic diseases and how general practitioners might contribute. Case reports of children with arthritis as a symptom of pediatric rheumatic diseases are described. The arthritis might be the first symptom of juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE), IgA vasculitis and many other rheumatic diseases, or it develops during the disease course. An early diagnosis is a clue to successful therapy.
- MeSH
- artralgie * etiologie MeSH
- artritida * farmakoterapie klasifikace patofyziologie MeSH
- diferenciální diagnóza MeSH
- dítě MeSH
- IgA vaskulitida diagnóza farmakoterapie komplikace MeSH
- infekční artritida etiologie farmakoterapie patologie MeSH
- juvenilní artritida diagnóza farmakoterapie patofyziologie MeSH
- lidé MeSH
- mladiství MeSH
- nefritida při lupus erythematodes diagnóza farmakoterapie komplikace MeSH
- systémový lupus erythematodes farmakoterapie komplikace MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- práce podpořená grantem MeSH
1. vydání 127 stran : barevné ilustrace ; 20 cm
Příručka, která se zaměřuje na léčbu zranění a bolesti kloubů (zejména kolenního a menisku) pomocí rehabilitačních cvičení. Určeno široké veřejnosti.
PURPOSE OF THE STUDY The aim of this study is to confirm that the involvement of arthroscopy in the surgical treatment of painful elbow syndrome, when proper and long enough conservative treatment failed, has better results than open radial epicondylitis surgery alone. MATERIAL AND METHODS A total of 144 patients included 65 men and 79 women, with the mean age of 45.3 years, namely 44.4 years (range 18-61 years) in men and 45.8 years (range 18-60 years) in women. Each patient was clinically examined, an anteroposterior and lateral X-ray of the elbow were performed, and proper therapy was chosen - either primary diagnostic and therapeutic arthroscopy followed by open epicondylitis surgery or primary open epicondylitis surgery alone. The treatment effect was evaluated by using the QuickDASH (Disabilities of the Arm, Shoulder and Hand) scoring system at 6 months after surgery. RESULTS Out of the total group of 144 patients, 114 (79%) patients completed the questionnaire. All the results of the QuickDASH score in our group of patients are in the better half (0-5 very good, 6-15 good, 16-35 satisfactory, over 35 poor), with the mean value 5.63 (in men the mean value was 2.95-2.27 for the combination of arthroscopic and open procedure of LE, 4.55 for open procedure of LE, while in women the mean value was 7.50-6.82 for the combination of arthroscopic and open procedure of LE, 9.09 for open procedure of LE only). Altogether 96 patients (72%) experienced full pain relief. In patients treated with a combination of arthroscopic and open surgery, a higher percentage of patients reported full relief (53 patients, 85%) compared to the patients treated with the open method alone (21 patients, 62%). DISCUSSION By involving arthroscopy in the surgical treatment of patients with lateral elbow pain syndrome after unsuccessful conservative treatment, a successful and early solution to the problem was achieved in 72% of patients. The advantage of elbow arthroscopy over the conventional approach to the treatment of lateral epicondylitis consists mainly in the opportunity to observe intraarticular structures, thus provide a detailed view of the entire joint without the need for direct extensive joint opening, which makes it possible to exclude other causes of problems (e. g. chondromalacia of the radial head, loose body and other intraarticular abnormalities). At the same time, we can treat this source of problems with minimum burden placed on the patient. CONCLUSIONS Arthroscopic examination of the elbow joint makes it possible to diagnose all potential intraarticular sources of difficulties. Simultaneous elbow arthroscopy and open treatment of radial epicondylitis (release of ECRB or EDC, ECU, necrotic tissue excision, deperiostation and radial epicondyle microfractures) is a safe method with low morbidity, faster rehabilitation and return to the original activities based on subjective evaluation of patients and objective scoring. Key words: lateral epicondylitis, radiohumeral plica, elbow arthroscopy.
- MeSH
- artralgie MeSH
- artroskopie metody MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- loketní kloub * chirurgie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- radius MeSH
- tenisový loket * chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH