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Article

Allogeneic stem cell transplantation can improve outcome of AML patients without complete cytogenetic response after induction and consolidation treatment

Dvořák, Pavel
Author Dvořák, Pavel Institute of Medical Genetics, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic Institute of Biology, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic
Lysák, Daniel
Author Authority ORCID Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech Republic
Vokurka, Samuel
Author Authority ORCID Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech Republic
Karas, Michal
Author Authority Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech Republic
Subrt, I
Author Subrt, I Institute of Medical Genetics, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic

Neoplasma. 2015 ; 62 (1) : 140-145.

ISSN 0028-2685
Medvik
Source

Keywords
kompletní cytogenetická remise, kompletní morfologická remise,
MeSH
Abnormal Karyotype MeSH
Leukemia, Myeloid, Acute * diagnosis complications mortality therapy MeSH
Chromosome Aberrations * MeSH
Cytarabine therapeutic use MeSH
Adult MeSH
Remission Induction MeSH
Middle Aged MeSH
Humans MeSH
Survival Rate MeSH
Mitoxantrone therapeutic use MeSH
Prognosis MeSH
Antineoplastic Agents classification therapeutic use MeSH
Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
Retrospective Studies MeSH
Aged MeSH
Stem Cell Transplantation * MeSH
Treatment Outcome MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Research Support, Non-U.S. Gov't MeSH
Comparative Study MeSH

Online article

The association of factor V Leiden with various clinical patterns of venous thromboembolism-the factor V Leiden paradox

QJM. 2014 ; 107 (9) : 715-20.

ISSN 1460-2393
Medvik
Source

BACKGROUND: Factor V Leiden (FVL) supposedly carries relatively higher risk of deep vein thrombosis (DVT), compared to the risk of pulmonary embolism (PE). AIM: To prove this paradox in a group of patients with various clinical presentation of venous thromboembolism (VTE). MATERIALS AND METHODS: We retrospectively evaluated clinical pattern of VTE in patients who had been referred to vascular clinic shortly after an acute VTE event. In FVL positive and FVL negative groups we compared the prevalence of isolated symptomatic DVT (proximal or distal) and symptomatic PE with/without DVT, and, moreover, asymptomatic DVT or PE. RESULTS: Of 575 patients (mean age 57 years, 50.1% women), 120 were FVL positive and those had significantly higher prevalence of isolated symptomatic DVT, compared to symptomatic PE with/without DVT. Proximal DVT location was significantly more frequent in FVL carriers. The prevalence of asymptomatic PE did not differ between the two groups. The rate of asymptomatic DVT tended to be higher in FVL negative group. In a multivariate analysis, we confirmed FVL to be positively associated with isolated DVT presentation (odds ratio OR 1.757; 95% confidence interval (CI) 1.148-2.690). On the contrary, increasing age and unprovoked nature of VTE event carried a higher risk of symptomatic PE. CONCLUSIONS: We confirmed FVL to be significantly associated with isolated symptomatic DVT despite higher prevalence of proximal DVT in FVL carriers. The fact of relatively lower risk of PE in FVL positive patients might have clinical implication. However, mechanisms of FVL paradox remain to be elucidated.

MeSH
Asymptomatic Diseases epidemiology MeSH
Point Mutation MeSH
Genetic Carrier Screening MeSH
Adult MeSH
Factor V genetics MeSH
Blood Coagulation genetics MeSH
Middle Aged MeSH
Humans MeSH
Pulmonary Embolism * epidemiology genetics physiopathology MeSH
Prevalence MeSH
Retrospective Studies MeSH
Aged MeSH
Venous Thrombosis * epidemiology genetics physiopathology MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Comparative Study MeSH
Geographicals
Ireland MeSH

Article

Deep vein thrombosis and/or pulmonary embolism concurrent with superficial vein thrombosis of the legs: cross-sectional single center study of prevalence and risk factors

International angiology. 2013 ; 32 (4) : 410-6.

Int Angiol
ISSN 1827-1839
Medvik
Source

AIM: The aim of this paper was to assess the prevalence of concurrent deep vein thrombosis (DVT) and/or pulmonary embolism (PE) in the patients with superficial vein thrombosis (SVT) of the legs and to find factors significantly and independently associated with coincident DVT/PE. METHODS: In the setting of a tertiary referral hospital, patients with SVT, attending vascular clinic, underwent physical examination, laboratory testing and leg vein ultrasound (in the case of clinically suspected PE also perfusion/ventilation lung scan or/and helical CT pulmonary angiography). In statistical analysis, we used unpaired t-test, non-parametric Wilcoxon rank sum test, stepwise logistic regression and multivariable logistic regression model. RESULTS: We examined 138 patients (age 61.4 ± 13.9 years, 36.2% men), with ST mostly on varicose veins (89.9%). The prevalence of concurrent DVT/PE was 34.1%. Neither the clinical manifestation nor SVT localization differed significantly between the group with isolated SVT and that with coincident DVT/PE. Of all the assessed patients characteristics (age and sex, BMI, history of SVT, DVT or PE, hypercoagulable states, cardiovascular risk factors) only two factors were significantly and independently associated with the presence of concurrent DVT/PE. Log BMI was significantly higher in the patients with isolated SVT. Factor V Leiden (FVL) was proved as an independent risk factor for concomitant DVT/PE with odds ratio 2,531 (95% CI 1,064-6,016). CONCLUSION: The prevalence of concurrent DVT/PE in patients with SVT, referred to hospital vascular clinic was 34.1%. Lower BMI (log BMI, respectively) and the presence of FVL were significantly and independently associated with concurrent DVT/PE. Our results should be further investigated in a larger prospective study.