- MeSH
- elektrokardiografie ambulantní metody využití MeSH
- ischemická choroba srdeční diagnóza MeSH
- klinická studie jako téma MeSH
- lidé středního věku MeSH
- lidé MeSH
- onemocnění periferních cév * krev patofyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srdeční arytmie diagnóza MeSH
- tlakový index kotník-paže metody využití MeSH
- vaskulární kalcifikace * komplikace MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
To provide an update of the literature describing the link between lipoprotein a and vascular disease. RECENT FINDINGS: There is evidence that elevated plasma lipoprotein a levels are associated with coronary heart disease, stroke and other manifestations of atherosclerosis. Several mechanisms may be implicated, including proinflammatory actions and impaired fibrinolysis. SUMMARY: Lipoprotein a potentially represents a useful tool for risk stratification in the primary and secondary prevention setting. However, there are still unresolved methodological issues regarding the measurement of lipoprotein a levels. Targeting lipoprotein a in order to reduce vascular risk is hampered by the lack of well tolerated and effective pharmacological interventions. Moreover, it has not yet been established whether such a reduction will result in fewer vascular events. The risk attributed to lipoprotein a may be reduced by aggressively tackling other vascular risk factors, such as low-density lipoprotein cholesterol.
- MeSH
- anticholesteremika terapeutické užití MeSH
- cévní mozková příhoda farmakoterapie krev MeSH
- fibrinolýza MeSH
- financování organizované MeSH
- hodnocení rizik MeSH
- lidé MeSH
- lipoprotein (a) krev MeSH
- nemoci koronárních tepen farmakoterapie krev MeSH
- onemocnění periferních cév farmakoterapie krev MeSH
- progrese nemoci MeSH
- rizikové faktory MeSH
- statiny terapeutické užití MeSH
- zánět MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Rheological conditions basically influence tissue perfusion, oxygen and nutrient supply, tissue regeneration and in its consequence the course of pathological processes, especially in microcirculation and partially even in macrocirculation. Haemorheotherapy has shown to be successful in several indications (critical disorders in microcirculation) when other methods of therapy have failed. In this study we describe the changes of effectivity indicators in haemorheopheresis treatment and their clinical importance in cases of eye microcirculation, statoacoustic apparatus and disorders of the lower extremities. We treated with haemorheopheresis (separator Cobe.Spetra + Evaflux filter) 24 patients (16 patients with age related macular degeneration, 5 with critical peripheral arterial foot disease, and 3 with acute hearing loss). After the procedures alpha2-macroglobulin decreases by about 58%, fibrinogen by about 69%, IgM by about 61%, LDL-cholesterol by about 77%, apolipoprotein B by about 76% and lipoprotein(a) by about 63%. It corresponds with a decrease in blood and plasma viscosity and clinical improvement in the observed patients, i.e. visual improvement, acceleration of tissue defect healing and improvement in hearing. We noticed 7.1% clinically insignificant side-effects. The method of haemorheopheresis was safe. It led to improvement in patients' clinical condition in the above mentioned indications when other methods of treatment failed.
- MeSH
- hyperlipidemie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- makulární degenerace krev terapie MeSH
- mikrocirkulace fyziologie MeSH
- náhlá nedoslýchavost krev terapie MeSH
- noha (od hlezna dolů) krevní zásobení patofyziologie MeSH
- obnova funkce MeSH
- onemocnění periferních cév krev terapie MeSH
- plazmaferéza MeSH
- senioři MeSH
- vředy na noze (od hlezna dolů) terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
The aim of our study was to evaluate the relationship of adiponectin to soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular cell adhesion molecule-1 (sICAM-1) in patients with cardiovascular disease or dyslipidemia. Two hundred and sixty-four patients (134 men/130 women, mean age 43.8+/-14.8/46.0+/-14.9 years) of Lipid Center, University Hospital Olomouc, off hypolipidemic therapy for at least 6 weeks, participated in the study. In multiple regression analysis, adiponectin was independently positively associated with serum HDL-cholesterol (p<0.0001) and sVCAM-1 (p<0.0001), female gender (p<0.0001) and negatively with hs-CRP (p=0.014). Serum concentration of adiponectin and sICAM-1 did not correlate but sICAM-1 was independently, positively associated with sVCAM-1 (p<0.0001) and negatively with markers of insulin resistance and inflammation, namely atherogenic index log[triglycerides/HDL-cholesterol] (p<0.0001), hs-CRP (p<0.001) and HOMA (p<0.05). Positive association of adiponectin with HDL-C and negative association with hs-CRP indicate anti-atherogenic properties of adiponectin. The finding of the positive association of adiponectin with sVCAM-1 in patients at risk is unexpected. We hypothesize that adiponectin may be involved (directly or indirectly) in shedding of ectodomains of VCAM-1 from endothelial surface and in this way down-regulates their effects. This process may be protective in the initial stages of atherosclerosis.
- MeSH
- adiponektin krev MeSH
- C-reaktivní protein MeSH
- cévní buněčněadhezivní molekula-1 krev MeSH
- cévní mozková příhoda krev MeSH
- dospělí MeSH
- epoxidové sloučeniny MeSH
- financování organizované MeSH
- HDL-cholesterol krev MeSH
- hypercholesterolemie krev MeSH
- hypertriglyceridemie krev MeSH
- inzulinová rezistence fyziologie MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mezibuněčná adhezivní molekula-1 krev MeSH
- nemoci koronárních tepen krev MeSH
- onemocnění periferních cév krev MeSH
- senioři MeSH
- zánět krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- cholesterol krev MeSH
- diabetes mellitus 2. typu diagnóza komplikace patologie MeSH
- dospělí MeSH
- hyperhomocysteinemie diagnóza krev patologie MeSH
- kardiovaskulární nemoci patologie MeSH
- lidé MeSH
- onemocnění periferních cév diagnóza krev patologie MeSH
- rizikové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- hodnotící studie MeSH
- MeSH
- cévní endotel patologie MeSH
- dospělí MeSH
- kardiovaskulární nemoci etiologie krev patologie MeSH
- lidé MeSH
- onemocnění periferních cév etiologie krev patologie MeSH
- sfingomyeliny MeSH
- vrozené poruchy metabolismu tuků komplikace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
