- Klíčová slova
- studie MAINTAIN, protein CD163,
- MeSH
- antigeny diferenciační myelomonocytární moč MeSH
- azathioprin terapeutické užití MeSH
- biologické markery moč MeSH
- CD antigeny moč MeSH
- imunosupresiva terapeutické užití MeSH
- indukční chemoterapie MeSH
- kombinovaná farmakoterapie MeSH
- kyselina mykofenolová * terapeutické užití MeSH
- lidé MeSH
- nefritida při lupus erythematodes * diagnóza farmakoterapie moč MeSH
- proteinurie MeSH
- randomizované kontrolované studie jako téma MeSH
- receptory buněčného povrchu analýza MeSH
- takrolimus terapeutické užití MeSH
- udržovací chemoterapie MeSH
- Check Tag
- lidé MeSH
BACKGROUND: Malignant pleural effusions accumulate in the space between the visceral (inner) layer covering the lungs and the parietal (outer) layer covering the chest wall. Larger effusions compress the pulmonary parenchyma resulting in increasing dyspnoea. Treatment is always local and palliative. Among others, chemical pleurodesis using talc can be performed in selected patients. Talc is hydrated magnesium silicate (chemically H₂Mg₃(SiO₃)₄) and has been used for pleurodesis since 1935. Videothoracoscopic talc powder insufflation (talc poudrage) is the most effective.However, markers of inflammatory reactions to extraneous substances like talc are not fully understood. The aim of this study was to assess the course of local inflammatory changes in the pleural cavity after talc insufflation. METHODS: The Department of Cardiac Surgery of the Faculty of Medicine and University Hospital in Hradec Kralove, treated 47 patients aged 65 on average; 29 males and 18 females with proven recurrent malignant pleural effusion of various aetiologies from January 2009 to December 2010. They were retrospectively divided into group A (40 patients) without recurring effusion, and group B (7 patients) with recurring effusion and the need for thoracentesis or chest drainage during the 9-month monitoring. RESULTS: Major findings were made in soluble forms of cell receptors. Group B showed statistically higher levels of the anti-inflammatory form of sCD-163 receptor in pleural fluid before the talc poudrage. This showed limited ability to create an adequate inflammatory response to external stimuli. This group also showed lower levels of the inflammatory form of sTLR-2 receptor immediately after the talc insufflation. This revealed low local reactivity to external stimuli. The effect of the treatment was not influenced by morphologic tumour type. No statistically significant differences in postoperative complications were found. This confirmed the safety of both videothoracoscopy and treatment. CONCLUSIONS: There was no correlation between the type of malignant affection and the outcome of the chemical pleurodesis. Patients with relapsing effusion have higher values of concentration of anti-inflammatory sCD-163 in pleural fluid even before the application of talc, and lower levels of concentration of inflammatory sTLR-2 immediately after application of talc.
- MeSH
- antigeny diferenciační myelomonocytární analýza MeSH
- biologické markery analýza MeSH
- CD antigeny analýza MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- maligní pleurální výpotek imunologie terapie MeSH
- mastek imunologie terapeutické užití MeSH
- pleurodéza * MeSH
- receptory buněčného povrchu analýza MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- toll-like receptor 2 analýza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- adenohypofýza chemie růst a vývoj MeSH
- dospělí MeSH
- křečci praví MeSH
- křeček rodu Mesocricetus růst a vývoj MeSH
- melatonin fyziologie MeSH
- novorozenec MeSH
- receptory buněčného povrchu analýza MeSH
- vývojová biologie MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- křečci praví MeSH
- novorozenec MeSH
- zvířata MeSH
- MeSH
- buněčné dělení účinky léků MeSH
- cyklické peptidy farmakologie MeSH
- endoteliny antagonisté a inhibitory MeSH
- gliom chemie patologie MeSH
- krysa rodu rattus MeSH
- molekulární sekvence - údaje MeSH
- receptory buněčného povrchu analýza antagonisté a inhibitory MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
