Background: Carbonated beverages are very popular worldwide. Carbonated beverage consumption vast increase raises great health concerns regarding their effect on calcium homeostasis besides obesity and renal function. Carbonated beverages sugar content, caffeine, and acidulant all can affect in a way or another calcium absorption, metabolism and excretion. The latter has direct effect on teeth, bone and general wellbeing. This study aims to reveal the effect of sub-chronic intake of carbonated beverage on urinary pH, crystalluria, calcium excretion.Methods: 21 healthy volunteers have been recruited in this study (9 males and 12 females) abstain for any carbonated beverages for at least the previous 4 weeks before participating in this study. Urine has been collected over 24 hours, the next day each volunteer has to drink 250 ml of carbonated beverage (Pepsi®) daily for 3 weeks. On the last day, urine was collected again over 24hr. pH, crystalluria, and calcium in urine have been measured.Results: Urine pH and crystalluria after 3 weeks' intake of 250 ml of carbonated beverage did not statistically differ from urine pH before the intake. Although, there was a trend toward reduction in pH and an increase in crystalluria. Total calcium excretion in urine increase was statistically significant when compared with calcium excretion at the study beginning.Conclusion: The regular intake of carbonated beverage (Pepsi®) increase calcium excretion. Thus, it may be advisable to increase the intake of milk or other dairy product to overcome the adverse impact of carbonated beverages.

• Klíčová slova
• Pepsi,
• MeSH
• analýza moči metody   MeSH
• klinická studie jako téma MeSH
• lidé MeSH
• močové kameny etiologie   moč   MeSH
• sycené nápoje * škodlivé účinky   MeSH
• vápník analýza   moč   MeSH
• Check Tag
• lidé MeSH

BACKGROUND: Fruit juice and soft drink consumption have been shown to be related to obesity. However, this relationship has not been explored in Eastern Europe. The present study aimed to assess the cross-sectional and longitudinal relationships between fruit juice, soft drink consumption and body mass index (BMI) in Eastern European cohorts. METHODS: Data from the Health, Alcohol and Psychosocial factors in Eastern Europe population-based prospective cohort study, based in Russia, Poland and the Czech Republic, were used. Intakes of sugar-sweetened beverage (SSB), artificially-sweetened beverage (ASB) and fruit juice were estimated from a food frequency questionnaire. Participant BMI values were assessed at baseline (n = 26 634) and after a 3-year follow-up (data available only for Russia, n = 5205). RESULTS: Soft drink consumption was generally low, particularly in Russia. Compared to never drinkers of SSB, participants who drank SSB every day had a significantly higher BMI in the Czech [β-coefficient = 0.28; 95% confidence interval (CI) = 0.02-0.54], Russian (β-coefficient = 1.38; 95% CI = 0.62-2.15) and Polish (β-coefficient = 0.83; 95% CI = 0.29-1.37) cohorts. Occasional or daily ASB consumption was also positively associated with BMI in all three cohorts. Results for daily fruit juice intake were inconsistent, with a positive association amongst Russians (β-coefficient = 0.75; 95% CI = 0.28-1.21) but a negative trend in the Czech Republic (β-coefficient = -0.42; 95% CI = -0.86 to 0.02). Russians participants who drank SSB or ASB had an increased BMI after follow-up. CONCLUSIONS: Our findings support previous studies suggesting that soft drink consumption (including SSBs and ASBs) is positively related to BMI, whereas our results for fruit juice were less consistent. Policies regarding these beverages should be considered in Eastern Europe to lower the risk of obesity.

• MeSH
• chování při pití MeSH
• dieta - přehledy MeSH
• index tělesné hmotnosti MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• následné studie MeSH
• obezita epidemiologie   etiologie   MeSH
• ovocné a zeleninové šťávy škodlivé účinky   statistika a číselné údaje   MeSH
• prospektivní studie MeSH
• průřezové studie MeSH
• senioři MeSH
• sycené nápoje škodlivé účinky   statistika a číselné údaje   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Geografické názvy
• Česká republika MeSH
• Polsko MeSH
• Rusko MeSH

OBJECTIVES: Oral health can affect quality of life in all course of life, which is a key factor of general health. Dental caries, periodontitis and oral cancer are of the highest burden of oral diseases. Rising prevalence of soft drinks and alcoholic beverages consumption due to easy access and socio-demographic altering has increased the concerns on oral health. In this review our purpose was to show effects of the most consumed beverages on oral health in people older than 15 years. METHODS: The review was based on papers published in last 10 years, searched with combined key words related to types of drinks and specific oral health problems. We included 4 older studies due to lack of newer studies on subjected topics. RESULTS: Sugar-free soft drinks are found less cariogenic and erosive than regular versions in limited number of studies. Alcohol consumption is shown as one of the risk factors of prevalence and severity of periodontitis and is proven to have synergistic effects along with tobacco on oral cancer risk. Consumption of soft drinks and alcoholic beverages was related with tooth loss whether dental caries or periodontal diseases. CONCLUSION: There is good evidence for association between soft drinks and oral health problems, but still no clear answer exists about strength of association between sugar-free soft drinks and dental caries. Also the knowledge about influence of alcohol is inadequate. Since consuming style affects erosive potential of drinks manufacturers should be required to add some recommendations on labels about drinking style.

• MeSH
• alkoholické nápoje škodlivé účinky   MeSH
• konzumní sacharóza škodlivé účinky   MeSH
• kvalita života MeSH
• lidé MeSH
• nápoje MeSH
• orální zdraví * MeSH
• sycené nápoje škodlivé účinky   MeSH
• zubní kaz etiologie   prevence a kontrola   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Potrava, některé její složky, nápoje a potravinové doplňky často ovlivňují metabolismus a transport léčiv v organismu nebo přímo farmakodynamické účinky léčiv. V důsledku těchto interakcí dochází ke změnám v biologické dostupnosti léčiv, ke snížení účinku nebo selhání terapie nebo ke zvýšení rizika výskytu nežádoucích účinků, výjimečně dokonce může dojít k projevům toxicity. Cílem přehledu je podat základní informaci o rozsahu aktuálních znalostí o interakcích potravy a nápojů s léčivy. Zejména pak ukázat na léčiva, která je z různých důvodů nezbytné užívat bud' nalačno, nebo po jídle a současně upozornit na skutečnost, že se léčiva mají zapíjet vodou.

Food, some of its ingredients, drinks and dietary supplements often affect the metabolism and transport of drugs in the body or directly the pharmacodynamic effects of drugs. As a result of these interactions, there is a change in the bioavailability of the drugs, in reducing the effect or failure of the therapy, or in increasing the risk of adverse reactions, and in exceptional cases there may be signs of toxicity. The aim of the review is to provide basic information about the extent of current knowledge about food and drink interactions with drugs. In particular, point to medicines that, for various reasons, need to be taken either on an empty stomach or after a meal, and at the same time to draw attention to the fact that medicines should be swallowed with water.

• MeSH
• ABC transportéry agonisté   antagonisté a inhibitory   fyziologie   MeSH
• abirateron terapeutické užití   MeSH
• absorpce v žaludku fyziologie   MeSH
• alkoholické nápoje škodlivé účinky   MeSH
• aplikace orální MeSH
• biologická dostupnost MeSH
• čaj enzymologie   fyziologie   MeSH
• enterocyty enzymologie   fyziologie   metabolismus   MeSH
• farmakoterapie metody   MeSH
• fyziologie výživy fyziologie   MeSH
• glukagonu podobný peptid 1 fyziologie   MeSH
• interakce bylin a léků fyziologie   MeSH
• interakce mezi potravou a léky * fyziologie   MeSH
• lidé MeSH
• mléko MeSH
• nežádoucí účinky léčiv MeSH
• ovocné a zeleninové šťávy škodlivé účinky   MeSH
• SLC transportéry agonisté   antagonisté a inhibitory   fyziologie   MeSH
• sycené nápoje škodlivé účinky   MeSH
• systém (enzymů) cytochromů P-450 fyziologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH
• přehledy MeSH

• MeSH
• artróza kyčelních kloubů farmakoterapie   MeSH
• dna (nemoc) epidemiologie   MeSH
• glukosamin aplikace a dávkování   MeSH
• hodnocení léčiv MeSH
• kašel farmakoterapie   MeSH
• lidé MeSH
• nachlazení farmakoterapie   MeSH
• naproxen aplikace a dávkování   farmakologie   MeSH
• prospektivní studie MeSH
• randomizované kontrolované studie jako téma MeSH
• sycené nápoje škodlivé účinky   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• klinické zkoušky MeSH