In the present study, inflation tests with free axial extension of 15 human vena saphena magna were conducted ex vivo to obtain data suitable for multi-axial constitutive modeling at overloading conditions (pressures up to approximately 15kPa). Subsequently the data were fitted with a hyperelastic, nonlinear and anisotropic constitutive model based on the theory of the closed thick-walled tube. It was observed that initial highly deformable behavior (up to approximately 2.5kPa) in the pressure-circumferential stretch response is followed by progressive large strain stiffening. Contrary to that, samples were much stiffer in longitudinal direction, where the observed stretches were in the range 0.98-1.03 during the entire pressurization in most cases. The effect of possible residual stress was evaluated in a simulation of the intramural stress distribution with the opening angle prescribed to 0°, 10°, 20°, 30°, 40°, and 50°. The result suggests that the optimal opening angle making the stress distribution through the wall thickness uniform is about 40°. The material parameters presented here are suitable for use in mechanobiological simulations describing the adaptation of the autologous vein wall after bypass surgery.
- MeSH
- biologické modely * MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mechanický stres MeSH
- senioři MeSH
- testování materiálů MeSH
- tlak * MeSH
- vena saphena anatomie a histologie fyziologie MeSH
- zatížení muskuloskeletálního systému MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: Damage to the saphenous nerve (SN) has been a known complication during varicose vein surgeries. We tested whether a better knowledge of the anatomy of the SN and the great saphenous vein (GSV) can prevent such damage. METHODS: We conducted a morphological and histological examination on 86 limbs from 43 cadavers in order to analyse the anatomical interrelation between the SN and the GSV in the lower leg and we also measured the distance between the nerve and the vein in a sample of 42 sections from three parts of the lower leg. RESULTS: The anatomical relationship between the SN and the GSV is varied and the two structures run close to each other so a better knowledge of their anatomy in itself proved insufficient in preventing damage to the SN. CONCLUSION: However, in the case of endovenous laser therapy and radiofrequency ablation tumescent anaesthesia decreases the risk of damage to the SN.
- MeSH
- bérec krevní zásobení inervace MeSH
- laserová terapie MeSH
- lidé MeSH
- mrtvola MeSH
- periferní nervový systém anatomie a histologie MeSH
- vena saphena anatomie a histologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- diagnostické techniky kardiovaskulární MeSH
- dolní končetina patologie ultrasonografie MeSH
- duplexní dopplerovská ultrasonografie metody přístrojové vybavení MeSH
- flebitida diagnóza ultrasonografie MeSH
- horní končetina patologie ultrasonografie MeSH
- lidé MeSH
- onemocnění periferních cév diagnóza ultrasonografie MeSH
- tromboembolie diagnóza ultrasonografie MeSH
- vena saphena anatomie a histologie ultrasonografie MeSH
- vény ultrasonografie MeSH
- žilní tromboembolie diagnóza ultrasonografie MeSH
- žilní trombóza diagnóza ultrasonografie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
OBJECTIVE: The detailed spatial arrangement of the vasa vasorum (VV) of the human great saphenous vein (HGSV) was demonstrated in qualitative and quantitative terms. MATERIALS AND METHODS: Segments of the HGSV taken from cadavers 12-24 h post mortem and from patients undergoing aortocoronary bypassing were studied by light microscopy of India-ink-injected specimens and by scanning electron microscopy of vascular corrosion casts. RESULTS: Arterial feeders were found to approach the HGSV from nearby arteries every 15 mm forming a rich capillary network within the adventitia and the outer two thirds of the media in normal HGSV, while in HGSV with intimal hyperplasia capillary meshes extended into the inner layers of the media. Within the media, capillary meshes ran circularly. Postcapillary venules drained centrifugally towards the adventitial venous vessels which finally formed venous drainers running adjacent to the arterial feeders. Three-dimensional morphometry of vascular corrosion casts of VV revealed that diameters of (i) arterial VV ranged from 11.6 to 36.6 microm, (ii) capillary VV from 4.7 to 11.6 microm and (iii) venous VV ranged from 11.6 to 200.3 microm. CONCLUSIONS: The 3D network of VV suggests these layers are metabolically highly active and therefore require a continuous blood supply. We conclude, therefore, that the VV network must be preserved during in situ bypassing. Copyright 2007 S. Karger AG, Basel.
- MeSH
- dospělí MeSH
- financování organizované MeSH
- kapiláry ultrastruktura MeSH
- korozní odlévání MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikroskopie elektronová rastrovací MeSH
- senioři MeSH
- uhlík MeSH
- vasa vasorum anatomie a histologie ultrastruktura MeSH
- vena saphena anatomie a histologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
