* Zobrazit nápovědu

21 záznamů v Medvik Filtry

Článek

Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices

Manoušek, Jan
Autor Manoušek, Jan Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic
Andršová, Irena
Autor Andršová, Irena Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic
Stejskal, Vera
Autor Stejskal, Vera Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic
Vlašínová, Jitka
Autor Vlašínová, Jitka Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic
Sepši, Milan
Autor Sepši, Milan Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic. Faculty of Medicine, Department of Internal Medicine and Cardiology, Masaryk University, Kamenice 753/5, Brno, Czech Republic
Kuta, Jan
Autor Autorita Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic
Klánová, Jana
Autor Klánová, Jana Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic
Mazík, Michal
Autor Mazík, Michal Methodical Centre for Conservation, Technical Museum in Brno, Purkynova 105, Brno, Czech Republic
Jarkovský, Jirí
Autor Jarkovský, Jirí Faculty of Medicine, Department of Internal Medicine and Cardiology, Masaryk University, Kamenice 753/5, Brno, Czech Republic. Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Kamenice 126/3, Brno, Czech Republic
Šnajdrová, Lenka
Autor Šnajdrová, Lenka Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Kamenice 126/3, Brno, Czech Republic

Europace. 2018 ; 20 (9) : e140-e147. [pub] 20180901

ISSN 1532-2092
Medvik
Zdroj

Aims: To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results: The cohort consisted of 20 men and 4 women (mean age: 62.3 ± 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 ± 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion: Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.

Článek

Trendem v celkové parenterální výživě je snížit její toxicitu

AM Review. 2016 ; 2016 (13) : 33-36. (Kongresová review)

ISSN 2336-7326
Medvik
Zdroj

MeSH
fyziologie výživy MeSH
kongresy jako téma MeSH
lidé MeSH
mangan * aplikace a dávkování škodlivé účinky toxicita MeSH
mikroživiny * MeSH
parenterální výživa škodlivé účinky MeSH
roztoky pro parenterální výživu * chemie normy škodlivé účinky toxicita MeSH
stopové prvky MeSH
vitaminy MeSH
Check Tag
lidé MeSH
Publikační typ
zprávy MeSH

Článek

Geographic accumulation of Creutzfeldt-Jakob Disease in Slovakia - environmental metal imnalance as a possible cofactor

Central European Journal of Public Health. 2011 ; 19 (3) : 158-164.

Medvik
Zdroj

Slovakia is characterised by an unusually high number of patients affected by genetic Creutzfeldt-Jakob disease (CJD) with E200K mutation at the PRNP gene. Penetrance of the mutation is incomplete (59%). Therefore, for the onset of the clinical manifestation, an influence of other endo- or exogenous factors could not be excluded. Experimental data suggest that copper and manganese levels may play an important role in the pathogenesis of prion diseases. The highest number of Slovak genetic CJD patients originates from Orava – the northern region of central Slovakia. Manganese is a dominant pollutant in Orava. The objective of this study was to clarify a possible exogenous influence of environmental Mn/Cu imbalance on the CJD clustering. Mn and Cu levels were analysed in the brain tissue of genetic CJD cases (from Orava and from control regions of Slovakia), as well as of sporadic CJD patients and controls. Analyses demonstrate i) significantly higher Mn level in focally accumulated, "clustering" genetic CJD cases in comparison to all other groups, ii) Cu status differences between compared groups were without statistical significance; decreased concentrations were found in genetic cases from extrafocal genetic CJD areas, iii) Mn/Cu ratios were increased in all CJD groups in comparison to controls. Metal ratios in clustering gCJD cases were significantly higher in comparison to sporadic cases and also to controls, but not to the extrafocal genetic CJD subgroup. These results indicate that more important than increasing Mn level in pathogenesis of CJD appears to be the role of the Mn/Cu imbalance in the CNS. The imbalance observed in the cluster of genetic CJD cases is probably a result of both: the excessive environmental Mn level and the disturbance of Mn/Cu ratios in the Orava region. Presented findings indicate an environmental Mn/Cu imbalance as a possible exogenous CJD risk co-factor which may, in coincidence with endogenous (genetic) CJD risk, contribute to the focal accumulation (cluster) of genetic CJD in Slovakia.