• MeSH
• Adrenal Cortex Neoplasms complications   MeSH
• Pain radiotherapy   MeSH
• Radiotherapy Dosage MeSH
• Humans MeSH
• Neoplasm Metastasis MeSH
• Palliative Care MeSH
• Check Tag
• Humans MeSH

• MeSH
• Estriol analysis   blood   MeSH
• Ichthyosis, X-Linked diagnosis   MeSH
• Prenatal Diagnosis MeSH

• Publication type
• Meeting Abstract MeSH

Purpose: People chronically infected with hepatitis C virus (HCV) have diminished patient-reported outcomes (PROs). This study aimed to compare the impact of elbasvir/grazoprevir (EBR/GZR) treatment versus sofosbuvir with pegylated interferon and ribavirin (SOF/PR) on changes in PROs: 1) during the treatment period and 2) at posttreatment follow-up. Patients and methods: PRO data collected during the Phase III C-EDGE Head-2-Head (H2H) open-label study was analyzed. In this trial, patients infected with HCV were randomized 1:1 to receive either EBR/GZR or SOF/PR for 12 weeks. Patients self-administered the Short Form-36 version 2 (SF-36v2®) Health Survey Acute (1-week recall) Form and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scale at baseline, during treatment, and posttreatment. Between-group differences in mean change of PRO scores from baseline were estimated during the treatment period and also at the posttreatment follow-up. Effect sizes were calculated to evaluate if the detected change in mean PRO scores is clinically meaningful between groups. Results: There were 255 patients (99.2% White, 54.1% female, 74.9% treatment naïve) included in the analysis. During the treatment period, significant declines in SF-36v2 scores were observed across all domains for the SOF/PR group. Compared to the SOF/PR group, the EBR/GZR group reported more improvement in scores across all SF-36v2 domain scores at the end of the treatment period. At treatment week 12, the between-group differences for 6 out of the 8 domain scores for these patients reflected at least moderate effects (effect sizes >0.5). No significant between-group differences in change in SF-36v2 scores from baseline were detected posttreatment. The decline in SF-36v2 scores observed during the treatment period for the SOF/PR group returned to near baseline scores or above posttreatment. Treatment with EBR/GZR did not impact fatigue scores, but treatment with SOF/PR led to increased fatigue scores during treatment which resolved by posttreatment follow-up week 12. Conclusion: This study demonstrated that HCV treatment with EBR/GZR resulted in a significantly better PRO profile as compared to SOF/PR. PROs are an important consideration as worsening PROs experienced during treatment may negatively influence adherence and ultimately contribute to an unfavorable clinical outcome. Clinicaltrialsgov Identifier: NCT02358044.

• Publication type
• Journal Article MeSH

• Keywords
• standardy, kardiovaskulární riziko, hypertenze bílého pláště,
• MeSH
• Monitoring, Ambulatory economics   methods   utilization   MeSH
• Antihypertensive Agents adverse effects   therapeutic use   MeSH
• Hypertension diagnosis   prevention & control   MeSH
• Cardiovascular Diseases MeSH
• Humans MeSH
• Masked Hypertension diagnosis   MeSH
• Evidence-Based Medicine trends   MeSH
• Blood Pressure Determination methods   utilization   MeSH
• Meta-Analysis as Topic MeSH
• Risk Factors MeSH
• Practice Guidelines as Topic standards   MeSH
• Societies, Medical MeSH
• White Coat Hypertension diagnosis   MeSH
• Check Tag
• Humans MeSH

Publikace hradla, volty, jednočipy je určena pro zájemce o elektroniku, číslicovou techniku a vlastní stavbu zařízení pro Internet věcí. U čtenáře předpokládá běžné zkušenosti s počítačovou technikou. Znalost programování není nutná, i když ji v některých příkladech čtenář využije. Výklad pokrývá oblast od naprostých základů (napětí, proud, odpor, Ohmův zákon) přes základní elektronické součástky a řadu číslicových obvodů TTL (74xx) až po specializované součástky, jako jsou čidla, polovodičové paměti a jednočipové počítače.

Photosynthesis research employs several biophysical methods, including the detection of fluorescence. Even though fluorescence is a key method to detect photosynthetic efficiency, it has not been applied/adapted to single-cell confocal microscopy measurements to examine photosynthetic microorganisms. Experiments with photosynthetic cells may require automation to perform a large number of measurements with different parameters, especially concerning light conditions. However, commercial microscopes support custom protocols (through Time Controller offered by Olympus or Experiment Designer offered by Zeiss) that are often unable to provide special set-ups and connection to external devices (e.g., for irradiation). Our new system combining an Arduino microcontroller with the Cell⊕Finder software was developed for controlling Olympus FV1000 and FV1200 confocal microscopes and the attached hardware modules. Our software/hardware solution offers (1) a text file-based macro language to control the imaging functions of the microscope; (2) programmable control of several external hardware devices (light sources, thermal controllers, actuators) during imaging via the Arduino microcontroller; (3) the Cell⊕Finder software with ergonomic user environment, a fast selection method for the biologically important cells and precise positioning feature that reduces unwanted bleaching of the cells by the scanning laser. Cell⊕Finder can be downloaded from http://www.alga.cz/cellfinder. The system was applied to study changes in fluorescence intensity in Synechocystis sp. PCC6803 cells under long-term illumination. Thus, we were able to describe the kinetics of phycobilisome decoupling. Microscopy data showed that phycobilisome decoupling appears slowly after long-term (>1 h) exposure to high light.

• MeSH
• Microscopy, Confocal instrumentation   methods   MeSH
• Automation, Laboratory instrumentation   methods   MeSH
• Lighting MeSH
• Software MeSH
• Synechocystis chemistry   ultrastructure   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].

• MeSH
• Chemistry, Pharmaceutical trends   MeSH
• Humans MeSH
• Drug Discovery trends   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Editorial MeSH

This study focuses on the sensory systems application in dog´s movements with visual impairment. The aim of this work was realization and design the production of orthotic instrument for the blind dog because of there has been nothing similar at the market available yet. The work has used non-invasive detection of the animal´s body measure. An instrument has been generated by using CAD software. By help of 3D printer, the virtual model has become real. The product has been cleansed and a system for gripping and for eye protectors has been applied. By studying different types of sensor for application we have decided to choose an ultrasonic position sensor which is harmless for dog´s hearing. A sensor has detected an approaching obstacle by using the Arduino platform. The obtained results and production of this device can be helpful in innovative development of finding new ways in animal´s rehabilitation as well as in rehabilitation of people.

Po knize Hradla, volty, jednočipy přichází autor s volným pokračováním, v němž se od základů číslicové techniky přesuneme ke konstrukci složitějších obvodů - totiž vlastních počítačů. Na příkladu tří podrobně popsaných konstrukcí se čtenář naučí základní principy fungování osmibitových počítačů a vyzkouší si i jejich praktický návrh a zapojování. Konstrukce používají legendární osmibitové procesory Intel 8085, MOS 65C02 a Motorola 6809. Kniha popisuje nejen jejich zapojení, ale věnuje se i jejich programování ve strojovém kódu (assembleru). Autor se nevyhnul ani pokročilejším tématům, jako je generování zvuku, zapojování periferií nebo různým způsobům rozšiřování paměti. Všechny konstrukce jsou prakticky ověřené, a ačkoli vycházejí z "ducha osmdesátých let", tak používají součástky, které lze i dnes poměrně dobře sehnat. Kniha je doplněna online dokumentací jednotlivých konstrukcí, ukázkami programového vybavení a dodatkovým materiálem.; Na příkladu tří podrobně popsaných konstrukcí se čtenář naučí základní principy fungování osmibitových počítačů a vyzkouší si i jejich praktický návrh a zapojování.Kniha popisuje nejen jejich zapojení, ale věnuje se i jejich programování ve strojovém kódu (assembleru). Autor se nevyhnul ani pokročilejším tématům, jako je generování zvuku, zapojování periferií nebo různým způsobům rozšiřování paměti. Kniha je doplněna online dokumentací jednotlivých konstrukcí, ukázkami programového vybavení a dodatkovým materiálem.