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In this work, we have designed, constructed, and evaluated simple, inexpensive open-source data acquisition systems based on various analog-to-digital converter modules (ADS 1115, MCP 3424, LTC 2400, with resolution from 16 to 24-bit) and a miniature Arduino Nano TM microcontroller. The constructed data acquisition systems provide excellent performance and are comparable to a commercial, 24-bit device. We provide full schematics and corresponding source codes so that analytical chemists can easily construct any of the developed systems without extensive electronic or programming knowledge. The 24-bit LTC 2400 based device provided the best and comparable performance to a commercial, high-end 24-bit sigma to delta converter (ORCA 2800) at a fraction of cost (less than 50 USD compared to 870 USD for the commercial counterpart). The excellent performance was verified using a capillary electrophoresis system with contactless conductivity detection and separation of inorganic ions in clinical skin wipe and tap water samples.
- MeSH
- elektrická vodivost MeSH
- elektroforéza kapilární * MeSH
- ionty MeSH
- software * MeSH
- voda MeSH
- Publikační typ
- časopisecké články MeSH
Purpose: People chronically infected with hepatitis C virus (HCV) have diminished patient-reported outcomes (PROs). This study aimed to compare the impact of elbasvir/grazoprevir (EBR/GZR) treatment versus sofosbuvir with pegylated interferon and ribavirin (SOF/PR) on changes in PROs: 1) during the treatment period and 2) at posttreatment follow-up. Patients and methods: PRO data collected during the Phase III C-EDGE Head-2-Head (H2H) open-label study was analyzed. In this trial, patients infected with HCV were randomized 1:1 to receive either EBR/GZR or SOF/PR for 12 weeks. Patients self-administered the Short Form-36 version 2 (SF-36v2®) Health Survey Acute (1-week recall) Form and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) Scale at baseline, during treatment, and posttreatment. Between-group differences in mean change of PRO scores from baseline were estimated during the treatment period and also at the posttreatment follow-up. Effect sizes were calculated to evaluate if the detected change in mean PRO scores is clinically meaningful between groups. Results: There were 255 patients (99.2% White, 54.1% female, 74.9% treatment naïve) included in the analysis. During the treatment period, significant declines in SF-36v2 scores were observed across all domains for the SOF/PR group. Compared to the SOF/PR group, the EBR/GZR group reported more improvement in scores across all SF-36v2 domain scores at the end of the treatment period. At treatment week 12, the between-group differences for 6 out of the 8 domain scores for these patients reflected at least moderate effects (effect sizes >0.5). No significant between-group differences in change in SF-36v2 scores from baseline were detected posttreatment. The decline in SF-36v2 scores observed during the treatment period for the SOF/PR group returned to near baseline scores or above posttreatment. Treatment with EBR/GZR did not impact fatigue scores, but treatment with SOF/PR led to increased fatigue scores during treatment which resolved by posttreatment follow-up week 12. Conclusion: This study demonstrated that HCV treatment with EBR/GZR resulted in a significantly better PRO profile as compared to SOF/PR. PROs are an important consideration as worsening PROs experienced during treatment may negatively influence adherence and ultimately contribute to an unfavorable clinical outcome. Clinicaltrialsgov Identifier: NCT02358044.
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- standardy, kardiovaskulární riziko, hypertenze bílého pláště,
- MeSH
- ambulantní monitorování ekonomika metody využití MeSH
- antihypertenziva škodlivé účinky terapeutické užití MeSH
- hypertenze diagnóza prevence a kontrola MeSH
- kardiovaskulární nemoci MeSH
- lidé MeSH
- maskovaná hypertenze diagnóza MeSH
- medicína založená na důkazech trendy MeSH
- měření krevního tlaku metody využití MeSH
- metaanalýza jako téma MeSH
- rizikové faktory MeSH
- směrnice pro lékařskou praxi jako téma normy MeSH
- společnosti lékařské MeSH
- syndrom bílého pláště diagnóza MeSH
- Check Tag
- lidé MeSH
... Arduina 144 -- 9.3 Blikání Arduinem 145 -- 9.4 Krok zpět ? ... ... drátům 146 -- 9.5 Arduino a EduShield 149 -- 10 Fotorezistor 153 -- 10.1 Obrácená logika 154 -- 10.2 ... ... Trimry 155 -- 10.3 Lepší řešení detektoru tmy 156 -- 10.4 Fotorezistor a Arduino 157 -- 11 Termistor ... ... - 13.10 Pomalé tlačítko -- 13.11 Schmittův obvod -- 13.12 Blokovací kondenzátor -- 13.13 Buzení z Arduina ... ... Dl Mini, NodeMCU 466 -- 37.4 Bezdrátový teploměr s WiFi 467 -- 37.5 Instalace podpory ESP8266 do Arduino ...
1. elektronické vydání 1 online zdroj (514 stran)
Publikace hradla, volty, jednočipy je určena pro zájemce o elektroniku, číslicovou techniku a vlastní stavbu zařízení pro Internet věcí. U čtenáře předpokládá běžné zkušenosti s počítačovou technikou. Znalost programování není nutná, i když ji v některých příkladech čtenář využije. Výklad pokrývá oblast od naprostých základů (napětí, proud, odpor, Ohmův zákon) přes základní elektronické součástky a řadu číslicových obvodů TTL (74xx) až po specializované součástky, jako jsou čidla, polovodičové paměti a jednočipové počítače.
Photosynthesis research employs several biophysical methods, including the detection of fluorescence. Even though fluorescence is a key method to detect photosynthetic efficiency, it has not been applied/adapted to single-cell confocal microscopy measurements to examine photosynthetic microorganisms. Experiments with photosynthetic cells may require automation to perform a large number of measurements with different parameters, especially concerning light conditions. However, commercial microscopes support custom protocols (through Time Controller offered by Olympus or Experiment Designer offered by Zeiss) that are often unable to provide special set-ups and connection to external devices (e.g., for irradiation). Our new system combining an Arduino microcontroller with the Cell⊕Finder software was developed for controlling Olympus FV1000 and FV1200 confocal microscopes and the attached hardware modules. Our software/hardware solution offers (1) a text file-based macro language to control the imaging functions of the microscope; (2) programmable control of several external hardware devices (light sources, thermal controllers, actuators) during imaging via the Arduino microcontroller; (3) the Cell⊕Finder software with ergonomic user environment, a fast selection method for the biologically important cells and precise positioning feature that reduces unwanted bleaching of the cells by the scanning laser. Cell⊕Finder can be downloaded from http://www.alga.cz/cellfinder. The system was applied to study changes in fluorescence intensity in Synechocystis sp. PCC6803 cells under long-term illumination. Thus, we were able to describe the kinetics of phycobilisome decoupling. Microscopy data showed that phycobilisome decoupling appears slowly after long-term (>1 h) exposure to high light.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].
