Classifying a measurable clinical outcome as a dichotomous variable often involves difficulty with borderline cases that could fairly be assigned either of the two binary class memberships. In such situations the indicated class membership is often highly subjective and subject to, for instance, a measurement error. In other situations the intermediate level of a three-level ordinal factor may sometimes be explicitly reserved for cases which could likely belong to either of the two binary classes. Such indefinite readings are often eliminated from the statistical analysis. In this article we review conceptual and methodological aspects of employing proportional odds logistic regression for a three level ordinal factor as a suitable alternative to ordinary logistic regression when dealing with limited uncertainty in classifying clinical outcome as a binary variable. Copyright 2006 John Wiley & Sons, Ltd.

• MeSH
• Atherosclerosis ultrasonography   MeSH
• Cholesterol blood   MeSH
• Data Interpretation, Statistical * MeSH
• Smoking MeSH
• Blood Glucose metabolism   MeSH
• Humans MeSH
• Logistic Models * MeSH
• Predictive Value of Tests MeSH
• Models, Statistical * MeSH
• Calcium blood   MeSH
• Check Tag
• Humans MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH

The preorbital gland plays not only an olfactory role in cervids but also a visual one. Opening this gland is an easy way for the calf to communicate with the mother, indicating hunger/satiety, stress, pain, fear, or excitement. This information can be also useful for farm operators to assess how fast the calves habituate to handling routines and to detect those calves that do not habituate and may suffer chronic stress in the future. Thirty-one calves were subjected to 2 consecutive experiments to clarify if observing preorbital gland opening is related to habituation to handling in red deer calves (Cervus elaphus). Calves were born in 3 different paddocks, handled as newborns (Exp. 1), and then subjected to the same routine handling but with different periodicity: every 1, 2, or 3 wk (Exp. 2). In Exp. 1, preorbital gland opening was recorded in newborns during an initial handling (including weighing, ear tagging, and sex determination). Preorbital gland opening occurred in 93% of calves during this procedure and was not affected by sex, time since birth, or birth weight. Experiment 2 consisted of measuring preorbital opening during the same routine handling (weighing, blood sampling, and rump touching to assess body condition) when calves were 1, 3, and 5 mo old. Binary logistic regression showed that gland opening was associated with habituation to handling, since at 1 and 3 mo the probability of opening the gland decreased with the number of handlings that a calf experienced before (P = 0.008 and P = 0.028, respectively). However, there were no further changes in preorbital gland opening rate in the 5-mo-old calves (P = 0.182). The significant influence of the number of previous handlings on the probability of opening the preorbital gland was confirmed through generalized linear model with repeated measures (P = 0.007). Preorbital gland opening decreased along the phases of the study. Nevertheless, we found a significant trend in individuals to keep similar opening patterns (intraclass correlation coefficient = 0.807, P < 0.001), which suggests that the more stressed individuals can be detected with this method. Therefore, we conclude that preorbital gland opening during routine handlings is related to the number of previous handlings, and thus it can be used as an indicator of lack of habituation to handling in farmed cervids.

• MeSH
• Habituation, Psychophysiologic physiology   MeSH
• Handling, Psychological * MeSH
• Animal Communication * MeSH
• Linear Models MeSH
• Logistic Models MeSH
• Lacrimal Apparatus physiology   MeSH
• Age Factors MeSH
• Deer physiology   MeSH
• Animals MeSH
• Check Tag
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Clinical Trial MeSH
• Research Support, Non-U.S. Gov't MeSH

OBJECTIVE: The aim of this study was to assess CD45-positive platelets (CD45+ platelets) involvement in restenosis development after drug-eluting stent (DES) implantation in patients with stable coronary artery disease (CAD). METHODS: The study comprised 126 male and female patients with stable angina pectoris, who underwent elective coronary stenting with DES and follow-up angiography within 6-12 months. The patients were assigned to the group with restenosis (n = 53) or group without restenosis (n = 73) according to the follow-up angiograms. In both groups we compared the level in blood of CD45+ platelets, the clinical, laboratory and angiographic variables, which may affect the development of restenosis. We have also constructed a logit regression model for prognosis of restenosis occurrence after DES implantation. RESULTS: The blood count of CD45+ platelets was higher in patients with restenosis than in patients without: 0.82 % (0.58; 1.12) vs. 0.34 % (0.20; 0.68), p < 0.001, data are expressed as median (lower quartile; upper quartile). By binary comparisons of more than 35 different clinical, laboratory and angiographic variables we identified 8 significant risk factors for the development of stent restenosis after DES. In order to define the risk of the development of restenosis, we have built a logit regression model. The resulting logit regression equation included the level of CD45+ platelets, the neutrophil to lymphocyte ratio (NLR), small diameter arteries stenting and the number of simultaneously implanted stents in one patient. Receiver operating characteristic (ROC) curve analysis has demonstrated the high prognostic value of the resulting logit regression equation with an area under the curve (AUC) of 0.91 % (p < 0.001). CONCLUSIONS: The acquired data indicate the presence of a close relationship between circulating CD45+ platelets and restenosis development after DES implantation in patients with stable CAD.

• MeSH
• Leukocyte Common Antigens blood   MeSH
• Biomarkers blood   MeSH
• Adult MeSH
• Risk Assessment methods   MeSH
• Causality MeSH
• Comorbidity MeSH
• Coronary Restenosis blood   epidemiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Coronary Artery Disease blood   epidemiology   therapy   MeSH
• Graft Occlusion, Vascular blood   epidemiology   MeSH
• Platelet Count statistics & numerical data   MeSH
• Prevalence MeSH
• Proportional Hazards Models MeSH
• Retrospective Studies MeSH
• Risk Factors MeSH
• Aged MeSH
• Drug-Eluting Stents statistics & numerical data   MeSH
• Blood Platelets pathology   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Russia epidemiology   MeSH

Although obesity is a multifactorial disorder caused by various behavioural, genetic and environmental influences, early life factors affecting certain critical periods during childhood (prenatal period, adiposity rebound period at 3-5 years and around 5-7 years, as well as puberty) are important in promoting obesity in adulthood. The objective was to determine the association between the birth weight, birth length, breastfeeding and time of introduction of complementary food with obesity among 302 healthy Caucasian children 6-7 years old. Binary logistic regression analysis was used to assess the impact of a number of perinatal and socioeconomic confounding factors on the likelihood for overweight and obesity among children. The level of significance was set at p <0.05. Our findings indicate that duration of breastfeeding for at least 3 months, with introduction of complementary food after the age of 6 months have an important role in preventing obesity. This findings are crucial for planning preventive strategies to prevent further increases in the prevalence of overweight and obesity.

• MeSH
• White People MeSH
• Child MeSH
• Body Mass Index MeSH
• Breast Feeding * MeSH
• Humans MeSH
• Logistic Models MeSH
• Pediatric Obesity etiology   prevention & control   MeSH
• Child, Preschool MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Male MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Aim: Research on the health consequences of violent victimization of people with disabilities is lacking. This study aims to identify the factors that are associated with physical and mental health impacts of anti-disability bias victimization. Methods: The study drew on a unique sample of 331 self-identified people with disabilities, all over the age of 15, residing in Czechia. From this sample, 47 questionnaires were excluded. The respondents were asked about the most serious incident of anti-disability bias victimization in the last five years. A series of bivariate binary logistic regressions were performed - with the consequences of this incident as outcomes (mental health and physical health). Results: 90 respondents (32%) reported experiencing the most serious incident of bias victimization in the last five years. 60% of victims reported anxiety and sadness, and 28% deterioration in physical health. The results suggest that victims experience physical and mental health consequences unequally. Age, perceived disability in specific areas, visibility of disability, presence of multiple disabilities, and number of offenders are associated with the experience of physical health deterioration. Education, perceived disability in specific areas, and visibility of disability are associated with the experience of mental health impacts. Conclusion: Certain groups of people with disabilities who experience victimization report poorer physical and mental health outcomes. This differential experience should be considered in immediate responses and prevention programs.

• MeSH
• Mental Health statistics & numerical data   MeSH
• Emotions MeSH
• Humans MeSH
• Logistic Models MeSH
• Violence psychology   statistics & numerical data   MeSH
• Persons with Disabilities * psychology   statistics & numerical data   MeSH
• Prejudice * psychology   statistics & numerical data   MeSH
• Social Problems psychology   statistics & numerical data   MeSH
• Health statistics & numerical data   MeSH
• Self Report MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

AIM: The purpose of this study was to asses the impact of haemostatic and platelet receptor gene polymorphisms as an inherited risk factor for premature onset of myocardial infarction (MI). METHODS: Polymorphisms of platelet receptors - GP Ia (807C>T, rs1126643), GP VI (13254T>C, rs1613662), GP IIIa (HPA-1, rs5918), PAR -1 (IVS -14A>T; rs168753), P2Y(12) (34C>T, rs6785930 and H1/H2 haplotype, rs2046934), and genetic variations of the gene coding for cyclooxygenase-1 (COX-1) ( -842A>G, rs10306114 and 50C>T, rs3842787) were investigated. Mutations in the genes coding for coagulation factor V (Q506R (Leiden) mutation, rs6025) and factor II (prothrombin G20210A, rs1799963) were also determined. The prevalence of gene polymorphisms was investigated in 105 consecutive patients with premature MI. This was compared with the same gene polymorphism prevalence in a group of 132 patients in which coronary artery disease had been excluded. Genotyping was done using PCR, followed by melting curve analysis with specific fluorescent hybridization probes. RESULTS: A significant association between GP VI 13254C allele carriers and premature MI was found (p=0.025). No other differences in prevalence of the investigated polymorphisms between the compared patient populations reached statistical significance. In a logistic regression, which took other cardiovascular risk factors into account, the significance of the GP VI 13254C allele and vascular risk was suggested (OR 1.888, 95% C.I. 1.029 to 3.464, p=0.040). In a binary logistic regression the positive relationship between the GP VI genotype and female gender was observed (0R 3.676; 95% C.I. 1.159 to 11.628; p=0.027). The frequencies of GP VI and GP Ia gene polymorphisms were independent of one another (p=0.836). CONCLUSION: The presence of the GP VI 13254C allele is an independent predictor of premature MI.

• MeSH
• Alleles MeSH
• Adult MeSH
• Gene Frequency MeSH
• Genotype MeSH
• Platelet Membrane Glycoproteins analysis   genetics   MeSH
• Myocardial Infarction genetics   MeSH
• Middle Aged MeSH
• Humans MeSH
• Logistic Models MeSH
• Polymorphism, Genetic MeSH
• Randomized Controlled Trials as Topic MeSH
• Risk Factors MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

OBJECTIVES: The US shows a distinct health disadvantage when compared to other high-income nations. A potential lever to reduce this disadvantage is to improve the health situation of lower socioeconomic groups. Our objective is to explore how the considerable within-US variation in health inequalities compares to the health inequalities across other Western countries. METHODS: Representative survey data from 44 European countries and the US federal states were obtained from the fourth wave of the European Values Study (EVS) and the 2008 wave of the Behavioral Risk Factor Surveillance System. Using binary logistic regression, we analyze different forms of educational inequalities in self-rated health (SRH), adjusted for age and sex. RESULTS: The extent of educational inequalities in SRH varies considerably over European countries and US states; with US states in general showing greater inequality, however, differences between US states and European countries are less clear than commonly assumed. CONCLUSIONS: The US has considerable differences in educational inequalities in SRH across geographic locations. To understand the reasons for the US health disadvantage, comparative research has to take into account the vast variation in health inequalities within the US.

• MeSH
• Behavioral Risk Factor Surveillance System MeSH
• Health Status Disparities * MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Logistic Models MeSH
• Surveys and Questionnaires MeSH
• Aged MeSH
• Educational Status * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Geographicals
• Europe epidemiology   MeSH
• United States epidemiology   MeSH

BACKGROUND: Oral health strongly affects overall health and is related to many factors. The aim of our study was to analyse oral health related behaviours (OHRBs) and gum bleeding among Slovak adolescents and assess the effect of socioeconomic factors on the outcomes. METHODS: Data from the Health Behaviour in School-aged Children study (HBSC) were used (N = 8896, age range = 10-16 years, M = 13.4; SD = 1.4; 50.9% boys). Sociodemographic and socioeconomic indicators and frequency of OHRBs (dental hygiene, toothbrush changing, preventive check-up) and gum bleeding were collected. Effects of sociodemographic and socioeconomic variables on outcome variables were analysed by binary logistic regression. RESULTS: We found that prevalence of OHRBs slightly decreases with age, and worse outcomes were reported by boys compared to girls (OHRB odds ratio range 0.45-0.75, (95% C.I. range 0.40-0.91), gum bleeding 1.38 (95% C.I. 1.19-1.61), p < 0.05). OHRBs were in most cases significantly associated with socioeconomic variables, lower affluence predicts worse outcomes (odds ratio range 0.76-0.88 (95% C.I. range 0.68-0.96), p < 0.05). CONCLUSION: Our study provides representative findings on ORHBs in Slovakia and shows important associations of socioeconomic factors related to adolescents' oral health issues.

• MeSH
• Adolescent Behavior MeSH
• Toothbrushing * MeSH
• Child MeSH
• Humans MeSH
• Logistic Models MeSH
• Adolescent MeSH
• Odds Ratio MeSH
• Oral Hygiene statistics & numerical data   MeSH
• Oral Health * MeSH
• Prevalence MeSH
• Cross-Sectional Studies MeSH
• Schools MeSH
• Socioeconomic Factors MeSH
• Social Class MeSH
• Health Behavior * MeSH
• Self Report * MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Slovakia MeSH

OBJECTIVES: This study investigated the differences between non-excessive, moderately excessive, and highly excessive internet use among adolescents. These differences were explored in terms of personal characteristics, psychological difficulties, environmental factors, and manner of internet use. METHODS: A representative sample was investigated, consisting of 18,709 adolescents aged 11-16 and their parents, from 25 European countries. Excessive internet use was measured using a five item scale covering following factors: salience, conflict, tolerance, withdrawal symptoms, and relapse and reinstatement. The main data analysis utilised multinomial and binary logistic regression models. RESULTS: The vast majority of respondents reported no signs of excessive internet use. Moderately excessive users (4.4%) reported higher emotional and behavioural difficulties, but also more sophisticated digital skills and a broader range of online activities. The highly excessive users (1.4%) differed from the non-excessive and moderately excessive users in their preference for online games and in having more difficulties with self-control. CONCLUSIONS: Adolescents who struggle with attention and self-control and who are inclined toward online gaming may be especially vulnerable to the otherwise uncommon phenomenon of excessive internet use.

• MeSH
• Time Factors MeSH
• Adolescent Behavior psychology   MeSH
• Child MeSH
• Mental Health * MeSH
• Risk Assessment MeSH
• Internet utilization   MeSH
• Confidence Intervals MeSH
• Humans MeSH
• Logistic Models MeSH
• Adolescent MeSH
• Multivariate Analysis MeSH
• Behavior, Addictive * MeSH
• Odds Ratio MeSH
• Attention physiology   MeSH
• Cross-Sectional Studies MeSH
• Surveys and Questionnaires MeSH
• Self Concept MeSH
• Video Games statistics & numerical data   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Comparative Study MeSH
• Geographicals
• Europe MeSH

There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy. The purpose of this study was to examine neonatal outcomes concerning the use of OMT during pregnancy. We used nationwide registry linkages from the Czech Republic (2000-2014) and Norway (2004-2013). We compared prenatally OMT-exposed newborns with (a) newborns of women hospitalized with opioid use disorder during pregnancy in the Czech sample and (b) newborns with neonatal abstinence syndrome (NAS) in Norway. We performed multivariate linear and binary logistic regression exploring the associations between OMT and neonatal outcomes (growth parameters, gestational age, fetal death, small for gestational age, Apgar score, and NAS). Regression coefficients (b) and odds ratios (ORs) were estimated. The cohorts consisted of 333 Czech, and 235 Norwegian OMT-exposed newborns, and 106 and 294 newborns in the comparison groups, respectively. In both countries, the neonatal growth parameters were similar in the OMT and the comparison groups. In Norway, OMT exposure prolonged gestational age (adjusted b = 0.96 weeks, 95% confidence interval [CI] =0.39-1.53) while the odds of preterm birth and Apgar score at 5 minutes were lower than in the comparison group (adjusted OR = 0.35, 0.16-0.75 and aOR = 0.21, 0.06-0.78, respectively). Newborns of women in OMT had similar growth parameters as newborns of women with opioid use disorders who were not in OMT during pregnancy. Overall, our findings do not suggest that OMT results in worse neonatal outcomes.

• MeSH
• Buprenorphine therapeutic use   MeSH
• Adult MeSH
• Pregnancy Complications drug therapy   MeSH
• Humans MeSH
• Logistic Models MeSH
• Methadone therapeutic use   MeSH
• Young Adult MeSH
• Infant, Newborn MeSH
• Neonatal Abstinence Syndrome epidemiology   MeSH
• Opiate Substitution Treatment MeSH
• Opioid-Related Disorders drug therapy   MeSH
• Registries MeSH
• Pregnancy MeSH
• Child Development MeSH
• Prenatal Exposure Delayed Effects epidemiology   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Young Adult MeSH
• Infant, Newborn MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Observational Study MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH
• Norway MeSH