Infectious agents and pathogenesis
1st ed. xxiv, 428 s. : il.
- Keywords
- Onkologie, Transplantace, Viry,
- MeSH
- DNA, Neoplasm MeSH
- Tumor Virus Infections complications MeSH
- Cell Transformation, Neoplastic MeSH
- DNA Tumor Viruses pathogenicity MeSH
- Oncogenic Viruses MeSH
- Viral Vaccines MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- onkologie
The practical approach series ; 214
xv, 312 s. : il.
- MeSH
- DNA, Viral MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- biologie
- virologie
Current topics in microbiology and immunology, ISSN 0070-217X 144
XIV, 284 s. : il., tab., grafy ; 26 cm
viii, 324 s. : il., tab.
- MeSH
- DNA, Neoplasm MeSH
- DNA, Viral MeSH
- Cell Transformation, Neoplastic MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- virologie
- biochemie
DNA virus infections are often lifelong and can cause serious diseases in their hosts. Their recognition by the sensors of the innate immune system represents the front line of host defence. Understanding the molecular mechanisms of innate immunity responses is an important prerequisite for the design of effective antivirotics. This review focuses on the present state of knowledge surrounding the mechanisms of viral DNA genome sensing and the main induced pathways of innate immunity responses. The studies that have been performed to date indicate that herpesviruses, adenoviruses, and polyomaviruses are sensed by various DNA sensors. In non-immune cells, STING pathways have been shown to be activated by cGAS, IFI16, DDX41, or DNA-PK. The activation of TLR9 has mainly been described in pDCs and in other immune cells. Importantly, studies on herpesviruses have unveiled novel participants (BRCA1, H2B, or DNA-PK) in the IFI16 sensing pathway. Polyomavirus studies have revealed that, in addition to viral DNA, micronuclei are released into the cytosol due to genotoxic stress. Papillomaviruses, HBV, and HIV have been shown to evade DNA sensing by sophisticated intracellular trafficking, unique cell tropism, and viral or cellular protein actions that prevent or block DNA sensing. Further research is required to fully understand the interplay between viruses and DNA sensors.
- MeSH
- DNA, Viral metabolism MeSH
- Herpesviridae * genetics metabolism MeSH
- DNA Virus Infections * MeSH
- Humans MeSH
- Polyomavirus * genetics MeSH
- Immunity, Innate MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Molecular biology intelligence unit
[1st ed.] 218 s. : obr., tab., grafy ; 27 cm
