FEM analysis
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- MeSH
- analýza metodou konečných prvků * využití MeSH
- anatomické modely MeSH
- biomechanika MeSH
- kyčelní kloub * fyziologie patologie MeSH
- lidé MeSH
- mechanický stres * MeSH
- osteoartróza diagnóza patologie MeSH
- počítačové zpracování obrazu MeSH
- radiografie využití MeSH
- software MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- MeSH
- acetabulum anatomie a histologie fyziologie patologie MeSH
- analýza metodou konečných prvků * využití MeSH
- anatomické modely MeSH
- biomechanika MeSH
- kyčelní kloub * fyziologie patologie MeSH
- kyčelní protézy využití MeSH
- lidé MeSH
- mechanické jevy MeSH
- pánev anatomie a histologie fyziologie patologie MeSH
- počítačová simulace využití MeSH
- statistika jako téma MeSH
- teoretické modely * MeSH
- transplantáty transplantace MeSH
- Check Tag
- lidé MeSH
- MeSH
- analýza metodou konečných prvků * využití MeSH
- anatomické modely * MeSH
- femur anatomie a histologie MeSH
- kostra MeSH
- lebka * anatomie a histologie fyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody využití MeSH
- mandibula anatomie a histologie MeSH
- počítačová rentgenová tomografie využití MeSH
- statistika jako téma MeSH
- teoretické modely MeSH
- Check Tag
- lidé MeSH
Predkladaný článok obsahuje štatistickú analýzu vzťahu medzi cenou lieku a doplatkom pacienta za liek pomocou panelovej regresie. V článku sú analyzované mesačné ceny kategorizovaných liekov a doplatkov pacientov za obdobie 2012 – 2017. Pre najčastejšie predpisované lieky alebo pre najnákladnejšie lieky boli pomocou štatistických testov vybrané vhodné modely – model s fixnými efektmi (FEM, LSDV) alebo model s náhodnými efektmi (REM) na vyjadrenie vzťahu medzi cenou lieku a doplatkom.
Presented paper deals with implementation panel data analysis method used to statistically analyze the relationship between the price of the drugs and the patient's supplementary payments. The monthly prices of drugs and supplementary payments are analyzed for the period 2012–2017. Suitable models – Fixed Effects Model (FEM, LSDV) or Random Effects Model (REM) for the relationship between price and supplementary payments are selected through statistical tests for the most commonly prescribed drugs and also for the most costly drugs.
- MeSH
- léčivé přípravky ekonomika MeSH
- lidé MeSH
- náklady a analýza nákladů MeSH
- náklady na léky * statistika a číselné údaje MeSH
- statistika jako téma MeSH
- úhrada služeb Medicare USA MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Slovenská republika MeSH
Large mandibular continuity defects pose a significant challenge in oral maxillofacial surgery. One solution to this problem is to use computer-guided surgical planning and additive manufacturing technology to produce patient-specific reconstruction plates. However, when designing customized plates, it is important to assess potential biomechanical responses that may vary substantially depending on the size and geometry of the defect. The aim of this study was to assess the design of two customized plates using finite element method (FEM). These plates were designed for the reconstruction of the lower left mandibles of two ameloblastoma cases (patient 1/plate 1 and patient 2/plate 2) with large bone resections differing in both geometry and size. Simulations revealed maximum von Mises stresses of 63 MPa and 108 MPa in plates 1 and 2, and 65 MPa and 190 MPa in the fixation screws of patients 1 and 2. The equivalent strain induced in the bone at the screw-bone interface reached maximum values of 2739 micro-strain for patient 1 and 19,575 micro-strain for patient 2. The results demonstrate the influence of design on the stresses induced in the plate and screw bodies. Of particular note, however, are the differences in the induced strains. Unphysiologically high strains in bone adjacent to screws can cause micro-damage leading to bone resorption. This can adversely affect the anchoring capabilities of the screws. Thus, while custom plates offer optimal anatomical fit, attention should be paid to the expected physiological forces on the plates and the induced stresses and strains in the plate-screw-bone assembly.
- MeSH
- analýza metodou konečných prvků MeSH
- dospělí MeSH
- interní fixátory MeSH
- kostní destičky MeSH
- kostní šrouby * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mandibula anatomie a histologie chirurgie MeSH
- mechanický stres * MeSH
- počítačová rentgenová tomografie metody MeSH
- počítačová simulace MeSH
- počítačové zpracování obrazu metody MeSH
- software MeSH
- tlak MeSH
- zákroky plastické chirurgie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Experimental modal analysis (EMA) of ultrasonic waveguides is important for many applications including design of ultrasonic surgical tools. However, most of the known sensors and instruments for measuring parameters of ultrasonic vibrations are limited to the measurements on the face surface of the ultrasonic waveguide and therefore unable to determine the spatial distribution of the parameters along its length, which in turn makes it difficult to identify natural modes and shapes. The article describes EMA of ultrasonic surgical waveguides based on the effect of inverse magnetostriction. During vibration of an ultrasonic waveguide the inverse magnetostriction generates alternating magnetic field which can be detected by means of an induction coil. Spatial resolution of the measurements can be achieved by application of the sensors with flat (spiral) induction coils. The sensors used in the study have simple design and low cost making them affordable for wide circle of scientists and engineers. The results of experimental studies implemented on exemplary waveguide for ultrasonic angioplasty made of AISI 321 steel are presented and discussed. The article also discusses the methods for theoretical and experimental determination of the sensitivity of the sensors used in the study. Experimental data are validated by comparing them to the results of computer-aided modal analysis using the finite element method (FEM) and found to be in good agreement with the results of FEM modeling (relative deviation of the vibratory displacements amplitude is about 4.7 %). As it follows from the experimental data and their comparison to the results of FEM modeling, the effect of inverse magnetostriction can be efficiently used for EMA of ultrasonic waveguides.
- MeSH
- analýza metodou konečných prvků MeSH
- biosenzitivní techniky přístrojové vybavení MeSH
- časná diagnóza MeSH
- kardiografie impedanční * metody přístrojové vybavení MeSH
- lidé MeSH
- modely kardiovaskulární MeSH
- pleurální výpotek * diagnóza patofyziologie MeSH
- plicní edém * diagnóza patofyziologie MeSH
- počítačová simulace MeSH
- pulzatilní průtok MeSH
- srdeční selhání * diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
BACKGROUND: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN). In addition, on an exploratory basis, we investigated whether baseline BP variability predicted the BP changes after RDN. METHODS: We analyzed 24-h BP recordings obtained at baseline and 6 months after RDN in 167 treatment-resistant hypertension patients (40% women; age, 56.7 years; mean 24-h BP, 152/90 mmHg) recruited at 11 expert centers. BP variability was assessed by weighted SD [SD over time weighted for the time interval between consecutive readings (SDiw)], average real variability (ARV), coefficient of variation, and variability independent of the mean (VIM). RESULTS: Mean office and 24-h BP fell by 15.4/6.6 and 5.5/3.7 mmHg, respectively (P < 0.001). In multivariable-adjusted analyses, systolic/diastolic SDiw and VIM for 24-h SBP/DBP decreased by 1.18/0.63 mmHg (P ≤ 0.01) and 0.86/0.42 mmHg (P ≤ 0.05), respectively, whereas no significant changes in ARV or coefficient of variation occurred. Furthermore, baseline SDiw (P = 0.0006), ARV (P = 0.01), and VIM (P = 0.04) predicted the decrease in 24-h DBP but not 24-h SBP after RDN. CONCLUSION: RDN was associated with a decrease in BP variability independent of the BP level, suggesting that responders may derive benefits from the reduction in BP variability as well. Furthermore, baseline DBP variability estimates significantly correlated with mean DBP decrease after RDN. If confirmed in younger patients with less arterial damage, in the absence of the confounding effect of drugs and drug adherence, baseline BP variability may prove a good predictor of BP response to RDN.
- MeSH
- hypertenze chirurgie MeSH
- krevní tlak * MeSH
- ledviny inervace chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření krevního tlaku MeSH
- sympatektomie * MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
