Q15488818 Dotaz Zobrazit nápovědu
- MeSH
- diabetes mellitus 2. typu dějiny MeSH
- hyperglykemie MeSH
- hypertenze komplikace MeSH
- hypertriglyceridemie komplikace MeSH
- inzulinová rezistence fyziologie MeSH
- kardiovaskulární nemoci MeSH
- komorbidita MeSH
- lidé MeSH
- metabolický syndrom diagnóza klasifikace patofyziologie MeSH
- obezita diagnóza komplikace MeSH
- Check Tag
- lidé MeSH
Eighteen nondiabetic volunteers were selected for these studies on the basis of their plasma magnesium (Mg) concentrations defined as being either high (> 0.83 mmol/L) or low (< 0.80 mmol/L). Although different in Mg concentration (0.90 +/- 0.02 vs. 0.73 +/- 0.01 mmol/L), the 2 groups were comparable in terms of age, gender distribution, body mass index, and waist to hip girth. Measurements were made of their plasma glucose and insulin concentrations in response to a 75-g oral glucose load and the steady state plasma insulin and glucose (SSPG) concentrations at the end of an 180-min infusion of octreotide, insulin, and glucose. The low Mg group had significantly higher plasma glucose (P < 0.001) and insulin (P < 0.002) concentrations after the oral glucose challenge. Although the steady state plasma insulin concentrations were similar during the infusion study, the SSPG concentration was significantly (P < 0.001) greater in the low Mg group (11.9 +/- 0.9 vs. 6.6 +/- 0.9 mmol/L). Finally, when the 18 patients were analyzed together, there were significant (P < 0.05 to P < 0.01) inverse correlations between Mg concentrations and glucose (r = -0.68) and insulin (r = -0.51) areas and SSPG concentrations (r = -0.60). Thus, a low Mg concentration in nondiabetic subjects was associated with relative insulin resistance, glucose intolerance, and hyperinsulinemia.
- MeSH
- dospělí MeSH
- genetická variace * MeSH
- glukózový toleranční test MeSH
- hořčík * krev MeSH
- inzulin krev MeSH
- inzulinová rezistence * MeSH
- krevní glukóza * metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
Contemporary endocrinology
1st ed. 10,374 s.
- MeSH
- inzulinová rezistence MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- vnitřní lékařství
Diabetes/metabolism reviews, ISSN 0742-4221 Supplement Vol. 9. 1
S79 s. : tab., grafy ; 28 cm
- MeSH
- diabetes mellitus MeSH
- fenfluramin farmakologie analogy a deriváty MeSH
- inzulinová rezistence MeSH
- Publikační typ
- kongresy MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- vnitřní lékařství
Hormone and metabolic research ; Supplement Vol. 24. 27
IX, 62 s. : obr., tab., grafy ; 27 cm
Frontiers in diabetes ; Vol. 10
192 s. : obr., tab., přeruš.bibliogr.
