The mixed dissociation constants of five drug acids-ambroxol, antazoline, naphazoline, oxymetazoline and ranitidine-at various ionic strengths I of range 0.01 and 1.0 and at temperatures of 25 and 37 degrees C were determined using SQUAD(84) regression analysis of the pH-spectrophotometric titration data. A proposed strategy of efficient experimentation in a protonation constants determination, followed by a computational strategy for the chemical model with a protonation constants determination, is presented on the protonation equilibria of ambroxol. The thermodynamic dissociation constant pK(a)(T) was estimated by non-linear regression of {pK(a), I} data at 25 and 37 degrees C: for ambroxol p K (a ,1)(T )=8.05 (6) and 8.25 (4), logbeta (21)(T )=11.67 (6) and 11.83 (8), for antazoline p K (a ,1)(T )=7.79 (2) and 7.83 (6), p K (a ,2)(T )=9.74 (3) and 9.55 (2), for naphazoline pK (a ,1)(T )=10.81 (1) and 10.63 (1), for oxymethazoline pK (a ,1)(T )=10.62 (2) and 10.77 (7), pK(a,2)(T)=12.03(3) and 11.82 (4) and for ranitidine p K (a ,1)(T )=1.89 (1) and 1.77 (1). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.
- Keywords
- HYPO-TEARS, TEARS NATURALE FREE, ISOPTO TEARS, LACRISYN, HYPO TEARS GEL, LACRYVISC, OPHTHALMO-SEPTONEX, VISINE, SPERSALLERG, EVERCIL, LIVOSTIN, EMADINE, ALOMIDE, OPTICROMNAAXIA,
- MeSH
- Humans MeSH
- Eye Diseases diagnosis etiology therapy MeSH
- Check Tag
- Humans MeSH
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- MeSH
- Rhinitis, Allergic diagnosis drug therapy MeSH
- Hypersensitivity * MeSH
- Histamine H3 Antagonists administration & dosage MeSH
- Histamine H1 Antagonists MeSH
- Histamine H2 Antagonists administration & dosage MeSH
- Antazoline administration & dosage MeSH
- Beclomethasone administration & dosage adverse effects MeSH
- Dimethindene administration & dosage MeSH
- Phenylephrine administration & dosage therapeutic use MeSH
- Adrenal Cortex Hormones adverse effects therapeutic use MeSH
- Imidazoles administration & dosage therapeutic use MeSH
- Nonprescription Drugs * MeSH
- Nasal Sprays MeSH
- Sympathomimetics therapeutic use MeSH
- Keywords
- OPTICROM, CROMOLYN, PROMESULF, SANORIN, ANALERGIN, SPERSALLERG, NAAXIA, LIVOSTIN, ALOMIDE, PATANOL, ZADITEN, NACLOF, VISINE, OCULOTECT,
- MeSH
- Hypersensitivity drug therapy prevention & control MeSH
- Anti-Allergic Agents therapeutic use MeSH
- Humans MeSH
- Eye MeSH
- Check Tag
- Humans MeSH
- Keywords
- OPTICROM, INTAL, ZADITEN, HISTAMAL, TAVEGYL, KENALOG, SOLCOSERYL EYE-GEL, SPERSALLERG,
- MeSH
- Conjunctivitis, Allergic drug therapy MeSH
- Desensitization, Immunologic MeSH
- Child MeSH
- Keratoconjunctivitis drug therapy MeSH
- Humans MeSH
- Seasons MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Geographicals
- Qatar MeSH
