- MeSH
- Blood Pressure Monitoring, Ambulatory methods utilization MeSH
- Stroke complications mortality prevention & control MeSH
- Databases, Factual utilization MeSH
- Financing, Organized MeSH
- Myocardial Infarction complications mortality prevention & control MeSH
- Cardiovascular Diseases etiology mortality prevention & control MeSH
- Humans MeSH
- Masked Hypertension diagnosis MeSH
- Evidence-Based Medicine methods trends MeSH
- MEDLINE utilization MeSH
- Blood Pressure Determination methods trends utilization MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Statistics as Topic MeSH
- White Coat Hypertension diagnosis complications MeSH
- Check Tag
- Humans MeSH
- Publication type
- Meta-Analysis MeSH
- Review MeSH
Ezetimib je nové hypolipidemikum, které v tenkém střevě inhibuje absorpci cholesterolu pocházejícího z potravy. Podstatně snižuje koncentraci LDL cholesterolu (low-density lipoprotein cholesterol) v monoterapii, i v kombinaci se statiny. Nicméně jeho vliv na kardiovaskulární mortalitu zůstává nejasný. Zhodnotili jsme relevantní publikovaná data zabývající se působením ezetimibu na různé fáze aterosklerotického procesu. K nalezení relevantních abstrakt a článků v anglickém jazyce srovnávajících terapii ezetimibem a statiny za účelem ovlivnění aterosklerotického procesu jsme použili databáze MEDLINE, EMBASE, BIOSIS a jiné. Na základě dostupných dat se zdá, že ezetimib vede k redukci zánětu, pokud je podáván v kombinaci se statiny, ale jeho vliv na funkci endotelu je nejasný. Účinek na progresi ischemické choroby srdeční nebo prevenci kardiovaskulárních příhod není dosud znám. Dle dostupných dat je užití ezetimibu jako léku druhé či třetí volby vhodné k dosažení cílových hodnot LDL cholesterolu.
- MeSH
- Carotid Arteries metabolism physiopathology drug effects MeSH
- Atherosclerosis drug therapy therapy MeSH
- Azetidines administration & dosage metabolism therapeutic use MeSH
- Biomarkers blood metabolism MeSH
- Diagnostic Techniques, Cardiovascular utilization MeSH
- Drug Therapy, Combination MeSH
- Cholesterol, LDL metabolism adverse effects drug effects MeSH
- Humans MeSH
- Evidence-Based Medicine trends MeSH
- MEDLINE utilization MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Risk Factors MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors metabolism therapeutic use MeSH
- Inflammation blood metabolism MeSH
- Check Tag
- Humans MeSH
- MeSH
- Cisapride adverse effects therapeutic use MeSH
- Diuretics administration & dosage adverse effects MeSH
- Electrocardiography drug effects MeSH
- Angiotensin-Converting Enzyme Inhibitors administration & dosage adverse effects MeSH
- Herb-Drug Interactions MeSH
- Food-Drug Interactions physiology immunology MeSH
- Congresses as Topic MeSH
- Prescriptions classification standards MeSH
- Drug Interactions * MeSH
- Humans MeSH
- Medication Errors MeSH
- MEDLINE utilization MeSH
- Meta-Analysis as Topic * MeSH
- Metabolic Side Effects of Drugs and Substances administration & dosage metabolism adverse effects MeSH
- Drug-Related Side Effects and Adverse Reactions * diagnosis prevention & control MeSH
- Fruit and Vegetable Juices classification adverse effects utilization MeSH
- Statistics as Topic MeSH
- Hypericum classification adverse effects drug effects MeSH
- Water-Electrolyte Balance drug effects MeSH
- Check Tag
- Humans MeSH
- MeSH
- Antioxidants pharmacology classification therapeutic use MeSH
- Cardiovascular Diseases * drug therapy MeSH
- Carotenoids therapeutic use MeSH
- Humans MeSH
- Lipoproteins metabolism drug effects MeSH
- MEDLINE * utilization MeSH
- Meta-Analysis as Topic MeSH
- Statistics as Topic MeSH
- Tocopherols therapeutic use MeSH
- Vitamin A therapeutic use MeSH
- Vitamin D therapeutic use MeSH
- Vitamin E therapeutic use MeSH
- Vitamin K therapeutic use MeSH
- Vitamins * pharmacology classification therapeutic use MeSH
- Check Tag
- Humans MeSH
