Acta oto-laryngologica ; Supplement. 491
184 s. : grafy, obr., tab. ; 24 cm
- MeSH
- Congresses as Topic MeSH
- Hearing Disorders MeSH
- Auditory Cortex physiopathology physiology MeSH
- Publication type
- Collected Work MeSH
- Geographicals
- Portugal MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- otorinolaryngologie
- neurovědy
- MeSH
- Behavior MeSH
- Evoked Potentials MeSH
- Cats MeSH
- Cerebral Cortex physiology MeSH
- Check Tag
- Cats MeSH
Acta oto-laryngologica, ISSN 0365-5237 Supplement Vol. 117. 532
144 s. : il. ; 30 cm
- MeSH
- Auditory Cortex physiology MeSH
- Publication type
- Congress MeSH
- Conspectus
- Lékařské vědy. Lékařství
- NML Fields
- otorinolaryngologie
- fyziologie
- MeSH
- Afferent Pathways physiology MeSH
- Cats MeSH
- Cerebral Cortex physiology MeSH
- Brain Stem physiology MeSH
- Check Tag
- Cats MeSH
Journal of laryngology & otology, ISSN 0022-2151 vol. 114, suppl. 27, December 2000
55 s. : il., tab., grafy ; 30 cm
- MeSH
- Audiometry MeSH
- Auditory Diseases, Central MeSH
- Prosthesis Implantation MeSH
- Cochlear Implants MeSH
- Brain Stem MeSH
- Neurofibromatoses MeSH
- Auditory Cortex MeSH
- Publication type
- Congress MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- otorinolaryngologie
- otorinolaryngologie
Age-related hearing loss (presbycusis) is caused mainly by the hypofunction of the inner ear, but recent findings point also toward a central component of presbycusis. We used MR morphometry and diffusion tensor imaging (DTI) with a 3T MR system with the aim to study the state of the central auditory system in a group of elderly subjects (>65years) with mild presbycusis, in a group of elderly subjects with expressed presbycusis and in young controls. Cortical reconstruction, volumetric segmentation and auditory pathway tractography were performed. Three parameters were evaluated by morphometry: the volume of the gray matter, the surface area of the gyrus and the thickness of the cortex. In all experimental groups the surface area and gray matter volume were larger on the left side in Heschl's gyrus and planum temporale and slightly larger in the gyrus frontalis superior, whereas they were larger on the right side in the primary visual cortex. Almost all of the measured parameters were significantly smaller in the elderly subjects in Heschl's gyrus, planum temporale and gyrus frontalis superior. Aging did not change the side asymmetry (laterality) of the gyri. In the central part of the auditory pathway above the inferior colliculus, a trend toward an effect of aging was present in the axial vector of the diffusion (L1) variable of DTI, with increased values observed in elderly subjects. A trend toward a decrease of L1 on the left side, which was more pronounced in the elderly groups, was observed. The effect of hearing loss was present in subjects with expressed presbycusis as a trend toward an increase of the radial vectors (L2L3) in the white matter under Heschl's gyrus. These results suggest that in addition to peripheral changes, changes in the central part of the auditory system in elderly subjects are also present; however, the extent of hearing loss does not play a significant role in the central changes.
- MeSH
- Auditory Diseases, Central pathology MeSH
- Adult MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Young Adult MeSH
- Nerve Fibers, Myelinated pathology MeSH
- Presbycusis pathology physiopathology MeSH
- Aged MeSH
- Auditory Pathways pathology MeSH
- Auditory Cortex pathology MeSH
- Aging pathology physiology MeSH
- Diffusion Tensor Imaging MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
