harmonization of processes
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Use of a multi-sensor approach can provide citizens with holistic insights into the air quality of their immediate surroundings and their personal exposure to urban stressors. Our work, as part of the ICARUS H2020 project, which included over 600 participants from seven European cities, discusses the data fusion and harmonization of a diverse set of multi-sensor data streams to provide a comprehensive and understandable report for participants. Harmonizing the data streams identified issues with the sensor devices and protocols, such as non-uniform timestamps, data gaps, difficult data retrieval from commercial devices, and coarse activity data logging. Our process of data fusion and harmonization allowed us to automate visualizations and reports, and consequently provide each participant with a detailed individualized report. Results showed that a key solution was to streamline the code and speed up the process, which necessitated certain compromises in visualizing the data. A thought-out process of data fusion and harmonization of a diverse set of multi-sensor data streams considerably improved the quality and quantity of distilled data that a research participant received. Though automation considerably accelerated the production of the reports, manual and structured double checks are strongly recommended.
- MeSH
- lidé MeSH
- ukládání a vyhledávání informací MeSH
- velkoměsta MeSH
- znečištění ovzduší * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- velkoměsta MeSH
Investigating cerebral metabolism in vivo at a microscopic level is essential for understanding brain function and its pathological alterations. The intricate signaling and metabolic dynamics between neurons, glia, and microvasculature requires much more detailed understanding to better comprehend the mechanisms governing brain function and its disease-related changes. We recently demonstrated that pharmacologically-induced alterations to different steps of cerebral metabolism can be distinguished utilizing 2-photon fluorescence lifetime imaging of endogenous reduced nicotinamide adenine dinucleotide (NADH) fluorescence in vivo. Here, we evaluate the ability of the phasor analysis method to identify these pharmacological metabolic alterations and compare the method's performance with more conventional nonlinear curve-fitting analysis. Visualization of phasor data, both at the fundamental laser repetition frequency and its second harmonic, enables resolution of pharmacologically-induced alterations to mitochondrial metabolic processes from baseline cerebral metabolism. Compared to our previous classification models based on nonlinear curve-fitting, phasor-based models required fewer parameters and yielded comparable or improved classification accuracy. Fluorescence lifetime imaging of NADH and phasor analysis shows utility for detecting metabolic alterations and will lead to a deeper understanding of cerebral energetics and its pathological changes.
- MeSH
- bikukulin analogy a deriváty farmakologie MeSH
- biologické markery metabolismus MeSH
- biologické modely MeSH
- hlodavci fyziologie MeSH
- intravitální mikroskopie metody MeSH
- lidé MeSH
- mikroskopie fluorescenční multifotonová metody MeSH
- mitochondrie účinky léků metabolismus MeSH
- modely nemocí na zvířatech MeSH
- mozková kůra účinky léků metabolismus MeSH
- NAD metabolismus MeSH
- nelineární dynamika MeSH
- potkani Sprague-Dawley MeSH
- záchvaty chemicky indukované diagnostické zobrazování metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- srovnávací studie MeSH
... OF CONTENTS -- FOREWORD 1 -- LIST OF MEMBERS OF THE EXPOSURE MODELLING SUBCOMMITTEE OF THE IPCS HARMONIZATION ... ... 3.2.2 Dermal exposure models 41 -- 3.2.3 Ingestion models 44 -- 3.2.4 Multimedia models 48 iii -- Harmonization ... ... CHARACTERIZING EXPOSURE MODELS 54 -- 4.1 General model description 54 -- 4.2 Model inputs 55 -- 4.3 Model processes ...
IPCS harmonization project document ; no. 3
iv, 70 s. : tab. ; 30 cm
- MeSH
- anorganické látky škodlivé účinky farmakokinetika MeSH
- biologické modely MeSH
- dávka bez pozorovaného nepříznivého účinku MeSH
- farmakologické a toxikologické jevy MeSH
- hodnocení rizik normy MeSH
- organické látky farmakokinetika toxicita MeSH
- Konspekt
- Chemie. Mineralogické vědy
- NLK Obory
- chemie, klinická chemie
- environmentální vědy
- NLK Publikační typ
- publikace WHO
Vývoj širokopásmových ultrazvukových měničů a nová, zcela digitalizovaná technologie zpracování obrazu vedly k zavedení tzv. harmonického zobrazení. Při něm sonda nepřijímá odrazy základniho vysílaného kmitočtu, nýbrž kmity 2. harmonického kmitočtu. Ty vznikají jednak kmitáním bublin kontrastních látek vpravených do krevního oběhu (kontrastní harmonické zobrazení), jednak kmitáním samotných tkáňových struktur v důsledku nelineárního šíření ultrazvuku v tkáních (přirozené harmonické zobrazení). Potlačením základního kmitočtu dojde v oblasti 2. harmonického kmitočtu k výraznému zlepšení poměru signál/šum a tím ke zvýšení kontrastu a prostorového rozlišení. Harmonické zobrazení je zvláště výhodné u pacientů, které je možno konvenčním způsobem ultrazvukového zobrazení jen obtížně vyšetřit.
Development of new broad-band ultrasound transducers as well as new, fully digitised, technology of image processing opened the way to harmonic imaging. In this new technology the transducer does not receive echoes of the basic emitted frequency, but it receives vibrations of the 2nd harmonic frequency which originates either from vibration of bubbles of echocontrast agents, introduced in the circulatory system (contrast harmonic imaging), or from vibration of tissue structures as a consequence of non-linear wave propagation in tissues (native harmonic imaging). By suppressing the basic frequency a significant improvement of the sigpial/noise ratio in the range of 2nd harmonic frequency takes place. This is followed by improvement of contrast and spatial resolution. Harmonic imaging is especially useful in patients where conventional ultrasound examination is difficult.
... default subfactors for toxicokinetic and toxicodynamic aspects 16 -- 2.3 Separation of the overall process ... ... chemical moiety 43 -- 3.4.2 Consideration of end-point 45 -- 3.4.3 Experimental data 45 iii -- Harmonization ...
IPCS harmonization project document ; no. 2
iv, 96 s. : tab., grafy ; 30 cm
- MeSH
- chemie MeSH
- dávka bez pozorovaného nepříznivého účinku MeSH
- farmakokinetika MeSH
- genetická variace MeSH
- hodnocení rizik normy MeSH
- specializované použití chemických látek MeSH
- testy toxicity MeSH
- Publikační typ
- směrnice MeSH
- Konspekt
- Chemie. Mineralogické vědy
- NLK Obory
- chemie, klinická chemie
- NLK Publikační typ
- publikace WHO
... Та leb -- 117Table of Contents g- ECSBM -- Harmonic Dynamics of a-L-Fucose in the Crystalline State ... ... Sekkal-Rahal -- Physico-Chemical Properties of Chemotherapeutics and Agents -- Relaxation Processes and ... ... Danikiewicz -- Photoinduced Processes in Biomolecules -- Searching for the Chemical Equivalent of Nitrogenase ... ... G. plvovarenko -- Axial Ligand Binding and Release Processes in Nickel(II)-Tetraphenylporphyrin -- Revisited ...
2 sv. (150 s., s. 151-274) : il., tab. ; 25 cm
BACKGROUND: Multifunctional two-photon laser scanning microscopy provides attractive advantages over conventional two-photon laser scanning microscopy. For the first time, simultaneous measurement of the second harmonic generation (SHG) signals in the forward and backward directions and two photon excitation fluorescence were achieved from the deep shade plant Selaginella erythropus. RESULTS: These measurements show that the S. erythropus leaves produce high SHG signals in both directions and the SHG signals strongly depend on the laser's status of polarization and the orientation of the dipole moment in the molecules that interact with the laser light. The novelty of this work is (1) uncovering the unusual structure of S. erythropus leaves, including diverse chloroplasts, various cell types and micromophology, which are consistent with observations from general electron microscopy; and (2) using the multifunctional two-photon laser scanning microscopy by combining three platforms of laser scanning microscopy, fluorescence microscopy, harmonic generation microscopy and polarizing microscopy for detecting the SHG signals in the forward and backward directions, as well as two photon excitation fluorescence. CONCLUSIONS: With the multifunctional two-photon laser scanning microscopy, one can use noninvasive SHG imaging to reveal the true architecture of the sample, without photodamage or photobleaching, by utilizing the fact that the SHG is known to leave no energy deposition on the interacting matter because of the SHG virtual energy conservation characteristic.
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- chloroplasty chemie ultrastruktura MeSH
- konfokální mikroskopie metody MeSH
- listy rostlin chemie ultrastruktura MeSH
- mikroskopie fluorescenční multifotonová metody MeSH
- počítačové zpracování obrazu metody MeSH
- Selaginellaceae chemie ultrastruktura MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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- algoritmy MeSH
- financování organizované MeSH
- ledviny ultrasonografie MeSH
- lidé MeSH
- pankreas ultrasonografie MeSH
- počítačové zpracování obrazu metody přístrojové vybavení MeSH
- srdce MeSH
- ultrasonografie metody přístrojové vybavení trendy MeSH
- vylepšení obrazu metody přístrojové vybavení MeSH
- Check Tag
- lidé MeSH
OBJECTIVES: It has been suggested that Tourette syndrome (TS) might be associated with alterations of the attention system, but the nature of these alterations and the underlying neuroanatomical network remains elusive. We aimed at investigating the functional neuroanatomical modulators of attention allocation towards predictable versus unpredictable stimuli in boys with TS. METHODS: Using functional magnetic resonance imaging, we ran a harmonic expectancy violation paradigm in 17 boys with TS and 23 matched healthy controls (HCs). We presented chord sequence in which the first four chords induced a strong expectancy for a harmonic chord at the next position. In 70% this expectancy was fulfilled (harmonic), in 30% the expectancy was violated (disharmonic). RESULTS: HCs responded faster to the disharmonic compared to harmonic chords, indicating a stronger attention allocation towards unpredictable stimuli, while this effect was not found in boys with TS. HCs showed stronger anterior cingulate cortex (ACC) activation during disharmonic compared to harmonic chords. Boys with TS showed stronger ACC activation during harmonic chords, which was associated with greater tic severity. CONCLUSIONS: Our findings indicate that boys with TS showed altered reactions towards predictable versus unpredictable stimuli in brain regions playing an important role in attention control. This might indicate altered allocation of attention towards those stimuli.
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- cingulární gyrus diagnostické zobrazování fyziologie patofyziologie MeSH
- dítě MeSH
- exekutivní funkce fyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mapování mozku metody MeSH
- mladiství MeSH
- pozornost fyziologie MeSH
- psychomotorický výkon fyziologie MeSH
- sluchová percepce fyziologie MeSH
- Tourettův syndrom diagnostické zobrazování patofyziologie MeSH
- vnímání času fyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
