hematologic parameters
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Changes of selected hematologic parameters were studied in six patients treated with immunoadsorption for myasthenia gravis. The mean duration of therapy was 18.6months; 245 procedures were performed in total. Before and after each procedure the full blood count was examined. A decrease was noted in the hemoglobin concentration (median -7.27%) and in platelet count (median -5.63%) after each procedure. On the other hand, an increase in leukocyte count was noticed after each procedure (median 6.63%). However, in three patients, it was observed that with increasing numbers of procedures, the leukocyte count rises were lower during long-term treatment. We suppose that the decrease in hemoglobin concentration was induced both by the large volume of blood samples collected for laboratory testing and by the residual volume of blood which remains in the tubing. From the continuous decrease in leukocyte count after long-term treatment with immunoadsorption in our three patients, it may be concluded, that some type of immunomodulatory effect (immunosuppression) is involved.
- MeSH
- časové faktory MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- myasthenia gravis komplikace krev terapie MeSH
- počet leukocytů MeSH
- senioři MeSH
- separace krevních složek škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
ix, 314 s. : il., tab. ; 26 cm
- MeSH
- hematologické nádory diagnóza MeSH
- leukemie diagnóza MeSH
- lymfom diagnóza MeSH
- nádorové biomarkery MeSH
- prognóza MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- hematologie a transfuzní lékařství
- onkologie
Kritická končatinová ischémia (CLI - critical limb ischaemia) predstavuje závažný medicínsky a socioekonomický problém. Incidencia z roka na rok stúpa a v súčasnosti pripadá na 1 milión obyvateľov 500-1000 pacientov s CLI. Na Klinike cievnej chirurgie SÚSCH sme v rokoch 2000-2004 uskutočnili klinickú štúdiu, ktorej cieľom bolo sledovanie vybraných biochemických a hematologických parametrov počas reperfúzie u pacientov s CLI. Predmetom nášho záujmu boli možnosti medikamentózneho ovplyvnenia elastázy polymorfonukleárnych leukocytov (PMNL) a neutrofil-lymfocytárneho indexu, ktorý je považovaný za spoľahlivý indikátor závažnosti klinického stavu.
CLI represents a major medical and social problem. The incidence is increasing and currently it was estimated 500-1000 per 1 million inhabitants. We carried out a clinical study (2000-2004) concerning monitoring of some hematological and biochemical markers during reperfusion in patients with CLI. The subject of our interest included possibilities to influence PMNL elastase by medical means and neutrophil-lymphocyte ratio which is considered a reliable and simple parameter to assess severity of clinical conditions.
- MeSH
- biochemická analýza krve statistika a číselné údaje MeSH
- chlorochin farmakologie MeSH
- finanční podpora výzkumu jako téma MeSH
- hematologické testy statistika a číselné údaje MeSH
- ischemie chirurgie krev MeSH
- leukocytární elastasa účinky léků MeSH
- lidé MeSH
- reperfuze metody MeSH
- reperfuzní poškození farmakoterapie imunologie MeSH
- Check Tag
- lidé MeSH
- MeSH
- anemie farmakoterapie MeSH
- biomedicínský výzkum MeSH
- králíci MeSH
- levamisol MeSH
- revmatoidní artritida komplikace MeSH
- Check Tag
- králíci MeSH
- Publikační typ
- srovnávací studie MeSH
Na morčatech byly ve dvou časových intervalech (3 a 24 hodin po expozici) studovány účinky akutní expozice oxidu siřičitému (400ppm, 3 hod) na vybrané biochemické, hematologické a histologické parametry. Exponované skupiny byly porovnány s kontrolními, které byly vystaveny za stejných podmínek vzduchu. V intervalu 3 hodiny od ukončení expozice nebyly nalezeny změny hladin sledovaných iontů, s výjimkou signifikantně nižší hladiny kalia u exponovaných zvířat (rozdíl oproti kontrolám činil 54.7 %). Po 24 hodinách byly kromě snížené hladiny kalia v porovnání s kontrolní skupinou (rozdíl 67,1 %) nižší i hladiny kalcia (88,8 %) a magnesia (82,3 %). Změny hematologických parametrů byly nejednotné a nevykazovaly žádnou jednoznačnou tendenci. Histologický obraz myokardu byl u všech zvířat normální. Závěr: akutní expozice oxidu siřičitému nevyvolala u většiny sledovaných parametrů signifikantní změny.
The effects of acute exposure to SO2(400ppm, 3 hrs) on biochemical, haematological and histological parameters were studied in guinea pigs in two time intervals (3hrs and 24hrs after the exposure). The exposed groups were compares with sham exposed ones. Mostly no significant changes of ion concentrations between the of significantly ůower blood potassium level (the difference was 54.7%). After 24 hours lower levels of potassium (67.1%) calcium (88.8%) and magnesium (82.3%) were found in comparison with the control group. The changes of haematological parameters did not show any consistent trends, the histological picture of myocardium was normal. The acute exposure of guinea pigs did not induce consistent and significant changes in most of the followed biochemical, haematological and histological parameters.
Acta medica Scandinavica, ISSN 0001-3101 suppl. 522
40 s. : tab. ; 24 cm
The objective of this research was to determine the effect of L-carnitine antioxidant ability on some hematological parameters such as the extent of red blood corpuscles (RBCs), "Packed cells volume (PCV)", Hemoglobin (Hb), and Mean cellular volume (MCV) in normal and oxidative stress exposed rats respectively. Using an animal model, "Hydrogen peroxide ((H2O2 0.5 %)" was mixed with drinking tap water to induce oxidative stress through the experiment period (30 days). Three groups were used in this study (each containing 7 rats) one of them was the negative control group and the other two were the positive control group (oxidative stress group treated with H2O2) and the treatment group treated with H2O2 + L-carnitine. The oxidative stress group showed a significant decrease (P<0.05) in RBCs count, and no significant differences (P<0.05) were observed in Hb, PCV, and MCV compared with the control group on the other hand the treatment group revealed a significant increase (P<0.05) in RBCs count in cooperation with the oxidative stress group. It can be concluded that L-carnitine has a positive key role toward H2O2 induced oxidative stress. This role positively affects the red bone marrow and erythropoiesis through balancing the negative effect of oxidative stress and can be monitored through RBCs count only.
- MeSH
- erytrocyty MeSH
- erytropoéza fyziologie MeSH
- hematologické testy MeSH
- hemoglobiny MeSH
- karnitin * fyziologie krev terapeutické užití MeSH
- modely nemocí na zvířatech * MeSH
- oxidační stres fyziologie MeSH
- peroxid vodíku škodlivé účinky MeSH
- počet buněk MeSH
- výzkum MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
Hematologic malignancies (HM) comprise diverse cancers of lymphoid and myeloid origin, including lymphomas (approx. 40%), chronic lymphocytic leukemia (CLL, approx. 15%), multiple myeloma (MM, approx. 15%), acute myeloid leukemia (AML, approx. 10%), and many other diseases. Despite considerable improvement in treatment options and survival parameters in the new millennium, many patients with HM still develop chemotherapy‑refractory diseases and require re-treatment. Because frontline therapies for the majority of HM (except for CLL) are still largely based on classical cytostatics, the relapses are often associated with defects in DNA damage response (DDR) pathways and anti-apoptotic blocks exemplified, respectively, by mutations or deletion of the TP53 tumor suppressor, and overexpression of anti-apoptotic proteins of the B-cell lymphoma 2 (BCL2) family. BCL2 homology 3 (BH3) mimetics represent a novel class of pro-apoptotic anti-cancer agents with a unique mode of action-direct targeting of mitochondria independently of TP53 gene aberrations. Consequently, BH3 mimetics can effectively eliminate even non-dividing malignant cells with adverse molecular cytogenetic alterations. Venetoclax, the nanomolar inhibitor of BCL2 anti-apoptotic protein has been approved for the therapy of CLL and AML. Numerous venetoclax-based combinatorial treatment regimens, next-generation BCL2 inhibitors, and myeloid cell leukemia 1 (MCL1) protein inhibitors, which are another class of BH3 mimetics with promising preclinical results, are currently being tested in several clinical trials in patients with diverse HM. These pivotal trials will soon answer critical questions and concerns about these innovative agents regarding not only their anti-tumor efficacy but also potential side effects, recommended dosages, and the optimal length of therapy as well as identification of reliable biomarkers of sensitivity or resistance. Effective harnessing of the full therapeutic potential of BH3 mimetics is a critical mission as it may directly translate into better management of the aggressive forms of HM and could lead to significantly improved survival parameters and quality of life in patients with urgent medical needs.
- MeSH
- apoptóza fyziologie MeSH
- bicyklické sloučeniny heterocyklické terapeutické užití MeSH
- biologické markery metabolismus MeSH
- hematologické nádory farmakoterapie metabolismus MeSH
- lidé MeSH
- nádorový supresorový protein p53 metabolismus MeSH
- poškození DNA účinky léků genetika MeSH
- sulfonamidy terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The aim of this research was determined the effect of respiratory intervention for twelve weeks and physical intervention for twelve weeks on selected parameters of heart rate variability in hematooncological patients after treatment. Spectral analysis of heart rate variability was measured by DiANS PF8 machine with Medical DiANS PC software. Evaluated were complex indices – Total score and Sympathovagal balance (S-V balance). The intervention programme was composed of three months of respiratory training and then three months of physical training. The experimental group, which absolved this combination of respiratory and physical intervention, was assessed at free time points: firstly, before the respiratory intervention, secondly between the respiratory and the physical intervention and thirdly after the physical intervention. The control group (without intervention) was measured twice between six months. 30 hematooncological patients (16 women and 14 men) were participated in this research, ranging in age 53,74±14,76 years from Internal Hematology and Oncology Clinic of The University Hospital Brno. Results of selected parameters of heart rate variability showed improvements, but without statistically significant effect of intervention programme.
